CAJ | 학술논문

目的探讨脂蛋白相关磷脂酶A2(Lp-PLA2)活性水平的性别差异及其与心血管病危险因素的关系.方法以参加“中国多省市心血管病危险因素队列研究”2002年危险因素调查的1541例北京地区45 ～ 74岁队列人群中资料完整的1471人(男性688人,女性783人)作为研究对象.Lp-PLA2活性水平采用比色法进行检测.对男女两性的Lp-PLA2活性水平以及Lp-PLA2活性与危险因素的关系进行了分析.结果 (1)男女两性Lp-PLA2活性水平分别为(22.73±8.52) nmol·min-1 ·ml-1和(20.01±8.06) nmol·min-1·ml-(P＜0.01).(2)男性的年龄、腰围、收缩压、舒张压以及高血压患病率高于女性,女性的总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)高于男性(P＜0.05或P＜0.01).(3)Pearson相关分析显示,男性Lp-PLA2活性水平与肥胖指标(腰围和体质指数)、血压(收缩压和舒张压)、血脂(TC、LDL-C、HDL-C和甘油三酯)均相关(P均＜0.01);女性Lp-PLA2活性水平与年龄和血脂相关(P＜0.05或P＜0.01),而与肥胖指标和血压的相关性低于男性(女性r值0.02～0.08;男性r值0.10～0.16).多因素logistic回归分析调整年龄、腰围、收缩压、空腹血糖、LDL-C、HDL-C、甘油三酯和高敏C反应蛋白后,男性Lp-PLA2活性水平仍高于女性(OR=1.72,95％CI:1.34 ～2.21,P＜0.01).结论男性的Lp-PLA2活性水平高于女性,且与主要心血管病危险因素的关系较强,但此性别差异并不能够完全由主要危险因素解释.
목적 탐토지단백상관린지매A2(Lp-PLA2)활성수평적성별차이급기여심혈관병위험인소적관계.방법 이삼가“중국다성시심혈관병위험인소대렬연구”2002년위험인소조사적1541례북경지구45 ～ 74세대렬인군중자료완정적1471인(남성688인,녀성783인)작위연구대상.Lp-PLA2활성수평채용비색법진행검측.대남녀량성적Lp-PLA2활성수평이급Lp-PLA2활성여위험인소적관계진행료분석.결과 (1)남녀량성Lp-PLA2활성수평분별위(22.73±8.52) nmol·min-1 ·ml-1화(20.01±8.06) nmol·min-1·ml-(P＜0.01).(2)남성적년령、요위、수축압、서장압이급고혈압환병솔고우녀성,녀성적총담고순(TC)、저밀도지단백담고순(LDL-C)、고밀도지단백담고순(HDL-C)고우남성(P＜0.05혹P＜0.01).(3)Pearson상관분석현시,남성Lp-PLA2활성수평여비반지표(요위화체질지수)、혈압(수축압화서장압)、혈지(TC、LDL-C、HDL-C화감유삼지)균상관(P균＜0.01);녀성Lp-PLA2활성수평여년령화혈지상관(P＜0.05혹P＜0.01),이여비반지표화혈압적상관성저우남성(녀성r치0.02～0.08;남성r치0.10～0.16).다인소logistic회귀분석조정년령、요위、수축압、공복혈당、LDL-C、HDL-C、감유삼지화고민C반응단백후,남성Lp-PLA2활성수평잉고우녀성(OR=1.72,95％CI:1.34 ～2.21,P＜0.01).결론 남성적Lp-PLA2활성수평고우녀성,차여주요심혈관병위험인소적관계교강,단차성별차이병불능구완전유주요위험인소해석.
Objective To explore the impact of gender on lipoprotein-associated phospholipase A2 (Lp-PLA2) activity and association with known cardiovascular risk factors.Methods Participants in this study were recruited from Beijing sub-cohort from the Chinese Multi-provincial Cohort Study (CMCS) database.A total of 1471 participants with complete laboratory data were included in the study (688 male).Lp-PLA2 activity was determined by colorimetric assay kit.Lp-PLA2 activity level and correlation between Lp-PLA2 activity and known risk factors were compared between men and women.Results (1) Lp-PLA2 activity was higher in males than in females [(22.73 ±8.52) nmol· min-1 · ml-1 vs.(20.01 ±8.06) nmol · min-1 · ml-1,P ＜ 0.01].(2) Age,waist circumference,systolic blood pressure,diastolic blood pressure and the prevalence of hypertension were higher in males than in females,while total cholesterol,low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were higher in females than in males(P ＜ 0.05 or P ＜ 0.01).(3)Pearson correlation showed that Lp-PLA2 activity was correlated with lipids (total cholesterol,LDL-C,HDL-C,and triglyceride),blood pressure (systolic blood pressure and diastolic blood pressure),and adiposity associated parameters (waist circumference and body mass index) in males(all P ＜0.01) and was correlated with lipid level (total cholesterol,LDL-C,HDL-C,and triglyceride) and age in females(P ＜ 0.05 or P ＜ 0.01).Correlations with variables associated with obesity or blood pressure in females were much weaker than those in males (in females,r =0.02-0.08 ; in males,r =0.10-0.16).(4) After adjustment for age,waist circumference,systolic blood pressure,glucose,LDL-C,HDL-C,triglyceride and high sensitivity C-reactive protein by multiple logistic regression model,Lp-PLA2 activity was still significantly higher in males than in females (OR =1.72,95％ confidence interval =1.34-2.21,P ＜ 0.01).Conclusions Lp-PLA2 activity and association with known cardiovascular risk factors differed in males and females.The gender difference in Lp-PLA2 activity still presents after adjustment for known cardiovascular risk factors in this cohort.