CAJ | 학술논문

目的探讨我国40岁及以上中老年人血浆N末端B型利钠肽原(NT-proBNP)的正常参考值范围.方法采用电化学发光免疫学方法,测定上海心脏健康研究(SHHS)队列基线调查中5133例健康中老年人血浆NT-proBNP水平.其中,男性2170例,女性2963例.分别采用分位数回归和经验方法估计正常参考值范围(第2.5百分位数～第97.5百分位数).结果不同年龄段女性的NT-proBNP水平均高于男性(P均＜0.01);无论是男性还是女性,NT-proBNP水平均随着年龄的增加而升高,NT-proBNP的自然对数与年龄呈线性相关(P均＜0.01).分位数回归估计的NT-proBNP正常参考值范围40 ～ 44、45 ～ 49、50 ～ 54、55 ～ 59、60 ～ 64、65 ～ 69、70 ～ 74、≥75岁男性分别为4.5～86.8、5.4～ 108.5、6.6 ～ 135.5、7.9～169.4、9.6 ～ 211.7、11.7 ～ 264.6、14.2～330.7、18.1 ～ 429.2ng/L,女性分别为8.5 ～141.8、10.4 ～166.6、12.8～ 195.7、15.7～229.9、19.3 ～270.1、23.7 ～ 317.3、29.1 ～ 372.8、35.7 ～ 451.9 ng/L.结论本研究初步建立了我国40岁及以上中老年人血浆NT-proBNP的正常参考值范围.
목적 탐토아국40세급이상중노년인혈장N말단B형리납태원(NT-proBNP)적정상삼고치범위.방법 채용전화학발광면역학방법,측정상해심장건강연구(SHHS)대렬기선조사중5133례건강중노년인혈장NT-proBNP수평.기중,남성2170례,녀성2963례.분별채용분위수회귀화경험방법고계정상삼고치범위(제2.5백분위수～제97.5백분위수).결과 불동년령단녀성적NT-proBNP수평균고우남성(P균＜0.01);무론시남성환시녀성,NT-proBNP수평균수착년령적증가이승고,NT-proBNP적자연대수여년령정선성상관(P균＜0.01).분위수회귀고계적NT-proBNP정상삼고치범위40 ～ 44、45 ～ 49、50 ～ 54、55 ～ 59、60 ～ 64、65 ～ 69、70 ～ 74、≥75세남성분별위4.5～86.8、5.4～ 108.5、6.6 ～ 135.5、7.9～169.4、9.6 ～ 211.7、11.7 ～ 264.6、14.2～330.7、18.1 ～ 429.2ng/L,녀성분별위8.5 ～141.8、10.4 ～166.6、12.8～ 195.7、15.7～229.9、19.3 ～270.1、23.7 ～ 317.3、29.1 ～ 372.8、35.7 ～ 451.9 ng/L.결론 본연구초보건립료아국40세급이상중노년인혈장NT-proBNP적정상삼고치범위.
Objective To establish the normal ranges for plasma N-terminal-pro-B-type natriuretic peptide (NT-proBNP) of middle-aged and elderly (≥40 years) healthy subjects in China.Methods A total of 5133 subjects (2170 men and 2963 women) from the cohort of Shanghai Heart Health Study (SHHS) were included in this study.Plasma NT-proBNP was measured by electrochemiluminescence immunoassay.The reference values (2.5th-97.5th quartiles) were determined using both empiric and quantile regression methods.Results Plasma NT-proBNP values were higher in women than in men at all respective age groups(all P ＜ 0.01),and natural log-transformed NT-proBNP values increased in proportion with age for both genders and there was a lineal correlation between natural log-transformed NT-proBNP values and age (all P ＜ 0.01).Quantile regression derived normal reference values for NT-proBNP in male were 4.5-86.8 ng/L in the 40-44 years old group,5.4-108.5 ng/L in the 45-49 years old group,6.6-135.5 ng/L in the 50-54 years old group,7.9-169.4 ng/L in the 55-59 years old group,9.6-211.7 ng/L in the 60-64 years old group,11.7-264.6 ng/L in the 65-69 years old group,14.2-330.7 ng/L in the 70-74 years old group,and 18.1-429.2 ng/L in the ≥75 years old group.The reference values in female for NT-pro-BNP in respective age group were 8.5-141.8 ng/L,10.4-166.6 ng/L,12.8-195.7 ng/L,15.7-229.9 ng/L,19.3-270.1 ng/L,23.7-317.3 ng/L,29.1-372.8 ng/L,and 35.7-451.9 ng/L.Conclusion This study preliminarily establishes the normal ranges of plasma NT-proBNP in middle-aged and elderly (≥40 years) Chinese.