CAJ | 학술논문

目的分析1992至2007年多省市队列人群血清总胆固醇(TC)水平及高胆固醇血症患病率的变化特点.方法 1992年,在多省市35 ～64岁人群中进行基线危险因素调查,并建立心血管病研究队列.2007年,在该队列人群中再次组织危险因素调查.2次调查资料均完整的调查对象共5 740名,对其血清TC进行分析.结果 (1)1992至2007年,平均TC水平男性从4.65 mmol/L增加到4.96 mmol/L,女性从4.40 mmol/L增加到5.35 mmol/L.高胆固醇患病率男性从5.1％(141/2 791)上升到8.5％(237/2 791),女性从4.9％(143/2949)上升到20.0％(590/2949).(2)在不同性别中,女性基线时35 ～44岁年龄段人群平均TC水平增加值最大,为0.95 mmol/L.在不同地区中,基线时TC平均值最低的农村人群平均TC水平增加值最大,为0.88 mmol/L.以1992年基线TC水平5分位切点分层,男女两性均是最低分位组平均TC水平增加值最大,分别为0.93 mmol/L和1.45 mmol/L.(3)在2007年的高胆固醇血症患者中,36.5％ (302/827)来源于基线TC5.18～6.21 mmol/L人群,49.6％(41 0/827)来源于基线TC ＜5.18 mmol/L人群.结论 1992至2007年,队列人群平均TC水平男女两性均增高；农村以及基线TC水平最低分位组人群TC水平上升幅度最大.
목적 분석1992지2007년다성시대렬인군혈청총담고순(TC)수평급고담고순혈증환병솔적변화특점.방법 1992년,재다성시35 ～64세인군중진행기선위험인소조사,병건립심혈관병연구대렬.2007년,재해대렬인군중재차조직위험인소조사.2차조사자료균완정적조사대상공5 740명,대기혈청TC진행분석.결과 (1)1992지2007년,평균TC수평남성종4.65 mmol/L증가도4.96 mmol/L,녀성종4.40 mmol/L증가도5.35 mmol/L.고담고순환병솔남성종5.1％(141/2 791)상승도8.5％(237/2 791),녀성종4.9％(143/2949)상승도20.0％(590/2949).(2)재불동성별중,녀성기선시35 ～44세년령단인군평균TC수평증가치최대,위0.95 mmol/L.재불동지구중,기선시TC평균치최저적농촌인군평균TC수평증가치최대,위0.88 mmol/L.이1992년기선TC수평5분위절점분층,남녀량성균시최저분위조평균TC수평증가치최대,분별위0.93 mmol/L화1.45 mmol/L.(3)재2007년적고담고순혈증환자중,36.5％ (302/827)래원우기선TC5.18～6.21 mmol/L인군,49.6％(41 0/827)래원우기선TC ＜5.18 mmol/L인군.결론 1992지2007년,대렬인군평균TC수평남녀량성균증고；농촌이급기선TC수평최저분위조인군TC수평상승폭도최대.
Objective To describe the changes of serum total cholesterol (TC) and the prevalence of hypercholesterolemia from 1992 to 2007 in the general population from Chinese multi-provincial cohort study (CMCS).Methods CMCS database were established on participants aged 35-64 years from 11 provinces during the baseline examination on cardiovascular risk factors in 1992.Participants were followed up and invited to re-examine risk factors in 2007.Five thousand seven hundred and forty participants with complete data from these two examinations were included in this study for investigating the changes of serum TC level.Results (1) From 1992 to 2007,the mean level of TC increased from 4.65 mmol/L to 4.96 mmol/L for men,and from 4.40 mmol/L to 5.35 mmol/L for women.The prevalence of hypercholesterolemia increased from 5.1％ (141/2 791) to 8.5％ (237/2 791) in men,and from 4.9％ (143/2 949) to 20.0％ (590/2 949) in women.(2)Stratified by sex and age,the maximum increase in TC of 0.95 mmol/L was observed in women aged 35-44 years.Stratified by district,the maximum increase in TC of 0.88 mmol/L was observed in participants who had low baseline TC level living at rural area.Furthermore,baseline TC level was categorized into quintiles,the increases in TC level were highest in the lowest quintile both in men and women (0.93 mmol/L and 1.45 mmol/L,respectively).(3) Thirty-six point five percent (302/827)participants with hypercholesterolemia in 2007 developed from those with baseline TC 5.18-6.21 mmol/L,and 49.6％ (410/827) developed from those with baseline TC ＜ 5.18 mmol/L.Conclusions From 1992 to 2007,the mean level of TC increased in both men and women.The greatest increases in TC were observed in the participants with the lowest quintile of baseline TC and those living in the rural area.