CAJ | 학술논문

目的探讨超声支气管镜引导下针吸活检术(EBUS-TBNA)超声影像特征对肺癌纵隔/肺门淋巴结的诊断价值.方法回顾性分析2009年10月至2011年9月422例经EBUS-TBNA检查术前未经抗肿瘤治疗的肺癌患者,病理明确诊断为肺癌且术后6个月随访胸部增强CT.肺癌患者683个纵隔/肺门淋巴结入组研究,其中男335例,女87例;年龄24～82岁,中位61岁,EBUS淋巴结超声图像结果与最终病理、随访结果进行比较.结果 683个淋巴结短轴直径0.40～4.60 cm,平均直径(1.58±0.68) cm;其中恶性淋巴结短轴平均直径(1.75 ±0.63) cm,良性淋巴结短轴平均直径(0.92±0.40)cm.超声图像下异质性淋巴结527个,其中恶性淋巴结519/527(98.5％);均质性淋巴结156个,其中恶性淋巴结28/156(17.9％),两种超声图像差异有高度统计学意义(x2=489.5,P＜0.01).短轴直径＞1.0 cm异质性淋巴结是恶性的敏感性89.4％,特异性100％,准确性89.6％.结论 EBUS-TBNA是纵隔/肺门淋巴结活检的一种新手段,基于EBUS成像分类为基础的淋巴结超声图像特征,可用于指导淋巴结穿刺顺序,预测肺癌患者淋巴结的良恶性.
목적 탐토초성지기관경인도하침흡활검술(EBUS-TBNA)초성영상특정대폐암종격/폐문림파결적진단개치.방법 회고성분석2009년10월지2011년9월422례경EBUS-TBNA검사술전미경항종류치료적폐암환자,병리명학진단위폐암차술후6개월수방흉부증강CT.폐암환자683개종격/폐문림파결입조연구,기중남335례,녀87례;년령24～82세,중위61세,EBUS림파결초성도상결과여최종병리、수방결과진행비교.결과 683개림파결단축직경0.40～4.60 cm,평균직경(1.58±0.68) cm;기중악성림파결단축평균직경(1.75 ±0.63) cm,량성림파결단축평균직경(0.92±0.40)cm.초성도상하이질성림파결527개,기중악성림파결519/527(98.5％);균질성림파결156개,기중악성림파결28/156(17.9％),량충초성도상차이유고도통계학의의(x2=489.5,P＜0.01).단축직경＞1.0 cm이질성림파결시악성적민감성89.4％,특이성100％,준학성89.6％.결론 EBUS-TBNA시종격/폐문림파결활검적일충신수단,기우EBUS성상분류위기출적림파결초성도상특정,가용우지도림파결천자순서,예측폐암환자림파결적량악성.
Objective To investigate the diagnostic value of EBUS imaging features for metastatic mediastinal/hilar lymph node enlargement in lung cancer.Methods The lung cancer patients with a pathological diagnosis and without preoperative anti-tumor treatment who got the EBUS-TBNA examination from October 2009 to September 2011 were retrospectively analysis.422 lung cancer patients with 683 mediastinal / hilar lymph nodes were enrolled in this study,including 335 males and 87 females; the median age is 61 years old (range 24-82),EBUS lymph node ultrasound image and the final pathological or follow-up results were compared by the statistical analysis.Homogeneity in the lymph node EBUS image feature was defined as:uniform echo in the ultrasound images,cortex existed in the peripheral areas,medulla existed in lymph central with a slightly stronger echo and represent as a small strip.Heterogeneity was defined as: the ultrasound image was defined as uneven echo involved with coagulation necrosis sign,which was the hypoechoic areas without blood flow in the lymph nodes and represent no blood flow in the CDPI mode.The coagulation necrosis was associated with necrosis within the lymph node.In addition,if the CNS region occupied more than 11％ of the entire lymph node in a complete lymph node or just a part of huge lymph nodes in the EBUS imaging window frame,we also regard it as heterogeneity.If a complete lymph node was seen in the EBUS imaging window frame,we measured the longest diameter to the long axis and its vertical maximum diameter to the short axis.If the lymph node was huge and extended the EBUS imaging window frame,we measured the longest diameter in the frame as the long axis of its vertical maximum diameter to be the short axis.As to the EBUS-TBNA negative lymph nodes,we regarded it was malignant lymph node if the diameter of the lymph node increased by 20％ in the patients who did not received any chemotherapy or radiotherapy or the diameter of the lymph node increased or decreased by 20％ in the patients who received any chemotherapy or radiotherapy six month later in the chest enhanced CT scan,otherwise,it was identified as benign lymph node.We used the RECIST 1.1 solid tumors criteria to evaluate the efficacy of the chemotherapy.Results 422 patients were enrolled this study including 93 squamous carcinomas,137 adenocarcinomas,97 small cell lung cancer,42 poorly differentiated non-small cell lung cancer,29 adenosquamous carcinoma and 24 other malignant tumors (including large cell carcinoma,sarcomatoid carcinoma,carcinoid tumors,etc).The sensitivity of the EBUS-TBNA was 93.8％ (396/422).The diagnostic methods and results in the 683 lymph nodes were as the following: 506/683 (74.1％) was confirmed as cancer by the EBUS-TBNA while 177/683 (25.9％) was diagnosed as benign disease.Among these,32/683 (4.7％) was confirmed as cancer and 57/683 (8.3％)was confirmed as benign disease by surgery,9/683 (1.3％) was confirmed as cancer and 79/683 (11.6％) was confirmed as benign disease by the method of follow-up.the sensitivity for the EBUS-TBNA to be malignant was 506/547 (92.5 ％),specificity was 136/136 (100％),positive predictive value was 506/506 (100％),negative predictive value was 136/177(76.8％) and accuracy was 642/683 (94.0％).The short axis diameter in the 683 lymph nodes ranged from 0.40cm to 4.60cm with an average diameter of (1.58 ± 0.68) cm.Among them,the short axis diameter in the malignant lymph node was (1.75 ± 0.63) cm,and in the benign lymph nodes was (0.92 ± 0.40) cm.527 lymph nodes presented heterogeneity under the ultrasound imaging,in which,519/527 (98.5 ％)were malignant lymph nodes.While,156 lymph nodes presented homogeneity and 28/156 (17.9％) were malignant lymph nodes (x2 =489.5,P ＜0.01).In the heterogeneous lymph node with a short axis diameter more than 1.0cm,the sensitivity to be malignant was 89.4％,specificity was 100％ and accuracy was 89.6％.In the homogeneous lymph node with a short axis diameter less than 0.8cm,the sensitivity to be benign was 43.8％,specificity was 67.8％ and accuracy was 48.1％.Conclusion EBUS-TBNA is new biopsy method for the mediastinal / hilar lymph node.The classification based on EBUS imaging-based lymph node ultrasound image features was helpful to identify the procedure for the diagnostic purposes and could help to distinguish the benign or malignant mediastinal / hilar lymph node in lung cancer patients.