CAJ | 학술논문

目的建立兔早期急性心肌缺血模型,通过测量应变、应变率及纵向旋转角度等指标判断兔早期急性心肌缺血时心脏功能的变化.方法新西兰大白兔48只,常规测量其左心室壁各节段的径向收缩期峰值应变及收缩期、舒张早期、舒张晚期的径向峰值应变率,左心室壁各节段及整体的峰值旋转角度.常规麻醉,开胸后结扎左前降支,关胸10 min后测量术前相同指标,比较二者间差异.结果心率(HR)、左心房内径(LAD)及左心室射血分数(LVEF)在手术前、后的差异有统计学意义,且术后指标明显低于术前.各室壁径向收缩期峰值应变率在手术前、后的差异有统计学意义(P＜0.05),而径向收缩期峰值应变、舒张期峰值应变率的差异无统计学意义,但术后指标稍低于术前.对手术前、后各室壁节段性旋转及整体旋转角度的比较,显示术前左心室侧壁基底段的旋转角度与术后的差异有统计学意义[(4.42±4.99)°对(1.17 ±5.07)°,P＜0.05],而其余室壁的旋转角度及左心室整体的旋转角度的比较均无统计学意义(P＞0.05),但术后指标均低于术前.结论兔早期急性心肌缺血时心肌收缩功能发生改变,径向收缩期峰值应变率可以较为敏感的反映,左心室侧壁基底段旋转角度的改变也可能是反映心肌早期急性缺血的指标.
목적 건립토조기급성심기결혈모형,통과측량응변、응변솔급종향선전각도등지표판단토조기급성심기결혈시심장공능적변화.방법 신서란대백토48지,상규측량기좌심실벽각절단적경향수축기봉치응변급수축기、서장조기、서장만기적경향봉치응변솔,좌심실벽각절단급정체적봉치선전각도.상규마취,개흉후결찰좌전강지,관흉10 min후측량술전상동지표,비교이자간차이.결과 심솔(HR)、좌심방내경(LAD)급좌심실사혈분수(LVEF)재수술전、후적차이유통계학의의,차술후지표명현저우술전.각실벽경향수축기봉치응변솔재수술전、후적차이유통계학의의(P＜0.05),이경향수축기봉치응변、서장기봉치응변솔적차이무통계학의의,단술후지표초저우술전.대수술전、후각실벽절단성선전급정체선전각도적비교,현시술전좌심실측벽기저단적선전각도여술후적차이유통계학의의[(4.42±4.99)°대(1.17 ±5.07)°,P＜0.05],이기여실벽적선전각도급좌심실정체적선전각도적비교균무통계학의의(P＞0.05),단술후지표균저우술전.결론 토조기급성심기결혈시심기수축공능발생개변,경향수축기봉치응변솔가이교위민감적반영,좌심실측벽기저단선전각도적개변야가능시반영심기조기급성결혈적지표.
Objective To assess the left ventricular function and longitudinal rotation in rabbits after acute occlusion of left anterior descending artery by two-dimensional speckle tracking imaging (2D-STI).Methods 48 New Zealand white rabbits underwent conventional echocardiography examination,using Echopac to measure the left ventricular peak radial systolic strain and strain rate,peak radial diastolic strain rate,the segmental and total longitudinal rotational degrees,then anesthesia,thoracotomy,ligation of the left anterior descending artery,closed chest,after 10 miniutes to measure the same indicator in the preoperative,and to compare the difference between the measured values.Results (1) The difference in HR,LAD,and LVEF between preoperative and postoperative were significant,the value which measured postoperative is significant lower than preoperative.(2)The peak systolic radial strain rate in postoperative is significant lower than preoperative.And there were no difference between preoperative and postoperative in peak systolic radial strain,peak diastolic radial strain rate.(3)The rotation degrees of the left ventricular lateral basal wall between preoperative and postoperative had significant difference[(4.42 ±4.99) °,(1.17 ± 5.07) o,p ＜ 0.05],while the other walls and the longitudinal rotational degrees had no difference,but the value which measured postoperative is lower than the preoperative.Conclusion In this paper,after acute occlusion of left anterior descending artery,evaluate the changes in cardiac function in early acute myocardial ischemia in rabbits,the peak radial systolic strain rate in left ventricular can be a sensitive change in detecting the LV function,and also rotational degrees desending of the basal lateral wall can be another indicator to reflect the function change in the early phase of acute myocardial iscbemia.