CAJ | 학술논문

目的探讨原癌基因△Np63α在食管鳞癌中的表达及与临床预后的相关性.方法应用免疫组织化学SABC法检测304例食管鳞癌组织中△Np63α表达水平及与临床病理的相关性.结果食管鳞癌组织中△Np63α阳性表达为40％(122/304例)；与癌旁组织比较,差异有统计学意义(P=0.034).△Np63α表达水平与淋巴结转移、分化程度、浸润深度、TNM分期、VEGF表达均明显相关(P=0.001).多因素统计分析提示△Np63α阳性是食管鳞癌预后的独立危险因素(P=0.001).结论 △Np63α阳性表达与肿瘤的复发、转移密切相关.
목적 탐토원암기인△Np63α재식관린암중적표체급여림상예후적상관성.방법 응용면역조직화학SABC법검측304례식관린암조직중△Np63α표체수평급여림상병리적상관성.결과 식관린암조직중△Np63α양성표체위40％(122/304례)；여암방조직비교,차이유통계학의의(P=0.034).△Np63α표체수평여림파결전이、분화정도、침윤심도、TNM분기、VEGF표체균명현상관(P=0.001).다인소통계분석제시△Np63α양성시식관린암예후적독립위험인소(P=0.001).결론 △Np63α양성표체여종류적복발、전이밀절상관.
Objective The aim of this study was to assess the value of △Np63α in predicting tumor recurrence after curative resection in esophageal squamous cell carcinoma (ESCC) patients.Methods We analyzed △Np63α protein cxpression in 304 clinicopathologically characterized ESCC cases by immunohistochemistry.Results We found △Np63α expression was positive in 122 (40％) of 304 cases.△Np63α expression was higher in the cancer tissue than in non-tumorous control tissue at protein level(P =0.034).There was a significant difference of △Np63α expression in patients categorized according to invasive depth (P =0.001),tumor position (P =0.001) and lymph nodes metastasis condition (P =0.001).Multivariate analyses showed that △Np63α was an independent prognostic marker for ESCC recurrence.Conclusion △Np63α is associated with outcome of ESCC and can be a novel predictor for poor prognosis of ESCC patients after curative resection.