中华血液学杂志
中華血液學雜誌
중화혈액학잡지
Chinese Journal of Hematology
2013年
2期
133-137
,共5页
苏龙%高素君%李薇%谭业辉%姚程%宋艳秋%杨岩%刘子玲%白欧%林海%杨雷%王畅%崔久巍%王冠军
囌龍%高素君%李薇%譚業輝%姚程%宋豔鞦%楊巖%劉子玲%白歐%林海%楊雷%王暢%崔久巍%王冠軍
소룡%고소군%리미%담업휘%요정%송염추%양암%류자령%백구%림해%양뢰%왕창%최구외%왕관군
白血病,髓样,急性%细胞遗传学%年龄组
白血病,髓樣,急性%細胞遺傳學%年齡組
백혈병,수양,급성%세포유전학%년령조
Leukemia,myeloid,acute%Cytogenetics%Age groups
目的 分析不同年龄组急性髓系白血病(AML)患者细胞遗传学特点,探究AML细胞遗传学与患者年龄的相关性.方法 回顾分析2004年1月至2011年12月初诊原发AML患者640例.收集患者治疗前骨髓标本,采用G显带技术分析染色体核型,核型异常按<人类细胞遗传学国际命名体制(ISCN 2009)>进行识别和描述.结果 正常核型、平衡核型及非平衡核型呈现不同的年龄分布特征.随年龄增加,正常核型的比例从6.67%(0~9岁组)升高到58.33%(≥70岁组)(χ2=20.68,P=0.001),平衡核型的发生率从73.33%(0~9岁组)降低到11.11%(≥70岁组)(χ2=48.22,P<0.01),非平衡核型的发生率从3.39%(10~19岁组)上升到30.56%(≥70岁组)(χ2=18.92,P=0.004);复杂核型在0~9岁组的发生率为6.67%,10~19岁组及20~29岁组未检出,从30~39岁组到≥70岁组,其发生率由1.72%升高到11.11%(χ2=8.34,P=0.080);单体型核型在30岁以下组未检出,30岁以上组其发生率随年龄增加虽有上升趋势,但差异无统计学意义(χ2=4.78,P=0.311).结论 不同染色体核型具有不同的年龄分布特征,这可能为AML病因学研究及预防提供有益参考.
目的 分析不同年齡組急性髓繫白血病(AML)患者細胞遺傳學特點,探究AML細胞遺傳學與患者年齡的相關性.方法 迴顧分析2004年1月至2011年12月初診原髮AML患者640例.收集患者治療前骨髓標本,採用G顯帶技術分析染色體覈型,覈型異常按<人類細胞遺傳學國際命名體製(ISCN 2009)>進行識彆和描述.結果 正常覈型、平衡覈型及非平衡覈型呈現不同的年齡分佈特徵.隨年齡增加,正常覈型的比例從6.67%(0~9歲組)升高到58.33%(≥70歲組)(χ2=20.68,P=0.001),平衡覈型的髮生率從73.33%(0~9歲組)降低到11.11%(≥70歲組)(χ2=48.22,P<0.01),非平衡覈型的髮生率從3.39%(10~19歲組)上升到30.56%(≥70歲組)(χ2=18.92,P=0.004);複雜覈型在0~9歲組的髮生率為6.67%,10~19歲組及20~29歲組未檢齣,從30~39歲組到≥70歲組,其髮生率由1.72%升高到11.11%(χ2=8.34,P=0.080);單體型覈型在30歲以下組未檢齣,30歲以上組其髮生率隨年齡增加雖有上升趨勢,但差異無統計學意義(χ2=4.78,P=0.311).結論 不同染色體覈型具有不同的年齡分佈特徵,這可能為AML病因學研究及預防提供有益參攷.
목적 분석불동년령조급성수계백혈병(AML)환자세포유전학특점,탐구AML세포유전학여환자년령적상관성.방법 회고분석2004년1월지2011년12월초진원발AML환자640례.수집환자치료전골수표본,채용G현대기술분석염색체핵형,핵형이상안<인류세포유전학국제명명체제(ISCN 2009)>진행식별화묘술.결과 정상핵형、평형핵형급비평형핵형정현불동적년령분포특정.수년령증가,정상핵형적비례종6.67%(0~9세조)승고도58.33%(≥70세조)(χ2=20.68,P=0.001),평형핵형적발생솔종73.33%(0~9세조)강저도11.11%(≥70세조)(χ2=48.22,P<0.01),비평형핵형적발생솔종3.39%(10~19세조)상승도30.56%(≥70세조)(χ2=18.92,P=0.004);복잡핵형재0~9세조적발생솔위6.67%,10~19세조급20~29세조미검출,종30~39세조도≥70세조,기발생솔유1.72%승고도11.11%(χ2=8.34,P=0.080);단체형핵형재30세이하조미검출,30세이상조기발생솔수년령증가수유상승추세,단차이무통계학의의(χ2=4.78,P=0.311).결론 불동염색체핵형구유불동적년령분포특정,저가능위AML병인학연구급예방제공유익삼고.
Objective To analyze the cytogenetic characteristics of different age subgroups in patients with acute myeloid leukemia (AML), and to explore the relationship between age and cytogenetics. Methods Between January 2004 and December 2011, Bone marrow(BM) samples from 640 patients with de novo AML were analyzed retrospectively. The analyses were performed according to standard culturing and banding techniques, and clonal abnormalities were defined and described according to the International System for Human Cytogenetic Nomenclature (ISCN 2009). The cytogenetic subtypes were performed as normal, balanced, and unbalanced karyotypes. In the last group, the age distribution of complex and monosomal karyotypes were further analyzed. The patients were divided into 8 age groups: 0-9, 10-19, 20-29, 30-39, 40-49, 50-59, 60-69, and ≥70 year old groups. Results The distribution of normal, balanced, and unbalanced karyotypes showed age specific characteristics. The incidence of normal karyotype increased from 6.67%(0~9 year old) to 58.33%(≥70)(χ2 =20.68, P=0.001) and balanced karyotype decreased from 73.33%(0~9) to 11.11% (≥70) (χ2 =48.22, P< 0.01). The frequency of unbalanced karyotypes increased from 20.0%(0~9) to 30.56%(≥70) (χ2 =18.963, P=0.008). The frequency of complex karyotype was 6.67% in 0-9 year old group, followed by 0% in 10-19 and 20-29 year old group, and from 1.72% to 11.11% from 30-39 to ≥70 year old group (χ2 =8.341, P=0.08). Monosomal karyotype was only detected in patients in 30 year old or older groups. Although an increased tendency was observed with ages, there was no significant difference (χ2 =4.778, P=0.311). Conclusion The different age profiles of the cytogenetic subtypes may indicate the different mechanisms of the pathogenesis of AML, which may also offer beneficial information for etiological research of AML.
