CAJ | 학술논문

目的探讨异基因造血干细胞移植(allo-HSCT)后并发格林-巴利综合征(GBS)的临床特点、治疗及预后.方法报告2例allo-HSCT后并发GBS患者并复习相关文献,探讨其临床特点、治疗及预后.结果 2例患者移植后2个月出现感觉障碍及进行性肌无力,经头颅磁共振成像、脑脊液、肌电图等检查诊断为GBS.经糖皮质激素、静脉丙种球蛋白及血浆置换治疗,2例患者均因病情进展死亡.结论 GBS是allo-HSCT后的罕见并发症.目前的主要治疗方法是静脉丙种球蛋白及血浆置换.由于存在恶性原发病,免疫低下且往往合并感染、移植物抗宿主病等其他并发症,allo-HSCT后并发GBS患者预后不良.
목적 탐토이기인조혈간세포이식(allo-HSCT)후병발격림-파리종합정(GBS)적림상특점、치료급예후.방법 보고2례allo-HSCT후병발GBS환자병복습상관문헌,탐토기림상특점、치료급예후.결과 2례환자이식후2개월출현감각장애급진행성기무력,경두로자공진성상、뇌척액、기전도등검사진단위GBS.경당피질격소、정맥병충구단백급혈장치환치료,2례환자균인병정진전사망.결론 GBS시allo-HSCT후적한견병발증.목전적주요치료방법시정맥병충구단백급혈장치환.유우존재악성원발병,면역저하차왕왕합병감염、이식물항숙주병등기타병발증,allo-HSCT후병발GBS환자예후불량.
Objective To investigate the clinical characteristics,treatment and prognosis of Guillain-Barre syndrome (GBS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT).Methods Two cases with GBS after allo-HSCT were admitted to our hospital and a review of literatures concerning GBS developed after allo-HSCT.The clinical characteristics,treatment and prognosis were investigated.Results Two patients experienced sensory disturbance and progressive muscle weakness 2 months after HSCT.The diagnosis of GBS was established after cranial MRI,lumbar puncture and EMG.Both patients died of GBS progression even after the treatment of steroid,intravenous immunoglobulin (IVIG) and plasma exchange.Conclusion GBS was a rare complication after allo-HSCT.The commonclinical practices in treating GBS included IVIG and plasma exchange.Due to the primary malignant disease and low immunity posttransplant,infection,GVHD and other complications,prognosis of GBS was poor with high mortality.