中华血液学杂志
中華血液學雜誌
중화혈액학잡지
Chinese Journal of Hematology
2014年
8期
743-746
,共4页
冯格格%王建虹%姜玉杰%李颖%丁梅%王娜%王欣
馮格格%王建虹%薑玉傑%李穎%丁梅%王娜%王訢
풍격격%왕건홍%강옥걸%리영%정매%왕나%왕흔
白血病,髓系,慢性,BCR-ABL阳性%Sokal积分%Hasford积分%EUTOS积分%伊马替尼
白血病,髓繫,慢性,BCR-ABL暘性%Sokal積分%Hasford積分%EUTOS積分%伊馬替尼
백혈병,수계,만성,BCR-ABL양성%Sokal적분%Hasford적분%EUTOS적분%이마체니
Leukemia,myelogenous,chronic,BCR-ABL positive%Sokal scoring system%Hasford scoring system%EUTOS scoring system%Imatinib
目的 比较Sokal、Hasford和EUTOS积分系统在慢性髓性白血病(CML)中的临床意义,为初诊慢性期CML患者的预后评估和治疗选择提供依据.方法 回顾性分析113例CML患者的临床及实验室检查资料,分别按照3种积分系统与不同治疗方案对患者进行分组,比较不同积分系统与治疗方案对CML患者生存期的影响.结果 3种积分系统均能显著区分各危险组患者生存期的差异,其中EUTOS积分系统可能更为准确.用Spearman相关性分析对3种积分系统进行比较,发现Sokal与Hasford间相关性较强(r=0.792,P＜0.01),而EUTOS与Hasford相关性次之(r=0.624,P＜0.01),Sokal与EUTOS间的相关性最弱(r=0.508,P＜0.01).接受伊马替尼治疗的Sokal、Hasford评分中低危组及EUTOS评分低危组患者生存期较接受羟基脲/干扰素治疗者明显延长,但不同治疗方案对Sokal、Hasford、EUTOS评分高危组患者生存期的影响并不明显.结论 3种积分系统均能较好预测CML患者的预后,EUTOS积分系统的预测意义可能更大.按照Sokal、Hasford、EUTOS积分系统将患者分组,有助于早期优化CML患者治疗,提高疗效.
目的 比較Sokal、Hasford和EUTOS積分繫統在慢性髓性白血病(CML)中的臨床意義,為初診慢性期CML患者的預後評估和治療選擇提供依據.方法 迴顧性分析113例CML患者的臨床及實驗室檢查資料,分彆按照3種積分繫統與不同治療方案對患者進行分組,比較不同積分繫統與治療方案對CML患者生存期的影響.結果 3種積分繫統均能顯著區分各危險組患者生存期的差異,其中EUTOS積分繫統可能更為準確.用Spearman相關性分析對3種積分繫統進行比較,髮現Sokal與Hasford間相關性較彊(r=0.792,P＜0.01),而EUTOS與Hasford相關性次之(r=0.624,P＜0.01),Sokal與EUTOS間的相關性最弱(r=0.508,P＜0.01).接受伊馬替尼治療的Sokal、Hasford評分中低危組及EUTOS評分低危組患者生存期較接受羥基脲/榦擾素治療者明顯延長,但不同治療方案對Sokal、Hasford、EUTOS評分高危組患者生存期的影響併不明顯.結論 3種積分繫統均能較好預測CML患者的預後,EUTOS積分繫統的預測意義可能更大.按照Sokal、Hasford、EUTOS積分繫統將患者分組,有助于早期優化CML患者治療,提高療效.
목적 비교Sokal、Hasford화EUTOS적분계통재만성수성백혈병(CML)중적림상의의,위초진만성기CML환자적예후평고화치료선택제공의거.방법 회고성분석113례CML환자적림상급실험실검사자료,분별안조3충적분계통여불동치료방안대환자진행분조,비교불동적분계통여치료방안대CML환자생존기적영향.결과 3충적분계통균능현저구분각위험조환자생존기적차이,기중EUTOS적분계통가능경위준학.용Spearman상관성분석대3충적분계통진행비교,발현Sokal여Hasford간상관성교강(r=0.792,P＜0.01),이EUTOS여Hasford상관성차지(r=0.624,P＜0.01),Sokal여EUTOS간적상관성최약(r=0.508,P＜0.01).접수이마체니치료적Sokal、Hasford평분중저위조급EUTOS평분저위조환자생존기교접수간기뇨/간우소치료자명현연장,단불동치료방안대Sokal、Hasford、EUTOS평분고위조환자생존기적영향병불명현.결론 3충적분계통균능교호예측CML환자적예후,EUTOS적분계통적예측의의가능경대.안조Sokal、Hasford、EUTOS적분계통장환자분조,유조우조기우화CML환자치료,제고료효.
Objective To compare the validity of three currently used chronic myeloid leukemia (CML) scoring systems (Sokal CML prognostic scoring system,Hasford prognostic scoring system,and EUTOS prognostic scoring system) in chronic phase CML (CP-CML) patients.Methods One hundred and thirteen CP-CML patients taking hydroxyurea,interferon or imatinib were enrolled in this study.All patients were stratified into different groups according to each scoring system and different therapies respectively.And overall survival (OS) rates were observed and compared among different groups.Results Three scoring systems were effective predictors of OS in CP-CML patients,and EUTOS scoring system may predict more validly.Hasford scoring system was well correlated with Sokal and EUTOS scores (r=0.792,P＜0.01 and r=0.624,P＜0.01).The correlation between Sokal and EUTOS scores was relatively weak (r=0.508,P＜0.01).Despite imatinib' s marked effect in prolonging survival of CML patients,it was incapable of prolonging survival in Sokal,Hasford and EUTOS high-risk patients.Conclusion EUTOS prognostic scoring system may predict better than Sokal and Hasford systems in CML patients.Classification of patients based on the three scoring systems may assist in the choice of appropriate therapy for CML.
