中华血液学杂志
中華血液學雜誌
중화혈액학잡지
Chinese Journal of Hematology
2014年
10期
909-913
,共5页
宋立娜%岑溪南%欧晋平%王文生%邱志祥%董玉君%梁赜隐%许蔚林%李渊
宋立娜%岑溪南%歐晉平%王文生%邱誌祥%董玉君%樑賾隱%許蔚林%李淵
송립나%잠계남%구진평%왕문생%구지상%동옥군%량색은%허위림%리연
淋巴瘤,大B细胞,弥漫性%胃肠道%抗肿瘤联合化疗方案%预后
淋巴瘤,大B細胞,瀰漫性%胃腸道%抗腫瘤聯閤化療方案%預後
림파류,대B세포,미만성%위장도%항종류연합화료방안%예후
Lymphoma,large B-cell,diffuse%Gastrointestinal tract%Antineoplastic combined chemotherapy protocols%Prognosis
目的 探讨影响原发胃肠道弥漫大B细胞淋巴瘤(PGI-DLBCL)患者预后生存的相关因素.方法 通过长期随访和收集85例PGI-DLBCL患者资料,分析患者的临床特征、治疗方案与其预后生存的相关性.结果 85例患者中男55例,女30例,男、女比例为1.83:1,中位发病年龄61 (18～87)岁.胃部发病63.5％ (54/85),肠道发病35.3％(30/85),胃肠道多部位发病1.2％ (1/85).骨髓侵犯16.4％ (11/64),幽门螺杆菌感染阳性率51.4％(19/37).全部患者5年总生存率为63.9％.胃部、肠道组患者5年总生存率分别为75.3％、44.1％,差异有统计学意义(P=0.005).生发中心来源(GCB)、非GCB组患者5年总生存率分别为64.7％、62.4％,差异无统计学意义(P=0.610).单因素分析显示影响患者总生存的因素包括年龄、病变部位、病变大小、胃肠道淋巴瘤Lugano分期、IPI评分(P值均＜0,05).多因素分析显示影响患者总生存的独立危险因素为IPI评分(RR=3.609,95 CI 2.034～6.404,P＜0.01).结论 IPI评分是影响PGI-DLBCL患者总生存的独立危险因素.
目的 探討影響原髮胃腸道瀰漫大B細胞淋巴瘤(PGI-DLBCL)患者預後生存的相關因素.方法 通過長期隨訪和收集85例PGI-DLBCL患者資料,分析患者的臨床特徵、治療方案與其預後生存的相關性.結果 85例患者中男55例,女30例,男、女比例為1.83:1,中位髮病年齡61 (18～87)歲.胃部髮病63.5％ (54/85),腸道髮病35.3％(30/85),胃腸道多部位髮病1.2％ (1/85).骨髓侵犯16.4％ (11/64),幽門螺桿菌感染暘性率51.4％(19/37).全部患者5年總生存率為63.9％.胃部、腸道組患者5年總生存率分彆為75.3％、44.1％,差異有統計學意義(P=0.005).生髮中心來源(GCB)、非GCB組患者5年總生存率分彆為64.7％、62.4％,差異無統計學意義(P=0.610).單因素分析顯示影響患者總生存的因素包括年齡、病變部位、病變大小、胃腸道淋巴瘤Lugano分期、IPI評分(P值均＜0,05).多因素分析顯示影響患者總生存的獨立危險因素為IPI評分(RR=3.609,95 CI 2.034～6.404,P＜0.01).結論 IPI評分是影響PGI-DLBCL患者總生存的獨立危險因素.
목적 탐토영향원발위장도미만대B세포림파류(PGI-DLBCL)환자예후생존적상관인소.방법 통과장기수방화수집85례PGI-DLBCL환자자료,분석환자적림상특정、치료방안여기예후생존적상관성.결과 85례환자중남55례,녀30례,남、녀비례위1.83:1,중위발병년령61 (18～87)세.위부발병63.5％ (54/85),장도발병35.3％(30/85),위장도다부위발병1.2％ (1/85).골수침범16.4％ (11/64),유문라간균감염양성솔51.4％(19/37).전부환자5년총생존솔위63.9％.위부、장도조환자5년총생존솔분별위75.3％、44.1％,차이유통계학의의(P=0.005).생발중심래원(GCB)、비GCB조환자5년총생존솔분별위64.7％、62.4％,차이무통계학의의(P=0.610).단인소분석현시영향환자총생존적인소포괄년령、병변부위、병변대소、위장도림파류Lugano분기、IPI평분(P치균＜0,05).다인소분석현시영향환자총생존적독립위험인소위IPI평분(RR=3.609,95 CI 2.034～6.404,P＜0.01).결론 IPI평분시영향PGI-DLBCL환자총생존적독립위험인소.
Objective To analyze the clinical characteristics,prognostic factors in patients with primary gastrointestinal diffuse large B cell lymphoma (PGI-DLBCL).Methods Long term follow-up of 85 patients with PGI-DLBCL was carried out and the patients clinical data were retrospectively evaluated.The risk factors for survival rate were analyzed by univariate and multivariate Cox regression analysis.Results The median age of 85 patients was 61 years old (18-87),and male:female ratio was 1.83∶1 (55/30).The stomach origin accounted for 63.5％ (54/85),intestine origin for 35.3％ (30/85) and multiple GI involvements for 1.2％ (1/85).Bone marrow involvement accounted for 16.4％ (11/64),Helicobacter pylori (HP) infection for 51.4％ (19/37).The 5-year overall survival (OS) rates of all patients were 63.9％.The 5-year OS of patients in stomach and intestinal groups were 75.3％ and 44.1％,respectively (P=0.005).The 5-year OS of germinal center B cell-like (GCB) group and non-GCB groups were 64.7％ and 62.4％,respectively (P=0.610).Univariated analysis revealed that the factors affecting OS of patients included age,lesion site,tumor size,gastrointestinal clinical Lugano staging system,IPI score (all P values ＜ 0.05).Multivariate Cox regression analysis revealed that IPI score was independent prognosis risk factor affecting OS (RR=3.609,95CI 2.034-6.404,P＜0.01).Conclusion IPI score was independent prognosis risk factor affecting OS of PGI-DLBCL patients.
