CAJ | 학술논문

糖尿病视网膜病变(DR)发病机制复杂,除了传统的4条致病分子通路外,统一机制、炎症反应、神经元退行性病变和血糖“代谢记忆”等多因素相互协同或拮抗以及上下游因子级联式的庞大网络是目前DR发病机制研究的热点.尽管如此,现有的这些研究或许也只是DR发生发展机制这座“冰山”的一角；DR机制研究仍然面临巨大的挑战.除考虑从多因素协同或上下游通路的关系角度加强对其新生血管生成等发病机制的研究外,多学科配合,探索DR与糖尿病其他全身疾病之间的联系,寻找新的关联靶点,或许会给DR基础研究带来新的收获.
당뇨병시망막병변(DR)발병궤제복잡,제료전통적4조치병분자통로외,통일궤제、염증반응、신경원퇴행성병변화혈당“대사기억”등다인소상호협동혹길항이급상하유인자급련식적방대망락시목전DR발병궤제연구적열점.진관여차,현유적저사연구혹허야지시DR발생발전궤제저좌“빙산”적일각；DR궤제연구잉연면림거대적도전.제고필종다인소협동혹상하유통로적관계각도가강대기신생혈관생성등발병궤제적연구외,다학과배합,탐색DR여당뇨병기타전신질병지간적련계,심조신적관련파점,혹허회급DR기출연구대래신적수획.
The pathogenesis of diabetic retinopathy is complicated.The vast network of multiple factors including unifying mechanism,inflammatory reaction,neuron degeneration and metabolic memory of glucose,and the four established pathogenic molecular pathways are hotspots of mechanism research for diabetic retinopathy.Nevertheless,these researches may be only one corner of the "iceberg" of DR mechanism,and we still face enormous challenges in DR mechanism research.Collaboration with multiple disciplines to study the relationship between DR and diabetes and other systemic diseases,search novel therapy targets may increase the result in an unexpected windfall for DR basic research.