中华眼科杂志
中華眼科雜誌
중화안과잡지
Chinese Journal of Ophthalmology
2012年
12期
1069-1072
,共4页
孔秀云%彭静婷%刘丽娟%颜榕%张晓君
孔秀雲%彭靜婷%劉麗娟%顏榕%張曉君
공수운%팽정정%류려연%안용%장효군
视神经炎%髓磷脂蛋白质类%自身抗体%视神经脊髓炎%多发性硬化%自身免疫疾病
視神經炎%髓燐脂蛋白質類%自身抗體%視神經脊髓炎%多髮性硬化%自身免疫疾病
시신경염%수린지단백질류%자신항체%시신경척수염%다발성경화%자신면역질병
Optic neuritis%Myelinproteins%Autoantibodies%Neuromyelitis optica%Multiple sclerosis%Autoimmune diseases
目的 初步探索抗髓鞘少突胶质细胞糖蛋白抗体(MOG-Ab)在不同临床类型免疫介导性视神经炎(IM-ON)患者血清中的表达.方法 采用临床病例横断面研究.2010年5月至2011年2月至北京同仁医院神经内科就诊的免疫介导性视神经炎患者(IM-ON) 129例,根据其临床特点分为以下5组:多发性硬化相关视神经炎(MS-ON) 20例,视神经脊髓炎相关视神经炎(NMO-ON) 13例,自身免疫病相关视神经炎(AON) 33例,复发性孤立性视神经炎(RION) 43例及单发性孤立性视神经炎(SION)20例.用ELISA方法对其血清中MOG-Ab进行检测,应用SPSS17.0软件,采用x2检验及方差分析、t检验方法对数据进行统计学分析,比较其阳性率与抗体滴度在不同组间的区别.结果 所有129例IM-ON患者中12例(9.3％)患者的血清MOG-Ab阳性.其中MS-ON组血清MOG-Ab阳性者5例(5/20),NMO-ON组0例(0/13),AON组4例(4/33),RION组2例(2/43),SION组1例(1/20).5组间阳性率差异无统计学意义(Fisher确切概率法,x2=7.051,P=0.088).将除MS-ON组之外的其余4组合并为“视神经脊髓炎(NMO)谱系视神经炎”后与MS-ON组比较发现,MS-ON组的MOG-Ab阳性率和抗体滴度均明显高于“NMO谱系视神经炎”组.结论 MOG抗体见于除NMO-ON之外的各种类型的IM-ON,在MS-ON患者血清中的表达明显高于“NMO谱系视神经炎”.
目的 初步探索抗髓鞘少突膠質細胞糖蛋白抗體(MOG-Ab)在不同臨床類型免疫介導性視神經炎(IM-ON)患者血清中的錶達.方法 採用臨床病例橫斷麵研究.2010年5月至2011年2月至北京同仁醫院神經內科就診的免疫介導性視神經炎患者(IM-ON) 129例,根據其臨床特點分為以下5組:多髮性硬化相關視神經炎(MS-ON) 20例,視神經脊髓炎相關視神經炎(NMO-ON) 13例,自身免疫病相關視神經炎(AON) 33例,複髮性孤立性視神經炎(RION) 43例及單髮性孤立性視神經炎(SION)20例.用ELISA方法對其血清中MOG-Ab進行檢測,應用SPSS17.0軟件,採用x2檢驗及方差分析、t檢驗方法對數據進行統計學分析,比較其暘性率與抗體滴度在不同組間的區彆.結果 所有129例IM-ON患者中12例(9.3％)患者的血清MOG-Ab暘性.其中MS-ON組血清MOG-Ab暘性者5例(5/20),NMO-ON組0例(0/13),AON組4例(4/33),RION組2例(2/43),SION組1例(1/20).5組間暘性率差異無統計學意義(Fisher確切概率法,x2=7.051,P=0.088).將除MS-ON組之外的其餘4組閤併為“視神經脊髓炎(NMO)譜繫視神經炎”後與MS-ON組比較髮現,MS-ON組的MOG-Ab暘性率和抗體滴度均明顯高于“NMO譜繫視神經炎”組.結論 MOG抗體見于除NMO-ON之外的各種類型的IM-ON,在MS-ON患者血清中的錶達明顯高于“NMO譜繫視神經炎”.
목적 초보탐색항수초소돌효질세포당단백항체(MOG-Ab)재불동림상류형면역개도성시신경염(IM-ON)환자혈청중적표체.방법 채용림상병례횡단면연구.2010년5월지2011년2월지북경동인의원신경내과취진적면역개도성시신경염환자(IM-ON) 129례,근거기림상특점분위이하5조:다발성경화상관시신경염(MS-ON) 20례,시신경척수염상관시신경염(NMO-ON) 13례,자신면역병상관시신경염(AON) 33례,복발성고립성시신경염(RION) 43례급단발성고립성시신경염(SION)20례.용ELISA방법대기혈청중MOG-Ab진행검측,응용SPSS17.0연건,채용x2검험급방차분석、t검험방법대수거진행통계학분석,비교기양성솔여항체적도재불동조간적구별.결과 소유129례IM-ON환자중12례(9.3％)환자적혈청MOG-Ab양성.기중MS-ON조혈청MOG-Ab양성자5례(5/20),NMO-ON조0례(0/13),AON조4례(4/33),RION조2례(2/43),SION조1례(1/20).5조간양성솔차이무통계학의의(Fisher학절개솔법,x2=7.051,P=0.088).장제MS-ON조지외적기여4조합병위“시신경척수염(NMO)보계시신경염”후여MS-ON조비교발현,MS-ON조적MOG-Ab양성솔화항체적도균명현고우“NMO보계시신경염”조.결론 MOG항체견우제NMO-ON지외적각충류형적IM-ON,재MS-ON환자혈청중적표체명현고우“NMO보계시신경염”.
Objective To investigate the expression of anti-myelin oligodendrocyte glycoprotein antibody (MOG-Ab) in different types of immune-mediated optic neuritis (IM-ON).Methods Case-control and cross section study.The serum of 129 consecutive cases of immune-mediated optic neuritis (IM-ON group) seen in Neuro-ophthalmology clinic in Department of Neurology,Beijing Tongren Hospital during May 2010 and February 2011 were collected.All IM-ON cases were further classified into five different types as:20 cases of multiple sclerosis related ON (MS-ON),13 cases of neuromyelitis optica related ON (NMO-ON),33 cases of autoimmune optic neuritis (AON),43 cases of relapsing isolated optic neuritis (RION)and 20 cases of solitary isolated optic neuritis (SION).MOG-Ab was tested by ELISA.The positivity rate and titer of MOG-Ab among these groups were compared using chi-square test and ANOVA,t test by SPSS17.0 software.Results MOG-Ab was positive in 12 of all 129 tested IM-ON patients (9.3％),in which there were 5 of 20 MS-ON,none of 13 NMO-ON,4 of 33 AON,2 of 43 RION,and 1 of 20 SION patients.There were no statistical significant difference among five groups (Fisher's exact test,x2 =7.051,P =0.088),but MS-ON group showed statistically higher MOG-Ab positivity and titer than the “ NMO spectrum optic neuritis” group which was merged from the other 4 IM-ON groups.Conclusion MOG-Ab could be detected in different types of immune-mediated optic neuritis except NMO-ON and the expression of MOG-Ab was statistically higher in MS-ON group than the 'NMO spectrum optic neuritis' group.
