中华眼科杂志
中華眼科雜誌
중화안과잡지
Chinese Journal of Ophthalmology
2013年
1期
41-46
,共6页
色觉缺陷%糖尿病并发症%色觉试验
色覺缺陷%糖尿病併髮癥%色覺試驗
색각결함%당뇨병병발증%색각시험
Color vision defects%Diabetes complications%Color perception tests
目的 观察糖尿病患者早期未出现糖尿病视网膜病变时的色觉改变.方法 回顾性系列病例研究.纳入78例(126只眼)经临床确诊的无并发视网膜病变的2型糖尿病患者(糖尿病组)和64例(114只眼)健康体检者(对照组)作为研究对象.采用Farnsworth Munsell-100型色觉测试仪逐眼检测受检者的辨色力,记录总错误得分(TES)及红、绿、蓝各色彩的错误得分(ES),以原值和平方根值表示.同时分析受检者年龄、病程、性别及胰岛素使用时间与色觉异常程度之间的关系.组间检测数据比较采用t检验、t'检验或u检验,色觉异常程度与受检者年龄、病程及胰岛素使用时间的关系采用Spearman秩相关分析法.色觉异常程度与性别的关系采用t检验(正态)或秩和检验(非正态).两组频数比较采用卡方检验,3组辨色力之间的比较采用Wilcoxon秩和检验.结果 糖尿病组和对照组TES分别为63.80±34.19和30.39±4.57,平方根值分别为7.69 ±2.17和5.50±0.42,两组差异均有统计学意义(TES比较:u=4.87,平方根值比较:u=4.91;P ＜0.05).糖尿病组红、绿、蓝3种色彩的ES分别为9.39±8.61、12.67±9.71、12.39±8.05,3种色彩的平方根值分别为2.62±1.60、3.23±1.51、3.28±1.27;对照组3种色彩的ES分别为5.13 ±3.59、7.00±1.84、6.81±2.70,3种色彩的平方根值分别为1.95±1.17、2.62±0.36、2.52 ±0.68;两组差异均有统计学意义(3种色彩的ES比较:u=3.62,4.94,5.40；3种色彩的平方根值比较:u=2.40,3.32,4.03；P＜0.05).两组3种辨色力差异有统计学意义(u =4.071,P＜0.05).除蓝色觉异常与受检者年龄相关(r=0.38,P＜0.05)外,红、绿、蓝3种色觉异常与糖尿病患者的性别(r=0.32 ～0.39)、病程(r=-0.02 ～0.23)及胰岛素使用时间(r=-0.03 ～0.11)均无关(P＞0.05).结论 糖尿病患者早期即出现色觉辨别力异常下降,色觉检测可以作为评价糖尿病患者早期色觉损害程度的重要手段.
目的 觀察糖尿病患者早期未齣現糖尿病視網膜病變時的色覺改變.方法 迴顧性繫列病例研究.納入78例(126隻眼)經臨床確診的無併髮視網膜病變的2型糖尿病患者(糖尿病組)和64例(114隻眼)健康體檢者(對照組)作為研究對象.採用Farnsworth Munsell-100型色覺測試儀逐眼檢測受檢者的辨色力,記錄總錯誤得分(TES)及紅、綠、藍各色綵的錯誤得分(ES),以原值和平方根值錶示.同時分析受檢者年齡、病程、性彆及胰島素使用時間與色覺異常程度之間的關繫.組間檢測數據比較採用t檢驗、t'檢驗或u檢驗,色覺異常程度與受檢者年齡、病程及胰島素使用時間的關繫採用Spearman秩相關分析法.色覺異常程度與性彆的關繫採用t檢驗(正態)或秩和檢驗(非正態).兩組頻數比較採用卡方檢驗,3組辨色力之間的比較採用Wilcoxon秩和檢驗.結果 糖尿病組和對照組TES分彆為63.80±34.19和30.39±4.57,平方根值分彆為7.69 ±2.17和5.50±0.42,兩組差異均有統計學意義(TES比較:u=4.87,平方根值比較:u=4.91;P ＜0.05).糖尿病組紅、綠、藍3種色綵的ES分彆為9.39±8.61、12.67±9.71、12.39±8.05,3種色綵的平方根值分彆為2.62±1.60、3.23±1.51、3.28±1.27;對照組3種色綵的ES分彆為5.13 ±3.59、7.00±1.84、6.81±2.70,3種色綵的平方根值分彆為1.95±1.17、2.62±0.36、2.52 ±0.68;兩組差異均有統計學意義(3種色綵的ES比較:u=3.62,4.94,5.40；3種色綵的平方根值比較:u=2.40,3.32,4.03；P＜0.05).兩組3種辨色力差異有統計學意義(u =4.071,P＜0.05).除藍色覺異常與受檢者年齡相關(r=0.38,P＜0.05)外,紅、綠、藍3種色覺異常與糖尿病患者的性彆(r=0.32 ～0.39)、病程(r=-0.02 ～0.23)及胰島素使用時間(r=-0.03 ～0.11)均無關(P＞0.05).結論 糖尿病患者早期即齣現色覺辨彆力異常下降,色覺檢測可以作為評價糖尿病患者早期色覺損害程度的重要手段.
목적 관찰당뇨병환자조기미출현당뇨병시망막병변시적색각개변.방법 회고성계렬병례연구.납입78례(126지안)경림상학진적무병발시망막병변적2형당뇨병환자(당뇨병조)화64례(114지안)건강체검자(대조조)작위연구대상.채용Farnsworth Munsell-100형색각측시의축안검측수검자적변색력,기록총착오득분(TES)급홍、록、람각색채적착오득분(ES),이원치화평방근치표시.동시분석수검자년령、병정、성별급이도소사용시간여색각이상정도지간적관계.조간검측수거비교채용t검험、t'검험혹u검험,색각이상정도여수검자년령、병정급이도소사용시간적관계채용Spearman질상관분석법.색각이상정도여성별적관계채용t검험(정태)혹질화검험(비정태).량조빈수비교채용잡방검험,3조변색력지간적비교채용Wilcoxon질화검험.결과 당뇨병조화대조조TES분별위63.80±34.19화30.39±4.57,평방근치분별위7.69 ±2.17화5.50±0.42,량조차이균유통계학의의(TES비교:u=4.87,평방근치비교:u=4.91;P ＜0.05).당뇨병조홍、록、람3충색채적ES분별위9.39±8.61、12.67±9.71、12.39±8.05,3충색채적평방근치분별위2.62±1.60、3.23±1.51、3.28±1.27;대조조3충색채적ES분별위5.13 ±3.59、7.00±1.84、6.81±2.70,3충색채적평방근치분별위1.95±1.17、2.62±0.36、2.52 ±0.68;량조차이균유통계학의의(3충색채적ES비교:u=3.62,4.94,5.40；3충색채적평방근치비교:u=2.40,3.32,4.03；P＜0.05).량조3충변색력차이유통계학의의(u =4.071,P＜0.05).제람색각이상여수검자년령상관(r=0.38,P＜0.05)외,홍、록、람3충색각이상여당뇨병환자적성별(r=0.32 ～0.39)、병정(r=-0.02 ～0.23)급이도소사용시간(r=-0.03 ～0.11)균무관(P＞0.05).결론 당뇨병환자조기즉출현색각변별력이상하강,색각검측가이작위평개당뇨병환자조기색각손해정도적중요수단.
Objective To detect the color discrimination changes in early-stage diabetic patients.Methods Retrospective series case study.A total of 78 type 2 diabetic patients (126 eyes) without diabetic retinopathy were enrolled.Another 64 healthy individuals were selected as the normal control.Total error scores (TES) and each error score (ES) in distinguishing the red,green and blue colors were measured via the Farnsworth-Munsell 100 hue tester.The TES origin scores and their square roots were used for statistical analysis.The results of the two groups were compared.The influence of gender,age,duration of diabetic mellitus and application time of insulin on TES and each color's ES values was investigated.The t,t' or u-test was adopted to compare the mean of TES and ES values between these two groups; the Spearman rank correlation analysis was used to analyze the relationship between TES and ES values and age,duration and duration of insulin usage; the t test was employed to analyze the relationship between TES and ES values vs.gender; the number of superior,average,low discrimination eyes were analyzed via the x2 test.Wilcoxon rank sum analysis was adopted in determining the color discrimination ability between these three groups.Results The TES and its square root values in the diabetic and normal groups were 63.80 ± 34.19,30.39 ±4.57 and 7.69 ± 2.17,5.50 ± 0.42,respectively.There were differences in both values between these two groups (t =4.87,4.91 ; P ＜ 0.05).The error scores and its square root values in distinguishing the red,green,blue colors in the diabetic group were 9.39 ±8.61,12.67 ±9.71,12.39 ±8.05 and 2.62 ± 1.60,3.23 ± 1.51,3.28 ± 1.27,respectively,and the values were 5.13 ±3.59,7.00 ±1.84,6.81 ±2.70 and 1.95 ± 1.17,2.62 ±0.36,2.52 ±0.68,respectively,in the normal group.There were differences between these two groups (u =3.62,4.94,5.40 and 2.40,3.32,4.03 ; P ＜ 0.05).Differences existed in discriminating the three colors between two groups (u =4.071,P ＜ 0.05).Except for age(r =0.38,P ＜ 0.05),there was no relationship between color vision defects and age,duration (r =-0.02 ～ 0.23,P ＞ 0.05),gender(r =0.32 ～ 0.39,P ＞ 0.05) or duration of insulin usage (r =-0.03 ～0.11,P ＞ 0.05).Conclusions Color vision defects appear in early-stage diabetic patients.Color discrimination can play an important role in the evaluation of color perception damage and visual function in diabetic patients.
