CAJ | 학술논문

退行性眼底病的病理特点主要体现在感光细胞的损伤及内层视网膜的结构异常.脑源性神经生长因子(BDNF)对其保护作用越来越受到关注.BDNF可以通过两种受体,即低亲和力的p75NTR和高亲和力的TrkB,以及视网膜生长锥丝状伪足及辅因子锌等发挥作用.它对于神经干细胞及视网膜祖细胞有诱导分化提高移植成功的作用,对多种视网膜神经细胞具有保护作用,亦可作用于其他眼组织细胞.在应用方面可对损伤变性的视神经有一定作用,并可与其他因子及药物联用.
퇴행성안저병적병리특점주요체현재감광세포적손상급내층시망막적결구이상.뇌원성신경생장인자(BDNF)대기보호작용월래월수도관주.BDNF가이통과량충수체,즉저친화력적p75NTR화고친화력적TrkB,이급시망막생장추사상위족급보인자자등발휘작용.타대우신경간세포급시망막조세포유유도분화제고이식성공적작용,대다충시망막신경세포구유보호작용,역가작용우기타안조직세포.재응용방면가대손상변성적시신경유일정작용,병가여기타인자급약물련용.
Degenerative fundus diseases are a group of outer retinal disease caused by dysfunction of photoreceptors,some of which have the inner layer defection.Brain-derived neurotrophic factor(BDNF) has been shown to play a key role in the neuronal survival,which accomplishes its protection via receptors,including a low affinity p75 and a high affinity tyrosine kinase receptor TrkB,retinal growth cone filopodia and cofactor of Zinc.It is proved that BDNF can induce differentiation of stem cells and retinal progenitor,in case for the effective retinal transplantion.The protection by BDNF has also been observed through the interaction with retinal neurons such as photoreceptors,bipolar cells,horizontal neurons,ganglion cells and dopaminergic cells,as well as other cells of eyes.Furthermore,BDNF has been used to attenuate the injuries of optic nerve and the application of BDNF combined with other neurotrophic factors and drugs also manifests a certain efficiency.