CAJ | 학술논문

葡萄膜炎是一类常见的致盲性眼病,其病因复杂、病程长、易反复,是眼科难治疾病之一.长期全身应用传统的治疗药物,如糖皮质激素和免疫抑制剂有较大的毒副作用.因此,寻找效果可靠、作用时间长的治疗方法成为必然.近年来,病毒载体介导的基因治疗在葡萄膜炎的研究中取得较大进展.目前主要通过两种方式达到治疗实验性葡萄膜炎的目的:一是利用病毒载体转导免疫调节分子,如白细胞介素(IL)-10、IL-1Ra、IL-4、IFN-α、IL-27p28在眼局部发挥免疫调节作用；二是通过载体导入与葡萄膜炎发生相关的抗原诱导免疫耐受.基因治疗葡萄膜炎有局部用药、长效和全身不良反应小的优势,可能会成为临床治疗葡萄膜炎的一种重要方法.
포도막염시일류상견적치맹성안병,기병인복잡、병정장、역반복,시안과난치질병지일.장기전신응용전통적치료약물,여당피질격소화면역억제제유교대적독부작용.인차,심조효과가고、작용시간장적치료방법성위필연.근년래,병독재체개도적기인치료재포도막염적연구중취득교대진전.목전주요통과량충방식체도치료실험성포도막염적목적:일시이용병독재체전도면역조절분자,여백세포개소(IL)-10、IL-1Ra、IL-4、IFN-α、IL-27p28재안국부발휘면역조절작용；이시통과재체도입여포도막염발생상관적항원유도면역내수.기인치료포도막염유국부용약、장효화전신불량반응소적우세,가능회성위림상치료포도막염적일충중요방법.
Uveitis is a group of common eye disease and is one of the major causes of blindness worldwide.Corticosteroids and immunosuppressive agents are commonly used for the treatment of uveitis.However,long-term application of these drugs frequently lead to numerous side effects.Recently,with the development of gene transfer techniques,viral vector mediated gene therapy has achieved remarkable success in experimental uveitis.Inhibition of ocular inflammation in animal models is obtained mainly by two ways:first,increase of the expression of different immune modulators including IL-10,IL-1Ra,IL-4 and IFN-alpha,or IL-27p28 ;secondly,induction of immune tolerance by transferring uveitis related antigens via viral vectors.Uveitis is characterized by long-lasting and recurrent,the unique properties of local administration,long-term effectiveness and minor side effects of gene therapy may provide a novel strategy for the treatment of the devastating uveitis.