中华眼科杂志
中華眼科雜誌
중화안과잡지
Chinese Journal of Ophthalmology
2013年
4期
340-344
,共5页
青光眼,闭角型%高眼压%氯前列醇%卡替洛尔
青光眼,閉角型%高眼壓%氯前列醇%卡替洛爾
청광안,폐각형%고안압%록전렬순%잡체락이
Glaucoma,angle-closure%Ocular hypertension%Cloprostenol%Carteolol
目的 比较0.004％曲伏前列素与2％卡替洛尔治疗原发性闭角型青光眼激光周边虹膜切除术(LPI)或小梁切除术后高眼压的临床效果.方法 对照研究.将原发性闭角型青光眼行LPI或小梁切除术后眼压＞21 mm Hg(1 mm Hg=0.133 kPa)的52例(52只眼)患者,分为曲伏前列素组和卡替洛尔组.分别给予0.004％曲伏前列素(每晚1次)或2％卡替洛尔(每天2次)眼液治疗.两组患者用药前后眼压、用药前后眼压差及用药后眼压下降百分率的比较均采用t检验；用药前后眼压差和用药后眼压下降百分率与前房角开放程度的关系采用Spearman相关分析法.结果 曲伏前列素组患者24例(24只眼),用药前眼压(24.67 ±3.08)mm Hg,用药后眼压(18.58±2.71) mm Hg,用药前后眼压差异有统计学意义(t=5.130,P＜0.05)；卡替洛尔组28例(28只眼),用药前眼压(23.57±1.60) mm Hg,用药后眼压(19.57±1.60)mm Hg,用药前后眼压差异有统计学意义(t=6.600,P＜0.05).两组患者间用药前后眼压差(t=2.533)和用药后眼压下降百分率(t=2.532)差异均有统计学意义(P＜0.05).两组患者的用药前后眼压差(r=0.145,0.090)和用药后眼压下降百分率(r =0.009,0.183)均与前房角开放程度无关(P＞0.05).结论 0.004％曲伏前列素和2％卡替洛尔对原发性闭角型青光眼术后高眼压均有降眼压效果,0.004％曲伏前列素的降眼压效果优于2％卡替洛尔.
目的 比較0.004％麯伏前列素與2％卡替洛爾治療原髮性閉角型青光眼激光週邊虹膜切除術(LPI)或小樑切除術後高眼壓的臨床效果.方法 對照研究.將原髮性閉角型青光眼行LPI或小樑切除術後眼壓＞21 mm Hg(1 mm Hg=0.133 kPa)的52例(52隻眼)患者,分為麯伏前列素組和卡替洛爾組.分彆給予0.004％麯伏前列素(每晚1次)或2％卡替洛爾(每天2次)眼液治療.兩組患者用藥前後眼壓、用藥前後眼壓差及用藥後眼壓下降百分率的比較均採用t檢驗；用藥前後眼壓差和用藥後眼壓下降百分率與前房角開放程度的關繫採用Spearman相關分析法.結果 麯伏前列素組患者24例(24隻眼),用藥前眼壓(24.67 ±3.08)mm Hg,用藥後眼壓(18.58±2.71) mm Hg,用藥前後眼壓差異有統計學意義(t=5.130,P＜0.05)；卡替洛爾組28例(28隻眼),用藥前眼壓(23.57±1.60) mm Hg,用藥後眼壓(19.57±1.60)mm Hg,用藥前後眼壓差異有統計學意義(t=6.600,P＜0.05).兩組患者間用藥前後眼壓差(t=2.533)和用藥後眼壓下降百分率(t=2.532)差異均有統計學意義(P＜0.05).兩組患者的用藥前後眼壓差(r=0.145,0.090)和用藥後眼壓下降百分率(r =0.009,0.183)均與前房角開放程度無關(P＞0.05).結論 0.004％麯伏前列素和2％卡替洛爾對原髮性閉角型青光眼術後高眼壓均有降眼壓效果,0.004％麯伏前列素的降眼壓效果優于2％卡替洛爾.
목적 비교0.004％곡복전렬소여2％잡체락이치료원발성폐각형청광안격광주변홍막절제술(LPI)혹소량절제술후고안압적림상효과.방법 대조연구.장원발성폐각형청광안행LPI혹소량절제술후안압＞21 mm Hg(1 mm Hg=0.133 kPa)적52례(52지안)환자,분위곡복전렬소조화잡체락이조.분별급여0.004％곡복전렬소(매만1차)혹2％잡체락이(매천2차)안액치료.량조환자용약전후안압、용약전후안압차급용약후안압하강백분솔적비교균채용t검험；용약전후안압차화용약후안압하강백분솔여전방각개방정도적관계채용Spearman상관분석법.결과 곡복전렬소조환자24례(24지안),용약전안압(24.67 ±3.08)mm Hg,용약후안압(18.58±2.71) mm Hg,용약전후안압차이유통계학의의(t=5.130,P＜0.05)；잡체락이조28례(28지안),용약전안압(23.57±1.60) mm Hg,용약후안압(19.57±1.60)mm Hg,용약전후안압차이유통계학의의(t=6.600,P＜0.05).량조환자간용약전후안압차(t=2.533)화용약후안압하강백분솔(t=2.532)차이균유통계학의의(P＜0.05).량조환자적용약전후안압차(r=0.145,0.090)화용약후안압하강백분솔(r =0.009,0.183)균여전방각개방정도무관(P＞0.05).결론 0.004％곡복전렬소화2％잡체락이대원발성폐각형청광안술후고안압균유강안압효과,0.004％곡복전렬소적강안압효과우우2％잡체락이.
Objective To compare the intraocular pressure (IOP) lowering effect of 0.004％ travoprost and 2％ carteolol in patients with ocular hypertension (OHT) after laser peripheral iridotomy (LPI) or trabeculectomy in primary angle-closure glaucoma (PACG).Methods Clinical case control trial.52 consecutive PACG patients (52 eyes) with IOP ＞ 21 mm Hg(1 mm Hg =0.133 kPa)after LPI or trabeculectomy were enrolled.24 patients received topical application of 0.004％ travoprost (once daily)and 28 received 2％ carteolol(twice daily).IOP lowering effect of travoprost and carteolol before and after treatment was measured by Goldmann tonometer and compared using t-test.The relationship of IOP lowering effect and the degree of angle open was performed by gonioscope and analyzed using Spearman rank correlation.Results Compared with pre-treatment,the IOP was significantly reduced in 24 patients (24 eyes) in 0.004％ travoprost group [pre-treatment:(24.67 ± 3.08) mm Hg,post-treatment:(18.58 ±2.71) mm Hg ;t =6.600,P ＜ 0.05],while significantly reduced in 28 patients (28 eyes) received 2％carteolol [pre-treatment:(23.57 ± 1.60) mm Hg,post-treatment:(19.57 ± 1.60) mm Hg; t =5.130,P ＜0.05].0.004％ travoprost group is more significant in both quantity and percentage of IOP lowering than 2％ carteolol(t =2.533,2.532 ;P ＜ 0.05).There was no correlation between the IOP lowering effect and the degree of angle open in both groups (0.004％ travoprost r =0.145,0.009;P ＞0.05; 2％ carteolol r =0.090,0.183,P ＞ 0.05).Conclusions Both of 0.004％ travoprost and 2％ carteolol reduce IOP in patients with OHT after LPI or trabeculectomy in PACG.0.004％ travoprost is more effective than 2％carteolol in IOP lowering.However,the decrease of IOP is not acted through the alteration of anterior chamber angle in both study groups.
