中华眼科杂志
中華眼科雜誌
중화안과잡지
Chinese Journal of Ophthalmology
2014年
3期
179-183
,共5页
杨梅%朱蓉嵘%梁从凯%刘必红%戚应祥%张俊芳%施健%管怀进
楊梅%硃蓉嶸%樑從凱%劉必紅%慼應祥%張俊芳%施健%管懷進
양매%주용영%량종개%류필홍%척응상%장준방%시건%관부진
白内障%危险因素%年龄因素%性别因素%吸烟
白內障%危險因素%年齡因素%性彆因素%吸煙
백내장%위험인소%년령인소%성별인소%흡연
Cataract%Risk factors%Age factors%Sex factors%Smoking
目的 探讨江苏省阜宁县社区50岁及以上人群发生白内障的相关因素.方法 病例对照研究.收集江苏省阜宁县眼病研究数据库中l 488例白内障确诊患者作为病例组,1 821例双眼无视力损伤人群为对照组,两组人群的调查时间均为2010年6月至2011年5月.通过单因素及多因素logistic回归分析病例组与对照组在人群特征、生活行为习惯、既往病史、既往阳光照射时间等方面的差异.结果 单因素分析结果显示,随着年龄增长,白内障发生风险升高,以50 ～＜ 60岁为参考组、60～＜70岁、70 ～＜ 80岁、≥80岁发生白内障的优势比(OR)分别是6.88(P ＜0.01)、87.66(P＜0.0l)、416.19(P＜0.01);女性风险高于男性(OR=1.24,P=0.003);与文盲组相比,小学、初中、高中及以上人群白内障的发生风险逐渐减少(OR=0.44、0.42、0.09,P值均＜0.01);农民、既往吸烟、高血压及糖尿病人群白内障发生率均高于非农民、不吸烟、非高血压以及非糖尿病人群(OR=3.13,P＜0.01;OR=1.23,P=0.003;OR=1.44,P＜0.01;OR=1.92,P＜0.01);与既往每日阳光照射时间＜3h相比,阳光照射时间3～＜4h、4～＜6h、≥6h组发生白内障的风险增加(OR=2.09、2.89、6.52,P值均＜0.01);未发现婚姻状况、饮酒等因素与白内障患病有相关性(P＞0.05).多因素非条件logistic回归分析结果显示,白内障的危险因素为高龄[与50～ ＜60岁相比,60～ ＜70岁、70～＜ 80岁、≥80岁受检人群发生白内障的风险增加(OR=6.83、132.39、868.68,P值均＜0.01)]、女性(OR =2.29,P＜0.01)、既往阳光照射时间长[与＜3h组相比,3～＜4h、4～＜6h、≥6 h组发生白内障的风险增加(OR =2.88、5.99、13.28,P值均＜0.01)]、既往吸烟(OR=1.87,P=0.019)及患有糖尿病(OR=l.31,P=0.029),而受教育程度高为保护因素[与文盲组相比,小学、初中、高中及以上受检人群发生白内障的风险减小(OR =0.64、0.41、0.31,P值均＜0.01)].结论 高龄、女性、吸烟、糖尿病及既往阳光照射时间长是江苏省阜宁县社区50岁及以上人群白内障发生的危险因素,受教育程度高是其保护因素.
目的 探討江囌省阜寧縣社區50歲及以上人群髮生白內障的相關因素.方法 病例對照研究.收集江囌省阜寧縣眼病研究數據庫中l 488例白內障確診患者作為病例組,1 821例雙眼無視力損傷人群為對照組,兩組人群的調查時間均為2010年6月至2011年5月.通過單因素及多因素logistic迴歸分析病例組與對照組在人群特徵、生活行為習慣、既往病史、既往暘光照射時間等方麵的差異.結果 單因素分析結果顯示,隨著年齡增長,白內障髮生風險升高,以50 ～＜ 60歲為參攷組、60～＜70歲、70 ～＜ 80歲、≥80歲髮生白內障的優勢比(OR)分彆是6.88(P ＜0.01)、87.66(P＜0.0l)、416.19(P＜0.01);女性風險高于男性(OR=1.24,P=0.003);與文盲組相比,小學、初中、高中及以上人群白內障的髮生風險逐漸減少(OR=0.44、0.42、0.09,P值均＜0.01);農民、既往吸煙、高血壓及糖尿病人群白內障髮生率均高于非農民、不吸煙、非高血壓以及非糖尿病人群(OR=3.13,P＜0.01;OR=1.23,P=0.003;OR=1.44,P＜0.01;OR=1.92,P＜0.01);與既往每日暘光照射時間＜3h相比,暘光照射時間3～＜4h、4～＜6h、≥6h組髮生白內障的風險增加(OR=2.09、2.89、6.52,P值均＜0.01);未髮現婚姻狀況、飲酒等因素與白內障患病有相關性(P＞0.05).多因素非條件logistic迴歸分析結果顯示,白內障的危險因素為高齡[與50～ ＜60歲相比,60～ ＜70歲、70～＜ 80歲、≥80歲受檢人群髮生白內障的風險增加(OR=6.83、132.39、868.68,P值均＜0.01)]、女性(OR =2.29,P＜0.01)、既往暘光照射時間長[與＜3h組相比,3～＜4h、4～＜6h、≥6 h組髮生白內障的風險增加(OR =2.88、5.99、13.28,P值均＜0.01)]、既往吸煙(OR=1.87,P=0.019)及患有糖尿病(OR=l.31,P=0.029),而受教育程度高為保護因素[與文盲組相比,小學、初中、高中及以上受檢人群髮生白內障的風險減小(OR =0.64、0.41、0.31,P值均＜0.01)].結論 高齡、女性、吸煙、糖尿病及既往暘光照射時間長是江囌省阜寧縣社區50歲及以上人群白內障髮生的危險因素,受教育程度高是其保護因素.
목적 탐토강소성부저현사구50세급이상인군발생백내장적상관인소.방법 병례대조연구.수집강소성부저현안병연구수거고중l 488례백내장학진환자작위병례조,1 821례쌍안무시력손상인군위대조조,량조인군적조사시간균위2010년6월지2011년5월.통과단인소급다인소logistic회귀분석병례조여대조조재인군특정、생활행위습관、기왕병사、기왕양광조사시간등방면적차이.결과 단인소분석결과현시,수착년령증장,백내장발생풍험승고,이50 ～＜ 60세위삼고조、60～＜70세、70 ～＜ 80세、≥80세발생백내장적우세비(OR)분별시6.88(P ＜0.01)、87.66(P＜0.0l)、416.19(P＜0.01);녀성풍험고우남성(OR=1.24,P=0.003);여문맹조상비,소학、초중、고중급이상인군백내장적발생풍험축점감소(OR=0.44、0.42、0.09,P치균＜0.01);농민、기왕흡연、고혈압급당뇨병인군백내장발생솔균고우비농민、불흡연、비고혈압이급비당뇨병인군(OR=3.13,P＜0.01;OR=1.23,P=0.003;OR=1.44,P＜0.01;OR=1.92,P＜0.01);여기왕매일양광조사시간＜3h상비,양광조사시간3～＜4h、4～＜6h、≥6h조발생백내장적풍험증가(OR=2.09、2.89、6.52,P치균＜0.01);미발현혼인상황、음주등인소여백내장환병유상관성(P＞0.05).다인소비조건logistic회귀분석결과현시,백내장적위험인소위고령[여50～ ＜60세상비,60～ ＜70세、70～＜ 80세、≥80세수검인군발생백내장적풍험증가(OR=6.83、132.39、868.68,P치균＜0.01)]、녀성(OR =2.29,P＜0.01)、기왕양광조사시간장[여＜3h조상비,3～＜4h、4～＜6h、≥6 h조발생백내장적풍험증가(OR =2.88、5.99、13.28,P치균＜0.01)]、기왕흡연(OR=1.87,P=0.019)급환유당뇨병(OR=l.31,P=0.029),이수교육정도고위보호인소[여문맹조상비,소학、초중、고중급이상수검인군발생백내장적풍험감소(OR =0.64、0.41、0.31,P치균＜0.01)].결론 고령、녀성、흡연、당뇨병급기왕양광조사시간장시강소성부저현사구50세급이상인군백내장발생적위험인소,수교육정도고시기보호인소.
Objective To investigate the risk factors of cataract among people aged 50 years and above in Funing county of Jiangsu province.Methods Case-control study.All of 1 488 cataract cases were selected from cataract patients' database and 1 821 subjects without visual impairment were recruited as controls from Funing county who were examined between June 2010 and May 2011.Unconditional logistic regression was used to analyze possible risk factors of cataract such as socioeconomic status,lifestyles,history of chronic disease,and history of exposure to sunlight.Results The univariate analysis results showed that the risk of cataract on-set was higher with aging.Odds ratios (ORs) for people aged 60 to ＜70 years,70 to ＜ 80 years,and ≥80 years were 6.88,87.66,and 416.19 respectively with statistical significance comparing to people aged 60 years and below.Female had 12％ higher risk of getting cataract than male(OR =1.24,P =0.003).Compared with the illiterate,the ORs with educational background of elementary school,junior high school,and high school and above were 0.44 (P ＜ 0.01),0.42 (P ＜ 0.01) and 0.09 (P ＜ 0.01) respectively.The risk of cataract in farmers,smokers,people with high blood pressureor diabetes were significantly high with OR of 3.13 (P ＜ 0.01),1.23 (P =0.003),1.44 and 1.92 (P ＜ 0.01),respectively.Long time exposure to sunlight increased cataract risk.The ORs of sunlight exposure during 3 to ＜4 hours,4 to ＜ 6 hours and ≥ 6 hours were 2.09 (P ＜ 0.01),2.89 (P ＜ 0.01),and 6.52 (P ＜ 0.01) respectively comparing to exposure less than 3 hours per day.Marital status and alcohol drinking were not associated with cataract (P ＞ 0.05).Multiple logistic regression analysis showed that the risk factors of cataract were the age (comparing the age of 50 to ＜60 years,the OR values of 60 to ＜70 years,70 to ＜80 years and ≥80years were 6.83,132.39,868.68 respectively with P ＜ 0.01),the gender(OR =2.29 for females,P ＜0.01),sunlight exposure(the OR for 3 to ＜ 4 hours exposure,4 to ＜ 6 hours exposure and ≥6 hours exposure were 2.88,5.99 and 13.28 respectively comparing to people with less than 3 hour exposure per day),smoking(OR =1.87,P =0.019) and diabetes(OR =1.31,P =0.029).Education was a protective factor with OR of 0.64,0.41 and 0.31 (P ＜ 0.01) for elementary school,junior high school and high school respectively.Conclusion Senior people,female,low level of education,smoking,history of diabetes and long time exposure to sunlight are risk factors of cataract among elderly people aged 50 years and above in Funing country.
