中华眼科杂志
中華眼科雜誌
중화안과잡지
Chinese Journal of Ophthalmology
2014年
4期
303-306
,共4页
黄彩虹%陈文生%陈永雄%刘祖国
黃綵虹%陳文生%陳永雄%劉祖國
황채홍%진문생%진영웅%류조국
苯扎胺化合物%眼药水%防腐剂,药物%眼表现
苯扎胺化閤物%眼藥水%防腐劑,藥物%眼錶現
분찰알화합물%안약수%방부제,약물%안표현
Benzalkonium compounds%Ophthalmic solutions%Preservatives,pharmaceutical%Eye manifestations
苯扎氯铵是滴眼液中最常用的防腐剂.至今有大量临床及实验研究表明,使用含苯扎氯铵的滴眼液会引起包括细胞凋亡在内的一系列眼表损伤.但最近有临床研究表明眼表正常的患者使用含苯扎氯铵的滴眼液后引起的眼表毒性与苯扎氯铵并无明显联系.有学者认为研究本身的局限性导致了人们对苯扎氯铵的毒性认识存在夸大之嫌.在此,我们总结了近年来有关苯扎氯铵临床及实验研究的众多资料,将对苯扎氯铵的眼表毒性研究现状作一综述.
苯扎氯銨是滴眼液中最常用的防腐劑.至今有大量臨床及實驗研究錶明,使用含苯扎氯銨的滴眼液會引起包括細胞凋亡在內的一繫列眼錶損傷.但最近有臨床研究錶明眼錶正常的患者使用含苯扎氯銨的滴眼液後引起的眼錶毒性與苯扎氯銨併無明顯聯繫.有學者認為研究本身的跼限性導緻瞭人們對苯扎氯銨的毒性認識存在誇大之嫌.在此,我們總結瞭近年來有關苯扎氯銨臨床及實驗研究的衆多資料,將對苯扎氯銨的眼錶毒性研究現狀作一綜述.
분찰록안시적안액중최상용적방부제.지금유대량림상급실험연구표명,사용함분찰록안적적안액회인기포괄세포조망재내적일계렬안표손상.단최근유림상연구표명안표정상적환자사용함분찰록안적적안액후인기적안표독성여분찰록안병무명현련계.유학자인위연구본신적국한성도치료인문대분찰록안적독성인식존재과대지혐.재차,아문총결료근년래유관분찰록안림상급실험연구적음다자료,장대분찰록안적안표독성연구현상작일종술.
Benzalkonium chloride (BAC) is the most commonly used preservative in ophthalmic preparations.So far large bodies of clinical and experimental studies have shown that use of topical drugs containing BAC can induce a series of ocular surface diseases,such as apoptosis.However,recently,some clinical studies have shown that ocular toxicity in patients treated with eye drops containing BAC has not apparent correlated with BAC.Some scholars consider that the limitations of the research lead people to recognize the BAC toxicity exaggeratedly.Here we summarize numerous clinical and experimental studies of BAC in the past few years,and focus on reviewing recent researches of the toxic effect of BAC on ocular surfface.