CAJ | 학술논문

目的评价单眼弱视人群双眼黄斑厚度差异,为应用OCT探讨弱视发病机制及指导弱视诊断提供线索.方法 Meta分析.检索万方、PubMed等中英文数据库并通过Google Scholar搜索引擎进行文献补充,对有关单眼弱视对象双眼黄斑区OCT检查的临床研究进行筛选、评估和数据提取,将弱视患者双眼黄斑中心凹最小厚度、黄斑中心凹1 mm直径区域厚度纳入研究.应用RevMan5.02软件进行Meta分析.结果应用时域OCT的研究纳入4篇文献,纳入对象均为屈光参差性弱视患者,黄斑中心凹最小厚度仅纳入1项研究,弱视眼比对侧眼厚(P =0.045);Meta分析结果提示弱视眼黄斑中心凹1 mm直径区域比对侧眼厚6.82 μm(P＜0.05,95％可信区间为2.81～10.83).应用频域OCT的研究纳入5篇文献,Meta分析结果提示弱视眼与对侧眼黄斑中心凹最小厚度差异及各亚组差异无统计学意义(P=0.50);弱视眼黄斑中心凹1 mm直径区域厚度高于对侧眼7.38 μm(P＜0.05,95％可信区间为3.13 ～11.63),亚组分析提示屈光参差性弱视亚组弱视眼高于对侧眼而斜视性弱视亚组双眼差异无统计学意义.结论单眼弱视患者弱视眼黄斑中心区域厚度高于对侧非弱视眼,提示弱视患者黄斑厚度研究可以为弱视发病的外周机制提供佐证.
목적 평개단안약시인군쌍안황반후도차이,위응용OCT탐토약시발병궤제급지도약시진단제공선색.방법 Meta분석.검색만방、PubMed등중영문수거고병통과Google Scholar수색인경진행문헌보충,대유관단안약시대상쌍안황반구OCT검사적림상연구진행사선、평고화수거제취,장약시환자쌍안황반중심요최소후도、황반중심요1 mm직경구역후도납입연구.응용RevMan5.02연건진행Meta분석.결과 응용시역OCT적연구납입4편문헌,납입대상균위굴광삼차성약시환자,황반중심요최소후도부납입1항연구,약시안비대측안후(P =0.045);Meta분석결과제시약시안황반중심요1 mm직경구역비대측안후6.82 μm(P＜0.05,95％가신구간위2.81～10.83).응용빈역OCT적연구납입5편문헌,Meta분석결과제시약시안여대측안황반중심요최소후도차이급각아조차이무통계학의의(P=0.50);약시안황반중심요1 mm직경구역후도고우대측안7.38 μm(P＜0.05,95％가신구간위3.13 ～11.63),아조분석제시굴광삼차성약시아조약시안고우대측안이사시성약시아조쌍안차이무통계학의의.결론 단안약시환자약시안황반중심구역후도고우대측비약시안,제시약시환자황반후도연구가이위약시발병적외주궤제제공좌증.
Objective To offer a clue for the etiology of amblyopia by systematically comparing the macular thickness measured by optical coherence tomography (OCT) between the amblyopic eye and the fellow normal eye in patients with unilateral amblyopia.Methods Databases including Wanfang,PubMed and others were searched,and data were extracted after quality assessment,then the Meta analysis was preformed by the RevMan 5.02 software.Results Four studies using the time-domain OCT (TD-OCT) were enrolled in the analysis and all those were anisometropic amblyopic patients.The only one study showed that the foveal minimum thickness is thicker in the amblyopic eyes than the fellow ones (P =0.045).The meta analysis indicated the amblyopic eyes were 6.82 μm (P ＜ 0.05,95％ CI:2.81-10.83) thicker in the fovea (1 mm diameter region).Five trials using the spectral-domain OCT (SD-OCT) were included in the analysis.It showed no significant difference in the foveal minimum thickness between amblyopic and fellow eyes.Also,no significant difference were detected in either anisometropic or strabismic subgroup (P =0.50).Amblyopic eyes were 7.38 μm thicker in the fovea (1 mm diameter region) (P ＜0.05,95％ CI:3.13-11.63)and significant difference in the anisometropic subgroup while no significant difference in the strabismic subgroup were detected.Conclusions The macular fovea is thicker in the amblyopic eyes than the fellow ones by the use of OCT,so it is effective to measure the macular thickness of amblyopia in searching evidence for the etiology of amblyopia.