CAJ | 학술논문

目的探讨眼动脉、视网膜中央动脉和睫状动脉血流参数变化与原发性视网膜色素变性(RP)的相关性.方法回顾性系列病例研究.应用彩色多普勒血管显像检测184例(92只左眼,92只右眼)临床诊断为RP的患者.测定眼动脉、视网膜中央动脉及睫状动脉的收缩期峰速(PSV),舒张末期流速(EDV),时间平均最大流速(TAMV),脉动指数(PI)和阻力指数(RI).所得定量数据采用单样本t检验,行RP组与以往文献中健康人(对照组)的各项参数进行比较.结果 RP患者眼动脉PSV、EDV、TAMV分别为(33.05±8.62)、(7.74±3.04)、(14.16±4.43) cm/s,与对照组[(31.47±9.63)、(7.11±2.34)、(12.44±3.64) cm/s]相比均明显升高,差异有统计学意义.但患者PI(1.87 ±0.73)较对照组(2.02±0.71)相比明显降低,差异有统计学意义(t=-2.794,P＜0.05).RP患者视网膜中央动脉的PSV、EDV、TAMV、PI和RI分别为[(5.30±1.36)、(2.11±0.49)、(3.01 ±0.680) cm/s]、[(1.05±0.28)、(0.60±0.18)],与对照组[(10.82±2.97)、(3.28±1.11)、(5.50±2.06) cm/s]和[(1.48±0.49)、(0.71±0.08)]相比均明显降低,差异有统计学意义(t=-55.186、-32.015、-49.634、-20.430、-8.704;P ＜0.05).RP患者睫状动脉的PSV、EDV、TAMV、PI和RI分别为[(7.60±1.95)、(2.59±0.58)、(4.07±1.00) cm/s]和[(1.23±0.28)、(0.65±0.80)],与对照组[(11.61±3.41)、(3.34±1.25)、(5.83±1.91) cm/s]和[(1.49±0.43)、(0.70±0.09)]相比均明显降低,差异有统计学意义(t=-28.097、-17.541、-23.842、12.445、-8.720;P＜0.05).结论 RP患者眼动脉、视网膜中央动脉和睫状动脉血流参数异常提示眼部的血液供应和RP病理过程存在相关性.
목적 탐토안동맥、시망막중앙동맥화첩상동맥혈류삼수변화여원발성시망막색소변성(RP)적상관성.방법 회고성계렬병례연구.응용채색다보륵혈관현상검측184례(92지좌안,92지우안)림상진단위RP적환자.측정안동맥、시망막중앙동맥급첩상동맥적수축기봉속(PSV),서장말기류속(EDV),시간평균최대류속(TAMV),맥동지수(PI)화조력지수(RI).소득정량수거채용단양본t검험,행RP조여이왕문헌중건강인(대조조)적각항삼수진행비교.결과 RP환자안동맥PSV、EDV、TAMV분별위(33.05±8.62)、(7.74±3.04)、(14.16±4.43) cm/s,여대조조[(31.47±9.63)、(7.11±2.34)、(12.44±3.64) cm/s]상비균명현승고,차이유통계학의의.단환자PI(1.87 ±0.73)교대조조(2.02±0.71)상비명현강저,차이유통계학의의(t=-2.794,P＜0.05).RP환자시망막중앙동맥적PSV、EDV、TAMV、PI화RI분별위[(5.30±1.36)、(2.11±0.49)、(3.01 ±0.680) cm/s]、[(1.05±0.28)、(0.60±0.18)],여대조조[(10.82±2.97)、(3.28±1.11)、(5.50±2.06) cm/s]화[(1.48±0.49)、(0.71±0.08)]상비균명현강저,차이유통계학의의(t=-55.186、-32.015、-49.634、-20.430、-8.704;P ＜0.05).RP환자첩상동맥적PSV、EDV、TAMV、PI화RI분별위[(7.60±1.95)、(2.59±0.58)、(4.07±1.00) cm/s]화[(1.23±0.28)、(0.65±0.80)],여대조조[(11.61±3.41)、(3.34±1.25)、(5.83±1.91) cm/s]화[(1.49±0.43)、(0.70±0.09)]상비균명현강저,차이유통계학의의(t=-28.097、-17.541、-23.842、12.445、-8.720;P＜0.05).결론 RP환자안동맥、시망막중앙동맥화첩상동맥혈류삼수이상제시안부적혈액공응화RP병리과정존재상관성.
Objective To study changes of blood flow of ophthalmic artery (OA),central retinal artery (CRA) and posterior ciliary artery (PCA) in patients with primary retinitis pigmentosa.Methods Color Doppler flow imaging (CDIF) was used in 184 cases (184 eyes) of RP patient.The peak systolic velocity (PSV),end diastolic velocity (EDV),time-averaged maximum velocity (TAMV),pulsatility index (PI) and resistance index (RI) were measured in OA,CRA and PCA separately.Data was analyzed statistically by One-Sample T Test to compare changes of these parameters between RP and normal group.Results Concerning RP group,inOA,thePSV,EDV,TAMV[(33.05±8.62),(7.74±3.04),(14.16± 4.43) cm/s] vs normal group[(31.47±9.63),(7.11 ±2.34),(12.44 ±3.64) cm/s] were increased,the differences were statistically significant (t =-2.481,2.820,5.253,P ＜ 0.05).But the PI in OA of RP (1.87 ± 0.73) vs normal group (2.02 ± 0.71) was deceased,the difference was statistically significant (t =-2.794 ;P ＜ 0.05).Concerning RP group,in CRA,the PSV,EDV,TAMV,PI and RI [(5.30 ± 1.36),(2.11 ±0.49),(3.01 ±0.680) cm/s],[(1.05 ±0.28),(0.60 ±0.18)] vs normal group [(10.82 ± 2.97),(3.28 ±1.11),(5.50±2.06) cm/s],[(1.48 ±0.49),(0.71 ±0.08)] were decreased,the differences were statistically significant (t =-55.186,-32.015,-49.634,-20.430,-8.704,P ＜ 0.05).Concerning RP group,in PCA,the PSV 、EDV 、TAMV 、PI and RI [(7.60 ± 1.95),(2.59 ± 0.58),(4.07±1.00) cm/s],[(1.23 ±0.28),(0.65±0.80)] vs normal group[(11.61 ±3.41),(3.34± 1.25),(5.83 ± 1.91) cm/s],[(1.49 ± 0.43),(0.70 ± 0.09)] were decreased,the differences were statistically significant (t =-28.097,-17.541,-23.842,12.445,-8.720,P ＜ 0.05).Conclusions Hemodynamic abnormal changes of OA,RCA and PCA in RP patients possibly suggest the role of blood supply in occurrence or development of RP.Maintaining normal ocular blood flow may be able to offer a new way for prevention and treatment for RP.