CAJ | 학술논문

禽流感病毒已经导致多起人类禽流感的暴发,给人类带来重大的灾难.2013年在我国流行的H7N9禽流感,重新唤起了我们对人感染禽流感的重视.越来越多的证据表明,眼是禽流感病毒感染人类的入侵途径之一,导致结膜炎.目前研究表明,只有禽流感病毒H7和H5亚型可以导致系统的严重感染,禽流感病毒的入侵可能与结膜和角膜上α-2,3唾液酸糖苷受体较为丰富有关;另外,H7亚型能特异激活NF-κB信号转导通路也与其眼嗜性相关.这些研究提示,对于临床医师而言,在流感流行季节诊断结膜炎过程中要注重与禽流感病毒感染的鉴别;对于疾控人员在处置禽流感疫情时,需要加强眼睛的防护.本文就禽流感病毒结膜炎的流行及其眼嗜性的分子基础做一综述.
금류감병독이경도치다기인류금류감적폭발,급인류대래중대적재난.2013년재아국류행적H7N9금류감,중신환기료아문대인감염금류감적중시.월래월다적증거표명,안시금류감병독감염인류적입침도경지일,도치결막염.목전연구표명,지유금류감병독H7화H5아형가이도치계통적엄중감염,금류감병독적입침가능여결막화각막상α-2,3타액산당감수체교위봉부유관;령외,H7아형능특이격활NF-κB신호전도통로야여기안기성상관.저사연구제시,대우림상의사이언,재류감류행계절진단결막염과정중요주중여금류감병독감염적감별;대우질공인원재처치금류감역정시,수요가강안정적방호.본문취금류감병독결막염적류행급기안기성적분자기출주일종술.
Avian influenza virus (AIV) has caused several outbreaks in humans,leading to disasters to human beings.The outbreak of H7N9 avian influenza in China in 2003 re-attracted our close attention to this disease.More and more evidences demonstrated that eye is one of invasion portals of AIV,leading to conjunctivitis.The current studies showed that only subtypes H7 and H5 could cause severe systemic infections.Abundant distribution of α-2,3 siliac acid receptor in conjunctiva and cornea as well as specific activiation of NF-κB signal transduction pathway by subtype H7 virus may contribute to the ocular tropism of the virus.These studies suggest that avian influenza conjunctivitis should be considered as a differential diagnosis during influenza epidemic seasons,and eyes should be well protected for disease control personnel when handling avian influenza epidemics.This review focused on AIV conjunctivitis and the molecular basis of ocular tropism.