CAJ | 학술논문

糖尿病视网膜病变是临床上常见的眼部疾病之一.增殖性糖尿病视网膜病的病理特点之一是视网膜新生血管的产生,是目前影响糖尿病患者视力的主要原因.随着抗VEGF的药物的推广,该类药物已经成为治疗糖尿病视网膜病的主要药物.但是因为其局限性,研究者们继续探索针对抗新生血管的其他新的药物靶点,以期联合用药或个体化治疗.目前研究主要集中于促血管生成因子,整联蛋白、基质蛋白激酶,以及针对血管形成过程中的典型细胞尖端细胞和柄细胞分化、增殖的药物.总之,这些研究揭开我们抗新生血管的新视野,本文旨在探讨目前可能的抗新生血管的药物靶点,归纳了抗血管药物研究中的关键问题.
당뇨병시망막병변시림상상상견적안부질병지일.증식성당뇨병시망막병적병리특점지일시시망막신생혈관적산생,시목전영향당뇨병환자시력적주요원인.수착항VEGF적약물적추엄,해류약물이경성위치료당뇨병시망막병적주요약물.단시인위기국한성,연구자문계속탐색침대항신생혈관적기타신적약물파점,이기연합용약혹개체화치료.목전연구주요집중우촉혈관생성인자,정련단백、기질단백격매,이급침대혈관형성과정중적전형세포첨단세포화병세포분화、증식적약물.총지,저사연구게개아문항신생혈관적신시야,본문지재탐토목전가능적항신생혈관적약물파점,귀납료항혈관약물연구중적관건문제.
Diabetic retinopathy is one of the common ocular diseases.One of the pathological characteristic of proliferative diabetic retinopathy is retinal neovascularization which caused visual impairment in diabetic patients.With the anti-VEGF drugs applying in the clinic,it has become one of the main medical treatment of diabetic retinopathy.But it has its limitation.Researchers continue to explore new drug targeting for anti-angiogenesis and try combination therapy or customized treatment.There are many drug targets for anti-angiogenesis,such as promoting angiogenesis factor,integrins and matrix proteinases.Some drugs act on the typical tip cells which is much important in the process of angiogenesis differentiation and proliferation.Overall,these studies opened our view of anti-angiogenesis.The purpose of this article is to summarize the possible drug targets of angiogenesis and the key issues in the study of anti-angiogenic drugs.