中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2013年
12期
910-915
,共6页
梅静静%梁瀛%沈宁%贺蓓
梅靜靜%樑瀛%瀋寧%賀蓓
매정정%량영%침저%하배
白细胞介素1%多态性,单核苷酸%肺疾病,慢性阻塞性%Meta分析
白細胞介素1%多態性,單覈苷痠%肺疾病,慢性阻塞性%Meta分析
백세포개소1%다태성,단핵감산%폐질병,만성조새성%Meta분석
Interleukin-1%Polymorphism,single nucleotide%Pulmonary disease,chronic obstructive%Meta-analysis
目的 评价白细胞介素1B(IL-1B)基因的-511C/T、-31T/C、+3954C/T基因多态性与慢性阻塞性肺疾病发病(COPD)的相关性.方法 全面检索PubMed、Embase、Ovid数据库、万方数据库及中国期刊全文数据库获取IL-1B基因多态性与COPD易感性的病例-对照研究,采用等位基因位点、显性遗传模型、隐性遗传模型、共显性遗传模型分别评价COPD发病的相对危险度,并通过人种分组、对各基因多态性进行亚组分析.运用荟萃分析方法综合评价IL-1B基因的-511C/T、-31T/C、+3954C/T基因多态性与COPD的相关性.结果 共有7篇病例-对照研究文献被纳入,荟萃分析结果显示-511C/T、-31T/C、+3954 C/T基因多态性与COPD均无显著相关性,但以人种分组的亚组分析显示:-511C/T的T等位基因在高加索人中与COPD显著相关(OR=1.76,95％ CI为1.22～2.54,P=0.002),但在亚洲人中无相关性(OR=0.94,95％ CI为0.64～1.38,P=0.736).-31T/C的C等位基因在高加索人中与COPD显著相关(OR=0.62,95％ CI为0.40 ～0.97,P=0.035),但在亚洲人中无相关性(OR=1.06,95％ CI为0.89～ 1.26,P=0.533).结论 IL-1B基因多态性与COPD的易感性有人种差异；在高加索人中,IL-1B-511C/T的T等位基因与COPD发病风险呈正相关,IL-1B-31T/C的C等位基因与COPD发病风险呈负相关.
目的 評價白細胞介素1B(IL-1B)基因的-511C/T、-31T/C、+3954C/T基因多態性與慢性阻塞性肺疾病髮病(COPD)的相關性.方法 全麵檢索PubMed、Embase、Ovid數據庫、萬方數據庫及中國期刊全文數據庫穫取IL-1B基因多態性與COPD易感性的病例-對照研究,採用等位基因位點、顯性遺傳模型、隱性遺傳模型、共顯性遺傳模型分彆評價COPD髮病的相對危險度,併通過人種分組、對各基因多態性進行亞組分析.運用薈萃分析方法綜閤評價IL-1B基因的-511C/T、-31T/C、+3954C/T基因多態性與COPD的相關性.結果 共有7篇病例-對照研究文獻被納入,薈萃分析結果顯示-511C/T、-31T/C、+3954 C/T基因多態性與COPD均無顯著相關性,但以人種分組的亞組分析顯示:-511C/T的T等位基因在高加索人中與COPD顯著相關(OR=1.76,95％ CI為1.22～2.54,P=0.002),但在亞洲人中無相關性(OR=0.94,95％ CI為0.64～1.38,P=0.736).-31T/C的C等位基因在高加索人中與COPD顯著相關(OR=0.62,95％ CI為0.40 ～0.97,P=0.035),但在亞洲人中無相關性(OR=1.06,95％ CI為0.89～ 1.26,P=0.533).結論 IL-1B基因多態性與COPD的易感性有人種差異；在高加索人中,IL-1B-511C/T的T等位基因與COPD髮病風險呈正相關,IL-1B-31T/C的C等位基因與COPD髮病風險呈負相關.
목적 평개백세포개소1B(IL-1B)기인적-511C/T、-31T/C、+3954C/T기인다태성여만성조새성폐질병발병(COPD)적상관성.방법 전면검색PubMed、Embase、Ovid수거고、만방수거고급중국기간전문수거고획취IL-1B기인다태성여COPD역감성적병례-대조연구,채용등위기인위점、현성유전모형、은성유전모형、공현성유전모형분별평개COPD발병적상대위험도,병통과인충분조、대각기인다태성진행아조분석.운용회췌분석방법종합평개IL-1B기인적-511C/T、-31T/C、+3954C/T기인다태성여COPD적상관성.결과 공유7편병례-대조연구문헌피납입,회췌분석결과현시-511C/T、-31T/C、+3954 C/T기인다태성여COPD균무현저상관성,단이인충분조적아조분석현시:-511C/T적T등위기인재고가색인중여COPD현저상관(OR=1.76,95％ CI위1.22～2.54,P=0.002),단재아주인중무상관성(OR=0.94,95％ CI위0.64～1.38,P=0.736).-31T/C적C등위기인재고가색인중여COPD현저상관(OR=0.62,95％ CI위0.40 ～0.97,P=0.035),단재아주인중무상관성(OR=1.06,95％ CI위0.89～ 1.26,P=0.533).결론 IL-1B기인다태성여COPD적역감성유인충차이；재고가색인중,IL-1B-511C/T적T등위기인여COPD발병풍험정정상관,IL-1B-31T/C적C등위기인여COPD발병풍험정부상관.
Objective To explore the association between the-511C/T,-31T/C and +3954C/T polymorphisms of interleukin-1B (IL-1 B) gene and chronic obstructive pulmonary disease (COPD) using the method of meta-analysis.Methods Comprehensive searches were performed of PubMed,Embase,Ovid,Wanfang and Chinese journal full-text database to retrieve the related case-control studies.The pooled odds ratios were performed respectively for allele comparison,additive genetic model,dominant genetic model and recessive genetic model and subgroup analysis was also performed by ethnicity.Results Seven case-control studies were included for meta-analysis.Pooled analysis showed that neither-511C/T,-31T/C nor + 3954 C/T polymorphisms increased the susceptibility to COPD.In the subgroup analysis by ethnicity,significant risks were found in the Caucasian population for-511C/T T allele (OR =1.76,95％CI 1.22-2.54,P =0.002),but not in the Asian population(OR =0.94,95％ CI 0.64-1.38,P =0.736).Significant risks were also found in the Caucasian population for-31T/C C allele (OR =0.62,95％ CI 0.40-0.97,P =0.035),but not in the Asian population (OR =1.06,95％ CI 0.89-1.26,P =0.533).Conclusions IL-1B polymorphisms may play a role in the susceptibility of COPD in an ethnicityspecific manner.In the Caucasian population,the risk of COPD was associated positively with the IL-1B -511C/T T allele and negatively with the IL-1B-31T/C C allele.
