CAJ | 학술논문

目的探讨2型糖尿病患者颈动脉僵硬度变化规律及其与内中膜厚度(IMT)的关系.方法 2009年5月7至30日,北京大学第一医院内分泌科共72例2型糖尿病患者纳入研究,所有患者行颈动脉超声检查,应用射频信号血管内中膜分析技术(QIMT)软件描记颈动脉IMT,动脉僵硬度测量技术(QAS)软件测量颈动脉顺应性系数(CC)、僵硬度系数(α)、血管直径归一化硬度系数(β)、脉搏波传播速度(PWV)等参数.患者控制血糖、血脂、血压水平达到正常标准.于2011年2月再次行超声检查,测量以上参数.对以上数据进行分析.结果与2009年超声检查比较,2011年超声检查双侧颈动脉CC明显升高(左侧0.9±0.4比1.1±0.4,P=0.016；右侧1.1±0.5比1.2±0.5,P=0.012).双侧颈动脉IMT有升高趋势,α、β、PWV有降低趋势,但差异无统计学意义.同一时间点分析糖尿病患者颈动脉IMT与动脉僵硬度参数无相关性.结论控制血糖、血脂、血压能降低2型糖尿病患者颈动脉僵硬度.2型糖尿病患者颈动脉IMT与动脉僵硬度参数没有相关性.
목적 탐토2형당뇨병환자경동맥강경도변화규률급기여내중막후도(IMT)적관계.방법 2009년5월7지30일,북경대학제일의원내분비과공72례2형당뇨병환자납입연구,소유환자행경동맥초성검사,응용사빈신호혈관내중막분석기술(QIMT)연건묘기경동맥IMT,동맥강경도측량기술(QAS)연건측량경동맥순응성계수(CC)、강경도계수(α)、혈관직경귀일화경도계수(β)、맥박파전파속도(PWV)등삼수.환자공제혈당、혈지、혈압수평체도정상표준.우2011년2월재차행초성검사,측량이상삼수.대이상수거진행분석.결과 여2009년초성검사비교,2011년초성검사쌍측경동맥CC명현승고(좌측0.9±0.4비1.1±0.4,P=0.016；우측1.1±0.5비1.2±0.5,P=0.012).쌍측경동맥IMT유승고추세,α、β、PWV유강저추세,단차이무통계학의의.동일시간점분석당뇨병환자경동맥IMT여동맥강경도삼수무상관성.결론 공제혈당、혈지、혈압능강저2형당뇨병환자경동맥강경도.2형당뇨병환자경동맥IMT여동맥강경도삼수몰유상관성.
Objective To explore the change pattern of carotid stiffness and its relationship between intima-media thickness (IMT) in type 2 diabetes mellitus (T2DM).Methods Quantitative intima-media thickness (QIMT) and quantitative arterial stiffness (QAS) were performed on bilateral carotids of 72 T2DM patients in May 2009 and February 2011 separately.IMT,compliance coefficent (CC),α,β and pulse wave velocity (PWV) were measured.Their relationship was analyzed.Results Comparing with ultrasound result in 2009,CC of bilateral carotids increased (left 0.9 ± 0.4 vs 1.1 ± 0.4,p =0.016 ; right 1.1 ± 0.5 vs 1.2±0.5,P =0.012).IMT increased while α,β and PWV decreased (P ＞0.05) in 2011.No correlation existed between carotid IMT and QAS parameters.Conclusion The glycemic,lipid and blood pressure controls decrease the carotid stiffness of patients with T2DM.Carotid IMT and stiffness