CAJ | 학술논문

目的分析27例直肠原发胃肠间质瘤(GIST)的临床特点,探讨影响预后的因素.方法回顾性分析2000年1月至2011年12月间中国医学科学院肿瘤医院腹部外科收治并经手术治疗的27例直肠胃肠间质瘤的临床资料,并进行预后分析.结果 27例患者临床多以排便习惯改变或便血发病(19/27),病变多位于直肠下段(21/27),中位直径5 cm(0.7 ～8.0 cm).中位随访时间为54个月(9 ～ 152个月).总体1、3、5年无进展生存率(PFS)为85.19％、65.04％和52.04％.单因素分析显示,总生存率和无疾病进展生存率与切缘以及是否存在周围器官侵犯显著相关,而与手术方式无明显关系.因病例数限制,无法进行有效的多因素分析.结论切缘和周围其他器官侵犯是影响预后的重要因素；对于符合手术指征的患者,局部切除是一种安全、有效的治疗方式.
목적 분석27례직장원발위장간질류(GIST)적림상특점,탐토영향예후적인소.방법 회고성분석2000년1월지2011년12월간중국의학과학원종류의원복부외과수치병경수술치료적27례직장위장간질류적림상자료,병진행예후분석.결과 27례환자림상다이배편습관개변혹편혈발병(19/27),병변다위우직장하단(21/27),중위직경5 cm(0.7 ～8.0 cm).중위수방시간위54개월(9 ～ 152개월).총체1、3、5년무진전생존솔(PFS)위85.19％、65.04％화52.04％.단인소분석현시,총생존솔화무질병진전생존솔여절연이급시부존재주위기관침범현저상관,이여수술방식무명현관계.인병례수한제,무법진행유효적다인소분석.결론 절연화주위기타기관침범시영향예후적중요인소；대우부합수술지정적환자,국부절제시일충안전、유효적치료방식.
Objective To explore the clinicopathological characteristics of rectal gastrointestinal stromal tumors (GISTs) and elucidate their associated prognostic factors.Methods The clinicopathological data were collected for 27 patients with rectal gastrointestinal stromal tumors at our hospital from January 2000 to December 2011.Univariate analyses were performed to evaluate the prognostic factors.Results Changed habit of discharge and hematochezia were the most common symptoms.Most GISTs were localized in lower rectum.The 1,3 and 5-year progression-free survival (PFS) rates were 85.19％,65.04％ and 52.04％ respectively.Overall survival (OS) and PFS rates were significantly correlated with incisional margin and invasion of surrounding organs.There was no significant difference in PFS and OS between different resection procedures.Due to the limitation of cases multivariate survival analysis can not be pertormed.Conclusion Incisional margin and invasion of surrounding organs are two important prognostic factors.And transanal excision is both safe and effective for those properly indicated patients.