CAJ | 학술논문

目的探讨18氟-氟代脱氧葡萄糖(18 F-FDG) PET/CTA成像检测兔主动脉易损斑块和预测血栓事件可行性.方法 28只雄性新西兰大白兔,高脂饲料饲喂2周后球囊拉伤腹主动脉,继续间断高脂饲养14周后进行药物诱发实验,以期斑块破裂和形成血栓；在药物诱发实验前后分别行主动脉的PET/CTA成像,分段测量主动脉对FDG的摄取情况(SUV值),成像后处死动物获得主动脉段的大体病理和组织学资料.将PET/CTA成像所得数据与组织病理学资料进行统计学分析.结果实验中有8只兔死亡,存活的20只兔中有13只(65％)产生血栓,将有无血栓动脉段在诱发实验前的SUVmean及SUVmax值进行比较,结果未形成血栓动脉段显著低于有血栓形成动脉段(0.77 ±0.11比1.10±0.19,P=0.000)及(0.80±0.12比1.23±0.29,P=0.000)；将诱发实验后的SUVmean及SUVmax值进行比较,结果未形成血栓动脉段亦显著低于有血栓形成动脉段(0.85±0.17比1.15±0.26,P=0.000)及(0.91±0.19比1.29±0.31,P=0.000).通过受试者工作特征(ROC)曲线评价SUVmean值对动脉段内血栓形成的预测价值.结果显示ROC曲线下面积为0.898(95％ CI0.857～0.939),P=0.000,截断值为0.882.结论 18F-FDP PET/CTA这一无创技术可以用于检测易损斑块,并在一定程度上预测斑块破裂和血栓形成的风险.
목적 탐토18불-불대탈양포도당(18 F-FDG) PET/CTA성상검측토주동맥역손반괴화예측혈전사건가행성.방법 28지웅성신서란대백토,고지사료사위2주후구낭랍상복주동맥,계속간단고지사양14주후진행약물유발실험,이기반괴파렬화형성혈전；재약물유발실험전후분별행주동맥적PET/CTA성상,분단측량주동맥대FDG적섭취정황(SUV치),성상후처사동물획득주동맥단적대체병리화조직학자료.장PET/CTA성상소득수거여조직병이학자료진행통계학분석.결과 실험중유8지토사망,존활적20지토중유13지(65％)산생혈전,장유무혈전동맥단재유발실험전적SUVmean급SUVmax치진행비교,결과미형성혈전동맥단현저저우유혈전형성동맥단(0.77 ±0.11비1.10±0.19,P=0.000)급(0.80±0.12비1.23±0.29,P=0.000)；장유발실험후적SUVmean급SUVmax치진행비교,결과미형성혈전동맥단역현저저우유혈전형성동맥단(0.85±0.17비1.15±0.26,P=0.000)급(0.91±0.19비1.29±0.31,P=0.000).통과수시자공작특정(ROC)곡선평개SUVmean치대동맥단내혈전형성적예측개치.결과 현시ROC곡선하면적위0.898(95％ CI0.857～0.939),P=0.000,절단치위0.882.결론 18F-FDP PET/CTA저일무창기술가이용우검측역손반괴,병재일정정도상예측반괴파렬화혈전형성적풍험.
Objective To investigate the feasibility of identifying the vulnerable plaque and predicting plague rupture and thrombus using by positron emission tomography/computed tomography angiography (PET/CTA).Methods Twenty-eight male New Zealand white rabbits were fed with hyperlipid diet for 2 weeks before the balloon injury of the abdominal aorta.Then these rabbit were intermittently fed withhyper-lipid diet for 14 weeks,in order to trigger pharmaceuticly the plague rupture and thrombus.PET/CTA scans of abdominal aorta were performed before and after the drug triggering,FDG uptake (standardized uptake value,SUV) was measured.Rabbits were euthanized to obtain data of pathology and histology.The parameters obtained by PET/CTA,pathology and histology were compared and the correclations were performed.Results The thrombosis was identified in 13 of 20 rabbits.Before the drug triggering,18F-FDG mean standardized uptake value(SUVmean) washigher in thrombotic arterial segments (defined as vulnerable plaque) (1.10 ± 0.19 vs 0.77 ± 0.11,P =0.000) ; after the drug triggering,SUVmean was higher in thrombotic arterial segments,too (1.15 ±0.26 vs 0.85 ±0.17,P =0.000).We use the ROC curve for SUVmean to predict plaque rupture and thrombosis.The areaunder the curve (AUC) was 0.898 (P =0.000).The cutoff value was 0.882.Conclusions Our findings indicated that 1s F-FDG PET/CTA,as a noninvasive imaging method,could be used toidentify vulnerable plaques and predict thrombosis events.