CAJ | 학술논문

目的探讨代谢综合征(MS)与颅内动脉粥样硬化性多支病变的相关性.方法选取2009年4月至2010年10月南京军区南京总医院神经内科有症状性颅内动脉粥样硬化性连续住院患者139例,借助磁共振血管成像和(或)CT血管成像和(或)全脑血管造影明确颅内动脉粥样硬化情况,按病变支数分为单支病变组和多支病变组；采用ATPⅢ修订版的MS诊断标准,明确两组MS的发生率；分析影响多支病变的危险因素,并探讨MS与颅内动脉粥样硬化性多支病变的相关性.结果 139例症状性颅内动脉粥样硬化患者共发现210支颅内动脉病变,其中59例(42.4％)有2支或以上病变.所有患者MS发生率为70.5％,其中单支病变组和多支病变组分别为56.3％和89.8％(P＜0.001).颅内病变支数随着MS组分个数增加而递增(P ＜0.001).另外,分析MS组分后发现仅高血糖与多支病变关系密切(P =0.002).Logistic回归多因素分析显示MS与颅内动脉多支病变有关(e=0.006).结论 MS是颅内动脉粥样硬化性多支病变的独立预测因素,积极干预MS或许可以预防颅内动脉粥样硬化性多支病变的发生.
목적 탐토대사종합정(MS)여로내동맥죽양경화성다지병변적상관성.방법 선취2009년4월지2010년10월남경군구남경총의원신경내과유증상성로내동맥죽양경화성련속주원환자139례,차조자공진혈관성상화(혹)CT혈관성상화(혹)전뇌혈관조영명학로내동맥죽양경화정황,안병변지수분위단지병변조화다지병변조；채용ATPⅢ수정판적MS진단표준,명학량조MS적발생솔；분석영향다지병변적위험인소,병탐토MS여로내동맥죽양경화성다지병변적상관성.결과 139례증상성로내동맥죽양경화환자공발현210지로내동맥병변,기중59례(42.4％)유2지혹이상병변.소유환자MS발생솔위70.5％,기중단지병변조화다지병변조분별위56.3％화89.8％(P＜0.001).로내병변지수수착MS조분개수증가이체증(P ＜0.001).령외,분석MS조분후발현부고혈당여다지병변관계밀절(P =0.002).Logistic회귀다인소분석현시MS여로내동맥다지병변유관(e=0.006).결론 MS시로내동맥죽양경화성다지병변적독립예측인소,적겁간예MS혹허가이예방로내동맥죽양경화성다지병변적발생.
Objective To explore the effects of metabolic syndrome (MS) on multi-vessel lesions of symptomatic intracranial atherosclerosis.Methods During April 2009 and October 2010,a total of 139 consecutive hospitalized patients with symptomatic intracranial atherosclerosis were recruited to undergo magnetic resonance angiography (MRA) or/and CT angiography (CTA) or/and digital subtraction angiography (DSA) to measure the stenotic degree and numbers of intracranial atherosclerosis.They were divided into 2 groups according to lesion numbers:single and multi-vessel lesions.MS was defined by the criteria of the Adult Treatment Panel Ⅲ to examine the incidences of MS.The risk factors were analyzed for multi-vessel lesions of symptomatic intracranial atherosclerosis to explore the relationship between MS and multi-vessel lesions.Results Among them,210 intracranial atherosclerotic lesions were documented.Fifty-nine (42.4％) patients had two or more lesions (group with multi-vessel lesions).The incidence of MS was 70.5％.The rates of MS in groups of single and multi-vessel lesions were 56.3％ and 89.8％ respectively.And statistical significance existed between two groups (P ＜0.001).Moreover,the number of MS components increased gradually with the number of lesions (P ＜ 0.001).For the analysis of individual criteria for MS,only abnormal glycemia was found to be associated with multi-vessel lesions (P =0.002).And multiple Logistic regression analysis showed that MS was associated with multi-vessel lesions ofintracranial atherosclerosis (P =O.001).Conclusions MS is an independent predictor for multi-vessel lesions of intracranial atherosclerosis.And its intervention may be an important preventive strategy for intracranial multi-vessel atherosclerosis.