中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2013年
24期
1894-1896
,共3页
罗耀凌%徐培光%彭颂国%李健沛%邝妙欢
囉耀凌%徐培光%彭頌國%李健沛%鄺妙歡
라요릉%서배광%팽송국%리건패%광묘환
C反应蛋白质%肿瘤%败血症%高荧光强度淋巴细胞百分比%降钙素原
C反應蛋白質%腫瘤%敗血癥%高熒光彊度淋巴細胞百分比%降鈣素原
C반응단백질%종류%패혈증%고형광강도림파세포백분비%강개소원
C-reactive protein%Neoplasms%Septicemia%Percentage of highly fluorescent lymphocytic cells%Procalcitonin
目的 评价高荧光强度淋巴细胞百分比(HFLC％)快速诊断肿瘤患者败血症的价值.方法 选取2011年3月至2012年11月中山大学肿瘤防治中心住院并进行血培养的肿瘤患者130例(败血症者60例,非败血症者70例),血培养的同时全自动血液细胞分析仪检测患者外周血HFLC％,胶乳免疫比浊法和快速半定量免疫色谱法测定C反应蛋白(CRP)和降钙素原(PCT)水平,以80名健康体检者作为对照组,比较各组间差异及指标间的相关性.应用受试者工作特征(ROC)曲线评价HFLC％和CRP诊断败血症的效能.结果 败血症组外周血HFLC％和CRP水平均明显高于非败血症组和健康对照组[0.30％ (0.10％ ～0.70％)比0.10％(0～0.20％)、0.10％ (0 ～0.20％),80.3(28.5 ～129.5)比3.3(1.4～41.4)、1.4(0.6 ～2.5)mg/L,均P＜0.01].HFLC％和CRP诊断败血症曲线下面积分别为0.72和0.92,敏感度为71.7％和96.7％,特异度为58.7％和82.0％,两者判断败血症效能均较好.败血症组HFLC％水平与PCT和CRP呈显著正相关(r=0.637、0.241,均P＜0.01).结论 HFLC％可作为辅助诊断肿瘤患者败血症简便、快速、经济的新指标,有利于及早判断败血症和避免不必要的抗生素应用.
目的 評價高熒光彊度淋巴細胞百分比(HFLC％)快速診斷腫瘤患者敗血癥的價值.方法 選取2011年3月至2012年11月中山大學腫瘤防治中心住院併進行血培養的腫瘤患者130例(敗血癥者60例,非敗血癥者70例),血培養的同時全自動血液細胞分析儀檢測患者外週血HFLC％,膠乳免疫比濁法和快速半定量免疫色譜法測定C反應蛋白(CRP)和降鈣素原(PCT)水平,以80名健康體檢者作為對照組,比較各組間差異及指標間的相關性.應用受試者工作特徵(ROC)麯線評價HFLC％和CRP診斷敗血癥的效能.結果 敗血癥組外週血HFLC％和CRP水平均明顯高于非敗血癥組和健康對照組[0.30％ (0.10％ ～0.70％)比0.10％(0～0.20％)、0.10％ (0 ～0.20％),80.3(28.5 ～129.5)比3.3(1.4～41.4)、1.4(0.6 ～2.5)mg/L,均P＜0.01].HFLC％和CRP診斷敗血癥麯線下麵積分彆為0.72和0.92,敏感度為71.7％和96.7％,特異度為58.7％和82.0％,兩者判斷敗血癥效能均較好.敗血癥組HFLC％水平與PCT和CRP呈顯著正相關(r=0.637、0.241,均P＜0.01).結論 HFLC％可作為輔助診斷腫瘤患者敗血癥簡便、快速、經濟的新指標,有利于及早判斷敗血癥和避免不必要的抗生素應用.
목적 평개고형광강도림파세포백분비(HFLC％)쾌속진단종류환자패혈증적개치.방법 선취2011년3월지2012년11월중산대학종류방치중심주원병진행혈배양적종류환자130례(패혈증자60례,비패혈증자70례),혈배양적동시전자동혈액세포분석의검측환자외주혈HFLC％,효유면역비탁법화쾌속반정량면역색보법측정C반응단백(CRP)화강개소원(PCT)수평,이80명건강체검자작위대조조,비교각조간차이급지표간적상관성.응용수시자공작특정(ROC)곡선평개HFLC％화CRP진단패혈증적효능.결과 패혈증조외주혈HFLC％화CRP수평균명현고우비패혈증조화건강대조조[0.30％ (0.10％ ～0.70％)비0.10％(0～0.20％)、0.10％ (0 ～0.20％),80.3(28.5 ～129.5)비3.3(1.4～41.4)、1.4(0.6 ～2.5)mg/L,균P＜0.01].HFLC％화CRP진단패혈증곡선하면적분별위0.72화0.92,민감도위71.7％화96.7％,특이도위58.7％화82.0％,량자판단패혈증효능균교호.패혈증조HFLC％수평여PCT화CRP정현저정상관(r=0.637、0.241,균P＜0.01).결론 HFLC％가작위보조진단종류환자패혈증간편、쾌속、경제적신지표,유리우급조판단패혈증화피면불필요적항생소응용.
Objective To evaluate the value of percentage of highly fluorescent lymphocytic cells (HFLC％) for rapidly assessing septicemia in tumor patients.Methods Blood samples were collected from 130 patients with tumors (60 septicemia patients and 70 non-septicemia patients)and 80 healthy controls.HFLC％ was analyzed with Sysmex XE-5000,the level of C-reactive protein (CRP) measured with a commercially available turbidimetric immunoassay kit and the level of procalcitonin (PCT) determined with a semiquantitative chromato-graphic immunoassay kit.The diagnostic values of HFLC％ and CRP in septicemia were evaluated with ROC analysis.Results The values of HFLC％ and CRP were significantly higher in the septicemia group than those in the non-septicemia and healthy groups (0.30％ (0.10％-0.70％)vs 0.10％(0-0.20％),0.10％ (0-0.20％); 80.3(28.5-129.5) vs 3.3(1.4-41.4),1.4 (0.6-2.5) mg/L,all P ＜ 0.01).The ROC-AUCs for HFLC％ and CRP for a diagnosis of septicemia were 0.72 (sensitivity 71.7％,specificity 58.7％) and 0.92 (sensitivity 96.7％,specificity 82.0％).Both of them could judge septicemia better.Additionally,HFLC％ was correlated with the levels of PCT and CRP (r =0.637,0.241,both P ＜ 0.01).Conclusions HFLC％ may be used as a rapid and simple auxiliary indicator in the diagnosis of septicemia in patients with tumors.And it is conducive to make an early diagnosis of septicemia and avoid unnecessary use of antibiotics.
