CAJ | 학술논문

目的研究血清铁蛋白(SF)与全身型幼年特发性关节炎(SOJIA)疾病活动性是否相关,能否根据SF在SOJIA病程中的变化初步判断疾病活动性及预后.方法选取2005年9月至2012年12月北京儿童医院风湿免疫科SOJIA患儿92例,其中合并巨噬细胞活化综合征(MAS)25例,多关节型幼年特发性关节炎(JIA)33例,少关节型JIA 30例.同时选取健康儿童47名及急性感染性疾病患儿30例分别作为正常对照组和感染对照组.用化学发光法分别对所有对象血样本进行SF检测.JIA各组及感染组同时检测白细胞、血红蛋白、血小板、C反应蛋白及红细胞沉降率.SOJIA缓解期复查上述指标.将结果进行统计学分析.结果活动期SOJIA患儿SF水平(555±2037) g/L,明显高于正常对照组、感染对照组及其他类型JIA,均P＜0.01;缓解期SF明显下降.并发MAS的SOJIA患儿SF水平为(12 707 ±6789) μg/L,显著高于未并发MAS的活动期SOJIA,差异有统计学意义.结论 SF水平与SOJIA活动性相关,对疾病活动性及预后判断有重要指导意义.
목적 연구혈청철단백(SF)여전신형유년특발성관절염(SOJIA)질병활동성시부상관,능부근거SF재SOJIA병정중적변화초보판단질병활동성급예후.방법 선취2005년9월지2012년12월북경인동의원풍습면역과SOJIA환인92례,기중합병거서세포활화종합정(MAS)25례,다관절형유년특발성관절염(JIA)33례,소관절형JIA 30례.동시선취건강인동47명급급성감염성질병환인30례분별작위정상대조조화감염대조조.용화학발광법분별대소유대상혈양본진행SF검측.JIA각조급감염조동시검측백세포、혈홍단백、혈소판、C반응단백급홍세포침강솔.SOJIA완해기복사상술지표.장결과진행통계학분석.결과 활동기SOJIA환인SF수평(555±2037) g/L,명현고우정상대조조、감염대조조급기타류형JIA,균P＜0.01;완해기SF명현하강.병발MAS적SOJIA환인SF수평위(12 707 ±6789) μg/L,현저고우미병발MAS적활동기SOJIA,차이유통계학의의.결론 SF수평여SOJIA활동성상관,대질병활동성급예후판단유중요지도의의.
Objective To explore the correlation of serum ferritin (SF) and systemic onset juvenile idiopathic arthritis (SOJIA) so as to determine the prognostic values of SF for SOJIA.Methods All samples were collected from 92 juvenile idiopathic arthritis (JIA) patients at Beijing Children's Hospital between February 2005 to September 2012.Their age range was 2-15 years.There were maerophage activation syndrome (MAS,n =25),polyartieular JIA (n =33) and oligoartieular JIA (n =30).And 47 healthy children and another 30 with acute infective diseases were selected as control groups respectively.Blood samples were collected and SF was measured in different disease phases.Other parameters include leucocyte,hemoglobin,platelet,C-reactive protein and erythrocyte sedimentation rate.Statistics of SF level at different groups as well as at different disease phases were performed.Results The SF level of active phase SOJIA patients was significantly higher (P ＜ 0.01) than that in Other groups.And its level in the active phase of SOJIA was significantly higher than that in patients during the recovery phase.The SF level in patients with MAS was significantly higher than that in those without MAS.Conclusion Correlated with the course of SOJIA,the level of SF may judge the disease activity and predict the outcomes of SOJIA.