CAJ | 학술논문

目的观察醋酸甲地孕酮(甲地孕酮乙酸盐)硅阴道环的避孕效果和安全性.方法纳入165例健康育龄期女性志愿者使用醋酸甲地孕酮硅阴道环避孕12个月,分析避孕有效性、安全性及满意度等.结果随访12个月累积妊娠率为3.93％,停用率2.54％,不良事件发生率为11.52％(19例),不良反应1.81％(3例),症状均较轻微,不需要治疗；使用中阴道环脱落率18.2％(27例).出血模式和正常月经周期相似；使用前后血生化指标均在正常范围内,甘油三酯上升、低密度脂蛋白下降,差异均有统计学意义,其他化验指标(如高密度脂蛋白、胆固醇等)差异均无统计学意义;阴道环使用12个月后的受试者满意度为94.6％,随着使用时间的延长满意度逐渐提高.结论醋酸甲地孕酮硅阴道环临床使用安全、有效,可能成为避孕新选择.
목적 관찰작산갑지잉동(갑지잉동을산염)규음도배적피잉효과화안전성.방법 납입165례건강육령기녀성지원자사용작산갑지잉동규음도배피잉12개월,분석피잉유효성、안전성급만의도등.결과 수방12개월루적임신솔위3.93％,정용솔2.54％,불량사건발생솔위11.52％(19례),불량반응1.81％(3례),증상균교경미,불수요치료；사용중음도배탈락솔18.2％(27례).출혈모식화정상월경주기상사；사용전후혈생화지표균재정상범위내,감유삼지상승、저밀도지단백하강,차이균유통계학의의,기타화험지표(여고밀도지단백、담고순등)차이균무통계학의의;음도배사용12개월후적수시자만의도위94.6％,수착사용시간적연장만의도축점제고.결론 작산갑지잉동규음도배림상사용안전、유효,가능성위피잉신선택.
Objective To explore the efficacy and safety of megestrol acetate silicone vaginal ring.Methods A total of 165 healthy child-bearing age women were recruited to examine the efficacy,safety and satisfaction rate of megestrol acetate silicone vaginal ring.Results The cumulative pregnancy rate of megestrol acetate silicone vaginal ring was 3.93％.And its discontinuation rate was 2.54％,the incidence of adverse events 11.52％ and the incidence of adverse effects 1.81％ while the symptoms were all slight.The bleeding pattern was similar to that of normal menstruation.Compared with baseline,the elevated level of triglycerides and the reduced level of low-density lipoprotein (LDL) were significantly different while no significant difference existed in high-density lipoprotein (HDL),cholesterol and hemoglobin,etc.The satisfaction rate of megestrol acetate silicone vaginal ring was 94.6％ and increased with time.Conclusion Megestrol acetate silicone vaginal ring is an effective and safe option of contraceptives.