CAJ | 학술논문

目的了解山西省2011年胃肠道间质瘤(GIST)的发病率、分布规律、临床特征等信息.方法通过医保检索及医院调查的方法收集山西省2011年1月1日至12月31日所有新诊断的及可疑GIST病例,所有病例石蜡切片后不经过染色及免疫组织化学处理由山西省肿瘤医院两位病理科医师重新分析诊断符合诊断标准的病例,分析GIST的发病率和地区及年龄分布情况等.数据采用计数资料描述.结果 2011年山西省新发现GIST病例153例,发病率为4.3/100万(2011年山西省总人口35 932 786人),中国年龄标化发病率3.6/100万,世界年龄标化发病率为2.8/100万.山西省各个地区发病人数不同,散在分布,太原和长治较多,均为25例.153例GIST患者中男83例(54.2％),女70例(45.8％),男女之比为1.19∶1.山西省统计局公布2011年人口普查男性人口数18 437 500人,女性人口数17 495 200人,男性发病率4.5/100万,女性发病率4.0/100万,男性发病率与女性发病率之间差异无统计学意义(P＞0.05).发病年龄24～79岁,中位年龄59岁,高发年龄段为55 ～59岁(33例).153例GIST中139例有病变部位的记载,其中发生在胃88例(63.3％),小肠21例(15.1％),大肠7例(5.0％),十二指肠6例(4.3％),食管3例(2.2％),胃肠道外14例(10.1％).113例GIST有肿瘤最大径的记载,中位数(范围)为5.78(0.3～25.0) cm,≤2 cm 30例(26.5％),＞2 ～5 cm 33例(29.2％),＞5～10 cm 36例(31.9％),＞10 cm 14例(12.4％).141例有细胞类型的记载,其中梭形细胞112例(79.4％),上皮型11例(7.8％),混合型18例(12.8％).结论山西省GIST是一种散在的、发病率低的疾病,男女之间发病率差异无统计学意义,太原与长治发病例数相对较多.
목적 료해산서성2011년위장도간질류(GIST)적발병솔、분포규률、림상특정등신식.방법 통과의보검색급의원조사적방법수집산서성2011년1월1일지12월31일소유신진단적급가의GIST병례,소유병례석사절편후불경과염색급면역조직화학처이유산서성종류의원량위병이과의사중신분석진단부합진단표준적병례,분석GIST적발병솔화지구급년령분포정황등.수거채용계수자료묘술.결과 2011년산서성신발현GIST병례153례,발병솔위4.3/100만(2011년산서성총인구35 932 786인),중국년령표화발병솔3.6/100만,세계년령표화발병솔위2.8/100만.산서성각개지구발병인수불동,산재분포,태원화장치교다,균위25례.153례GIST환자중남83례(54.2％),녀70례(45.8％),남녀지비위1.19∶1.산서성통계국공포2011년인구보사남성인구수18 437 500인,녀성인구수17 495 200인,남성발병솔4.5/100만,녀성발병솔4.0/100만,남성발병솔여녀성발병솔지간차이무통계학의의(P＞0.05).발병년령24～79세,중위년령59세,고발년령단위55 ～59세(33례).153례GIST중139례유병변부위적기재,기중발생재위88례(63.3％),소장21례(15.1％),대장7례(5.0％),십이지장6례(4.3％),식관3례(2.2％),위장도외14례(10.1％).113례GIST유종류최대경적기재,중위수(범위)위5.78(0.3～25.0) cm,≤2 cm 30례(26.5％),＞2 ～5 cm 33례(29.2％),＞5～10 cm 36례(31.9％),＞10 cm 14례(12.4％).141례유세포류형적기재,기중사형세포112례(79.4％),상피형11례(7.8％),혼합형18례(12.8％).결론 산서성GIST시일충산재적、발병솔저적질병,남녀지간발병솔차이무통계학의의,태원여장치발병례수상대교다.
Objective To explore the incidence and distribution of gastrointestinal stromal tumor (GIST) in Shanxi Province.Methods Newly diagnosed and suspected GIST cases of Shanxi Province on January 1,2011 to December 31,2011 were collected from medical insurance records and hospital surveys.All specimens were sent to the Department of Pathology at Shanxi Provincial Tumor Hospital for examinations.And the data were analyzed by SPSS statistical analysis software.Results There were 153 newly discovered cases of GIST in Shanxi Province in 2011.And its distribution was scattered in different regions.The incidence was 4.3 per million(153/35 932 786).The high-risk areas were Taiyuan (n =25) and Changzhi (n =25).There were 83 (54.2％) males and 70 (45.8％) females.And the incidence of males was not different from that of females((4.5 vs 4.0) per million,P ＞ 0.05).The median onset age was 59 (24-79) years.A high incidence of GIST occurred at an age range of 50-59 years (n =33).Among the 139 patients,the tumor locations were stomach (n =88,63.3％),small intestine (n =21,15.1％),colon (n=7,5.0％),duodenum (n =6,4.3％),esophagus (n=3,2.2％) and extra-gastrointestinal (n =14,10.1％).And 113 cases had a record of tumor size.The median diameter was 5.78(0.3-25.0)cm.The largest diameter was ≤2 cm (n =30,26.5％),＞2-5 cm (n =33,29.2％),＞5-10cm (n=36,31.9％) and ＞10 cm (n=14,12.4％).The cell types of 141 cases were spindle cell (n =112,79.4％),epithelial (n =11,7.8％) and mixed (n =18,12.8％).Conclusions Shanxi Province has a low incidence of GIST.And no statistically significant difference exists in the incidence between males and females.Taiyuan and Changzhi are relatively more prevalent.