中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2013年
44期
3510-3515
,共6页
李爱东%邰隽%黄育北%郭永丽%葛文彤%张杰%刘原虎%饶远生%肖潇
李愛東%邰雋%黃育北%郭永麗%葛文彤%張傑%劉原虎%饒遠生%肖瀟
리애동%태준%황육북%곽영려%갈문동%장걸%류원호%요원생%초소
鼻咽肿瘤%Meta分析%饮酒%饮茶
鼻嚥腫瘤%Meta分析%飲酒%飲茶
비인종류%Meta분석%음주%음다
Nasopharyngeal neoplasms%Meta-analysis%Alcohol drinking%Tea consumption
目的 系统评价中国人群饮酒及饮茶行为与鼻咽癌之间的关系及关联强度,为我国鼻咽癌的防治策略提供依据.方法 系统检索3个中文数据库(CNKI、万方、维普)及3个英文数据库(PubMed、ScienceDirect、SpringerLink)2013年3月之前发表的鼻咽癌病例对照研究及队列研究.文献检索、选取、信息提取及质量评价均由两人独立进行.采用基于方差倒数加权的随机效应模型合并研究结果.结果 纳入合格研究14篇(3篇队列研究,11篇病例对照研究),共涉及来自全国6个省份的鼻咽癌患者6559例,对照10 567例.在合并所有的研究之后,发现饮酒者相对不饮酒者发生鼻咽癌的风险为1.12 (95％ CI:0.98 ～1.26;I2 =44.5％,P=0.037);经常饮酒者和少量饮酒者相对不饮茶者发生鼻咽癌的风险分别为1.18(95％ CI:1.00 ～ 1.38;I2=0.0％,P=0.578)和0.76 (95％CI:0.65 ～0.89;I2 =33.4％,P=0.212).饮茶与鼻咽癌之间的关联强度为0.53 (95％CI:0.43～0.60;I2 =17.9％,P=0.301).结论 在中国,少量饮酒可能对鼻咽癌有一定的保护作用,但经常饮酒则增加鼻咽癌的风险.同时饮茶可显著降低鼻咽癌的风险.
目的 繫統評價中國人群飲酒及飲茶行為與鼻嚥癌之間的關繫及關聯彊度,為我國鼻嚥癌的防治策略提供依據.方法 繫統檢索3箇中文數據庫(CNKI、萬方、維普)及3箇英文數據庫(PubMed、ScienceDirect、SpringerLink)2013年3月之前髮錶的鼻嚥癌病例對照研究及隊列研究.文獻檢索、選取、信息提取及質量評價均由兩人獨立進行.採用基于方差倒數加權的隨機效應模型閤併研究結果.結果 納入閤格研究14篇(3篇隊列研究,11篇病例對照研究),共涉及來自全國6箇省份的鼻嚥癌患者6559例,對照10 567例.在閤併所有的研究之後,髮現飲酒者相對不飲酒者髮生鼻嚥癌的風險為1.12 (95％ CI:0.98 ～1.26;I2 =44.5％,P=0.037);經常飲酒者和少量飲酒者相對不飲茶者髮生鼻嚥癌的風險分彆為1.18(95％ CI:1.00 ～ 1.38;I2=0.0％,P=0.578)和0.76 (95％CI:0.65 ～0.89;I2 =33.4％,P=0.212).飲茶與鼻嚥癌之間的關聯彊度為0.53 (95％CI:0.43～0.60;I2 =17.9％,P=0.301).結論 在中國,少量飲酒可能對鼻嚥癌有一定的保護作用,但經常飲酒則增加鼻嚥癌的風險.同時飲茶可顯著降低鼻嚥癌的風險.
목적 계통평개중국인군음주급음다행위여비인암지간적관계급관련강도,위아국비인암적방치책략제공의거.방법 계통검색3개중문수거고(CNKI、만방、유보)급3개영문수거고(PubMed、ScienceDirect、SpringerLink)2013년3월지전발표적비인암병례대조연구급대렬연구.문헌검색、선취、신식제취급질량평개균유량인독립진행.채용기우방차도수가권적수궤효응모형합병연구결과.결과 납입합격연구14편(3편대렬연구,11편병례대조연구),공섭급래자전국6개성빈적비인암환자6559례,대조10 567례.재합병소유적연구지후,발현음주자상대불음주자발생비인암적풍험위1.12 (95％ CI:0.98 ～1.26;I2 =44.5％,P=0.037);경상음주자화소량음주자상대불음다자발생비인암적풍험분별위1.18(95％ CI:1.00 ～ 1.38;I2=0.0％,P=0.578)화0.76 (95％CI:0.65 ～0.89;I2 =33.4％,P=0.212).음다여비인암지간적관련강도위0.53 (95％CI:0.43～0.60;I2 =17.9％,P=0.301).결론 재중국,소량음주가능대비인암유일정적보호작용,단경상음주칙증가비인암적풍험.동시음다가현저강저비인암적풍험.
Objective To evaluate the relationship and strength of association for alcohol drinking and tea consumption with the riskS of nasopharynx cancer among Chinese population so as to provide control rationales for nasopharynx cancer in China.Methods A systematic search of 3 Chinese electronic databases (CNKI,VIP,Wanfang) and 3 English databases (Pubmed,ScienceDirect and SpringerLink) up to March 2013 was performed.Two reviewers independently conducted the literature search,examined eligibility and performed data extraction and quality evaluations.Pooled odd ratio (OR) value and 95％ CI value were calculated with random-effects model weighted with inverse of variances.Results A total of 14 studies (including 3 cohort and 11 case-control) involving 6559 cases of nasopharynx cancer and 10 567 controls from 6 provinces were included.The pooled OR between alcohol drinking and risks of nasopharynx cancer was 1.12 (95％ CI:0.98-1.26; I2 =44.5％,P =0.037).Compared with the non-drinkers,the risks of nasopharynx cancer for regular drinkers and occasional drinkers were 1.18 (95％ CI:1.00-1.38; I2 =0.0％,P =0.578) and 0.76 (95％ CI:0.65-0.89 ; I2 =33.4％,P =0.212).And the association of tea consumption with the risks of nasopharynx cancer was 0.53 (95％ CI:0.43-0.60; I2 =17.9％,P =0.301).Conclusions In China,occasional alcohol drinking may decrease the risks of nasopharynx cancer while regular drinking elevates the risks.And there is significantly protective effect for tea consumption on the risks of nasopharynx cancer.
