CAJ | 학술논문

目的评价尿凋亡抑制因子Livin、Survivin mRNA表达在膀胱癌早期诊断中的应用价值.方法选择南昌大学第四附属医院2008至2012年收治的52例早期膀胱尿路上皮癌和30例非泌尿系统肿瘤患者,采用PCR的方法对研究对象的尿液进行Livin和Survivin检测,并行尿脱落细胞学检查.结果病例组和对照组尿Livin和Survivin及尿脱落细胞学检查阳性分别为37、35、12例,1、2、1例;敏感度分别为71.2％、67.3％、23.1％;特异度分别为96.7％,93.3％和96.7％;尿Survivin的敏感度、特异度和Livin比较差异均无统计学意义(均P＞0.05);尿Livin和Survivin的敏感度均高于尿脱落细胞学,差异均有统计学意义(均P＜0.05).结论联合检测尿Livin、Survivin mRNA表达是无创性早期诊断膀胱癌敏感和特异的指标.
목적 평개뇨조망억제인자Livin、Survivin mRNA표체재방광암조기진단중적응용개치.방법 선택남창대학제사부속의원2008지2012년수치적52례조기방광뇨로상피암화30례비비뇨계통종류환자,채용PCR적방법대연구대상적뇨액진행Livin화Survivin검측,병행뇨탈락세포학검사.결과 병례조화대조조뇨Livin화Survivin급뇨탈락세포학검사양성분별위37、35、12례,1、2、1례;민감도분별위71.2％、67.3％、23.1％;특이도분별위96.7％,93.3％화96.7％;뇨Survivin적민감도、특이도화Livin비교차이균무통계학의의(균P＞0.05);뇨Livin화Survivin적민감도균고우뇨탈락세포학,차이균유통계학의의(균P＜0.05).결론 연합검측뇨Livin、Survivin mRNA표체시무창성조기진단방광암민감화특이적지표.
Objective To evaluate the value of urine Livin and Survivin mRNA expression in the early diagnosis of bladder cancer.Methods Fifty-two cases of early bladder cancer and 30 cases of nonurinary system tumors were selected for the combined detection of urinary Livin and Survivin and urine cytology.Results Livin and Survivin in urine and urinary cytology sensitivity were 71.2％ (37/52),67.3％ (35/52),23.1％ (12/52) ; Specificity were 96.7％ (29/30),93.3％ (28/30) and 96.7％ (29/30) respectively.Urine Survivin sensitivity,specificity compared with Livin were no significant difference (all P ＞ 0.05).Urinary Livin and Survivin were more sensitive than urine cytology,and the differences were statistically significant(all P ＜0.05).Conclusion The combined urinary detection of Livin,Survivin mRNA expression is a noninvasive early diagnosis of bladder cancer with sensitivity and specificity.