CAJ | 학술논문

目的探讨老年女性乳腺癌的临床特点及治疗选择.方法回顾分析北京医院乳腺中心1997年9月至2011年9月收治的312例老年(≥70岁)女性乳腺癌患者的临床资料及随访结果.分析其临床特点、治疗选择及影响预后的因素.结果全组312例老年乳腺癌占同期收治的2137例乳腺癌患者的14.6％.其中80.1％(250例)的患者以乳腺肿物就诊,90.4％(282例)的患者合并有其他疾病.主要病理类型为非特殊类型浸润性导管癌(248例,79.5％),雌和(或)孕激素受体阳性占75.3％(235例),Cerb-B2(+++)占15.7％(49例).全组患者5年、10年生存率分别为75.0％和41.8％.TNM分期,脉管癌栓,手术选择和辅助综合治疗是影响预后的因素.结论老年女性乳腺癌手术和内分泌治疗是最重要和有效的首选治疗方式.影响预后的主要因素是TNM分期、脉管癌栓和治疗方式的选择.
목적 탐토노년녀성유선암적림상특점급치료선택.방법 회고분석북경의원유선중심1997년9월지2011년9월수치적312례노년(≥70세)녀성유선암환자적림상자료급수방결과.분석기림상특점、치료선택급영향예후적인소.결과 전조312례노년유선암점동기수치적2137례유선암환자적14.6％.기중80.1％(250례)적환자이유선종물취진,90.4％(282례)적환자합병유기타질병.주요병리류형위비특수류형침윤성도관암(248례,79.5％),자화(혹)잉격소수체양성점75.3％(235례),Cerb-B2(+++)점15.7％(49례).전조환자5년、10년생존솔분별위75.0％화41.8％.TNM분기,맥관암전,수술선택화보조종합치료시영향예후적인소.결론 노년녀성유선암수술화내분비치료시최중요화유효적수선치료방식.영향예후적주요인소시TNM분기、맥관암전화치료방식적선택.
Objective To analyze the clinical characteristics and therapeutics of elderly patients with breast carcinomas.Methods A total of 312 patients (≥70 years old) admitted into Breast Center of Beijing Hospital from September 1997 to September 2011 were included for this retrospective study.Their clinical characteristics,treatment options and prognostic factors were analyzed.Results They accounted for 14.6％ (312/2137) of breast cancer patients treated during the same period.The predominant complaint was palpable mass (n =250,80.1％).90.4％ (n =282) of them were complicated with other diseases.The major pathologic type was invasive ductal carcinoma of non-special type (n =248,79.5％).The positive rate of estrogen receptor (ER) and (or) progesterone receptor (PR) was 75.3％ (n =235),and 15.7％ (n =49) cases were Cerb-B2 (+++).The 5,10-year overall survival were 75.0％ and 41.8％respectively.TNM stage,vascular thrombosis,operative regimen and adjuvant therapy were prognostic factors.Conclusions Surgical operation and endocrine therapy are the first choice remedies for elderly patients.And the maior prognostic factors are TNM stage,vascular thrombosis and treatment regimens.