中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2013年
44期
3526-3528
,共3页
霍立志%井汉国%王腾春%袁守娴%栾秀华%郭克存%史本康
霍立誌%井漢國%王騰春%袁守嫻%欒秀華%郭剋存%史本康
곽립지%정한국%왕등춘%원수한%란수화%곽극존%사본강
膀胱,过度活动性%药物疗法%琥珀酸索利那新%萘哌地尔
膀胱,過度活動性%藥物療法%琥珀痠索利那新%萘哌地爾
방광,과도활동성%약물요법%호박산색리나신%내고지이
Urinary bladder,overactive%Drug therapy%Solifenacin succinate%Naftopidil
目的 探讨行为训练效果不佳的女性膀胱过度活动症(OAB)患者的有效治疗方法.方法 选择2012年1月至2013年1月聊城市第二人民医院行为训练效果不佳的女性OAB患者67例,年龄19 ～57岁,平均39.8岁;病程1～16年,平均3.8年.按随机数字表法将67例患者随机分为试验组(n=24)和对照Ⅰ组(n=22)、Ⅱ组(n=21),试验组给予口服琥珀酸索利那新(5 mg口服,1次/d)及萘哌地尔(25 mg口服,每晚1次);对照Ⅰ组单纯给予琥珀酸索利那新;对照Ⅱ组单纯给予萘哌地尔.用药时间均为4周.观察试验组与对照组用药前后尿急评分、日平均排尿次数、日平均单次尿量、日单次最大尿量变化,并进行统计学分析.结果 试验组与对照Ⅰ组、Ⅱ组治疗后尿急评分、日平均排尿次数、日平均单次尿量、日单次最大尿量差异均有统计学意义[(0.8±0.1)比(1.8±0.8)、(2.1±0.9)分,(9±4)比(13±4)、(14±5)次,(295 ±79)比(211 ±67)、(185±64) ml,(352±88)比(292 ±75)、(235±69) ml,均P＜0.05].结论 琥珀酸索利那新联合萘哌地尔能够有效改善女性OAB患者的临床症状,提高生活质量.
目的 探討行為訓練效果不佳的女性膀胱過度活動癥(OAB)患者的有效治療方法.方法 選擇2012年1月至2013年1月聊城市第二人民醫院行為訓練效果不佳的女性OAB患者67例,年齡19 ～57歲,平均39.8歲;病程1～16年,平均3.8年.按隨機數字錶法將67例患者隨機分為試驗組(n=24)和對照Ⅰ組(n=22)、Ⅱ組(n=21),試驗組給予口服琥珀痠索利那新(5 mg口服,1次/d)及萘哌地爾(25 mg口服,每晚1次);對照Ⅰ組單純給予琥珀痠索利那新;對照Ⅱ組單純給予萘哌地爾.用藥時間均為4週.觀察試驗組與對照組用藥前後尿急評分、日平均排尿次數、日平均單次尿量、日單次最大尿量變化,併進行統計學分析.結果 試驗組與對照Ⅰ組、Ⅱ組治療後尿急評分、日平均排尿次數、日平均單次尿量、日單次最大尿量差異均有統計學意義[(0.8±0.1)比(1.8±0.8)、(2.1±0.9)分,(9±4)比(13±4)、(14±5)次,(295 ±79)比(211 ±67)、(185±64) ml,(352±88)比(292 ±75)、(235±69) ml,均P＜0.05].結論 琥珀痠索利那新聯閤萘哌地爾能夠有效改善女性OAB患者的臨床癥狀,提高生活質量.
목적 탐토행위훈련효과불가적녀성방광과도활동증(OAB)환자적유효치료방법.방법 선택2012년1월지2013년1월료성시제이인민의원행위훈련효과불가적녀성OAB환자67례,년령19 ～57세,평균39.8세;병정1～16년,평균3.8년.안수궤수자표법장67례환자수궤분위시험조(n=24)화대조Ⅰ조(n=22)、Ⅱ조(n=21),시험조급여구복호박산색리나신(5 mg구복,1차/d)급내고지이(25 mg구복,매만1차);대조Ⅰ조단순급여호박산색리나신;대조Ⅱ조단순급여내고지이.용약시간균위4주.관찰시험조여대조조용약전후뇨급평분、일평균배뇨차수、일평균단차뇨량、일단차최대뇨량변화,병진행통계학분석.결과 시험조여대조Ⅰ조、Ⅱ조치료후뇨급평분、일평균배뇨차수、일평균단차뇨량、일단차최대뇨량차이균유통계학의의[(0.8±0.1)비(1.8±0.8)、(2.1±0.9)분,(9±4)비(13±4)、(14±5)차,(295 ±79)비(211 ±67)、(185±64) ml,(352±88)비(292 ±75)、(235±69) ml,균P＜0.05].결론 호박산색리나신연합내고지이능구유효개선녀성OAB환자적림상증상,제고생활질량.
Objective To explore the effective therapy of female overactive bladder unresponsive to behavior training.Methods A total of 67 patients with female overactive bladder unresponsive to behavior training were enrolled from January 2012 to January 2013 at Liaocheng Second People's Hospital.They were randomized into trial and control groups(Ⅰ and Ⅱ).Their mean age was 39.8 (19-57) years.And the mean disease course was 3.8 (1-16) years.The trial group (n =24) received oral formulations of solifenacin succinate (5 mg,once a day)and naftopidil(25 mg,every evening).The control group Ⅰ (n =22) had only solifenacin succinate and the control group Ⅱ (n =21) only naftopidil.The treatment lasted for 4 weeks.The time of urination per day,average amount of mona-urination and maximum amount of monaurination were observed.The changes of all parameters before and after treatment were assessed.And statistic analysis was performed.Results The urinary urgency score of the trial,control group Ⅰ and control Ⅱ groups were 0.8 ±0.1,1.8 ±0.8,2.1 ±0.9; and the times of urination per day 9 ±4,13 ±4,14 ±5,average amount of mona-urination (295 ± 79),(211 ± 67),(185 ± 64) ml and maximum amount of monaurination (352 ± 88),(292 ± 75),(235 ± 69) ml respectively.These parameters showed significant differences between the trial and control groups (all P ＜ 0.05).Conclusion A combination of solifenacin succinate and naftopidil can effectively relieve the symptoms of female overactive bladder and improve the life quality.
