CAJ | 학술논문

目的探讨新疆维吾尔族和汉族帕金森病(PD)患者临床症状特点.方法对2008年6月至2011年9月在新疆乌鲁木齐市及南、北疆收集的91例维吾尔族和173例汉族帕金森病患者采用统一帕金森病问卷、UPDRS评定量表、Hoehn-Yahr分级量表、简易精神状态检查(MMSE)量表、日常生活能力问卷(ADCS-ADL)和神经精神问卷(NPI)进行评定,比较维吾尔族和汉族PD患者临床症状发生的特点.结果维吾尔族和汉族PD患者通过药物治疗者汉族[108例(62.34％)]多于维吾尔族[36例(39.56％),P＜0.05],但其治疗有效者两组比较差异无统计学意义(P＞0.05).维吾尔族和汉族患者Hoehn-Yahr分级差异均无统计学意义(均P＞0.05);Hoehn-Yahr分期维吾尔族和汉族PD患者中重度组比较,ADL、UPDRSⅡ与UPDRSⅢ评分差异均无统计学意义(均P＞0.05);以静止性震颤+肌张力增高+运动迟缓为首发症状维吾尔族[8例(19.05％)]多于汉族[7例(7.07％),P＜0.05];维吾尔族N型进展者比例[36例(85.71％)]多于汉族[48例(48.48％),P＜0.05];其他首发症状、首发部位以及开关现象、异动现象两组比较差异均无统计学意义(均P ＞0.05);MMSE评分与NPI评分维吾尔族和汉族差异无统计学意义(P＞0.05).结论维吾尔族和汉族PD患者典型运动症状、病情严重程度、日常生活能力、认知功能和精神症状均无差异;维吾尔族N型进展者较汉族多;而汉族在以静止性震颤+肌张力增高+运动迟缓为首发症状高于维吾尔族.
목적 탐토신강유오이족화한족파금삼병(PD)환자림상증상특점.방법 대2008년6월지2011년9월재신강오로목제시급남、북강수집적91례유오이족화173례한족파금삼병환자채용통일파금삼병문권、UPDRS평정량표、Hoehn-Yahr분급량표、간역정신상태검사(MMSE)량표、일상생활능력문권(ADCS-ADL)화신경정신문권(NPI)진행평정,비교유오이족화한족PD환자림상증상발생적특점.결과 유오이족화한족PD환자통과약물치료자한족[108례(62.34％)]다우유오이족[36례(39.56％),P＜0.05],단기치료유효자량조비교차이무통계학의의(P＞0.05).유오이족화한족환자Hoehn-Yahr분급차이균무통계학의의(균P＞0.05);Hoehn-Yahr분기유오이족화한족PD환자중중도조비교,ADL、UPDRSⅡ여UPDRSⅢ평분차이균무통계학의의(균P＞0.05);이정지성진전+기장력증고+운동지완위수발증상유오이족[8례(19.05％)]다우한족[7례(7.07％),P＜0.05];유오이족N형진전자비례[36례(85.71％)]다우한족[48례(48.48％),P＜0.05];기타수발증상、수발부위이급개관현상、이동현상량조비교차이균무통계학의의(균P ＞0.05);MMSE평분여NPI평분유오이족화한족차이무통계학의의(P＞0.05).결론 유오이족화한족PD환자전형운동증상、병정엄중정도、일상생활능력、인지공능화정신증상균무차이;유오이족N형진전자교한족다;이한족재이정지성진전+기장력증고+운동지완위수발증상고우유오이족.
Objective To explore the characteristics of clinical symptoms in Uygur and Han patients with Parkinson's disease (PD).Methods The unified Parkinson's disease rating scale (UPDRS),Hoehn-Yahr,mini-mental state examination (MMSE) scale,Alzheimer disease cooperative study-activities of daily living (ADCS-ADL) and neuropsychiatric inventory (NPI) were administered to 91 Uygur and 173 Han PD patients from Xinjiang Urumqi and surrounding region from June 2008 to September 2011 to compare the characteristics of clinical symptoms between Uygnr and Han patients.Results The subjects of drug treatment in Han [108 (62.34％)] were more than in Uygur [36 (39.56％),(P ＜ 0.05)].However there were no significant differences in the subjects of effective treatment between two groups (P ＞ 0.05).No significant inter-group differences existed in the scores of Hoehn-Yahr (P ＞ 0.05).Compare with moderate and severe group in Hoehn-Yahr,there were no significant differences in the scores of ADL,UPDRS Ⅱ and UPDRS Ⅲ between two groups (P ＞ 0.05).The subjects of resting tremor,increased muscle tone and bradykinesia as the presenting symptoms in Uygur [8 (19.05％)] were more than in Han [7 (7.07％),(P ＜0.05)].And the subjects of N-type progressive in Uygur [36 (85.71％)] were more than in Han [48 (48.48％),(P ＜ 0.05)].There were no significant differences in other presenting symptoms,initial site,on-off phenomenon and dyskinesia between two groups (P ＞ 0.05).No significant differences existed in the scores of MMSE and NPI between two groups (P ＞ 0.05).Conclusion No significant differences exist in typical motor symptoms,severity of disease,activities of daily living,cognitive dysfuntion and psychiatric symptoms between Uygur and Han.But N-type progressive is more common in Uygur.And the presenting symptoms of resting tremor,increased muscle tone and bradykinesia are also higher in Uygur.