CAJ | 학술논문

目的研究新辅助放化疗对中低位直肠癌患者肛门直肠功能的影响.方法选取中国医学科学院北京协和医院2012年10月至2013年11月期间确诊为中低位直肠癌、拟行新辅助放化疗的22例患者,男14例,女8例,年龄(59±10)岁;在放化疗前和放疗结束后6周进行排便症状的评估和三维高分辨肛门直肠压力测定.结果新辅助放化疗后,22例患者中21例的排便症状(包括排便次数增加、粪便性状异常、便血和排便急迫感等)显著改善;其中8例低位直肠癌患者在新辅助放化疗后肛门括约肌高压带长度显著增加[(3.84±0.61)比(2.96±0.80)cm,P=0.003],肛门直肠测压其他指标无明显变化(均P＞0.05).结论新辅助放化疗在发挥对肿瘤降期作用的同时,可显著改善中低位直肠癌患者的排便症状,增加低位直肠癌患者肛门括约肌高压带长度.
목적 연구신보조방화료대중저위직장암환자항문직장공능적영향.방법 선취중국의학과학원북경협화의원2012년10월지2013년11월기간학진위중저위직장암、의행신보조방화료적22례환자,남14례,녀8례,년령(59±10)세;재방화료전화방료결속후6주진행배편증상적평고화삼유고분변항문직장압력측정.결과 신보조방화료후,22례환자중21례적배편증상(포괄배편차수증가、분편성상이상、편혈화배편급박감등)현저개선;기중8례저위직장암환자재신보조방화료후항문괄약기고압대장도현저증가[(3.84±0.61)비(2.96±0.80)cm,P=0.003],항문직장측압기타지표무명현변화(균P＞0.05).결론 신보조방화료재발휘대종류강기작용적동시,가현저개선중저위직장암환자적배편증상,증가저위직장암환자항문괄약기고압대장도.
Objective To evaluate the effects of neoadjuvant chemoradiotherapy on anorectal function in patients with mid and low rectal cancer.Methods A total of 22 patients with mid and low rectal cancer were enrolled into this study from October 2012 to November 2013.There were 14 males and 8 females with a mean age of(59 ± 10)years.We collected the defecation-related symptoms with questionnaire interview and evaluated the anorectal function with three-dimensional high-resolution manometry before neoadjuvant chemoradiotherapy and at 6 weeks after radiotherapy.Results The defecation-related symptoms (including increase in stool frequency,change in stool form,hematochezia and urgency,etc.) improved significantly after neoadjuvant chemoradiotherapy (n =21).Among those with lower rectal cancer (n =8),the length of high-pressure zone in manometry increased significantly after neoadjuvant chemoradiotherapy ((3.84 ± 0.61) vs (2.96 ± 0.80) cm,P =0.003).However,there was no significant change for other parameters in anorectal function(all P ＞ 0.05).Conclusions In patients with mid and low rectal cancer,neoadjuvant chemoradiotherapy may improve the defecation symptoms and enhance anal sphincter high-pressure zone for lower rectal cancer.And it is probably due to its tumor-downsizing effect.