CAJ | 학술논문

目的在手术切除及放化疗基础上,探索对脑胶质母细胞瘤病人进行热量限制性饮食联合引导良好的心理状态以及与化疗同步的高压氧治疗,是否可以明显延长病人的术后生存期.方法采用前瞻性、非随机、非双盲及对照实验方法,对象为2007年11月至2009年4月在北京天坛医院或北京天坛普华医院手术治疗的病人,共34例.所有病例均为肿瘤全切(90％以上),分子病理学证实为脑胶质母细胞瘤.其中实验组11例,对照组23例.实验组的治疗是在手术及放化疗的基础上,进行热量限制性饮食、心理引导及与化疗同步的高压氧治疗.对照组仅进行手术及放化疗.结果实验组病人生存期(38 ± 13)个月,对照组病人生存期(20±12)个月,两组比较差异有统计学意义(P＜0.05).结论热量限制性饮食联合心理引导及与化疗同步进行高压氧辅助治疗,可以明显延长脑胶质母细胞瘤病人的生存期.
목적 재수술절제급방화료기출상,탐색대뇌효질모세포류병인진행열량한제성음식연합인도량호적심리상태이급여화료동보적고압양치료,시부가이명현연장병인적술후생존기.방법 채용전첨성、비수궤、비쌍맹급대조실험방법,대상위2007년11월지2009년4월재북경천단의원혹북경천단보화의원수술치료적병인,공34례.소유병례균위종류전절(90％이상),분자병이학증실위뇌효질모세포류.기중실험조11례,대조조23례.실험조적치료시재수술급방화료적기출상,진행열량한제성음식、심리인도급여화료동보적고압양치료.대조조부진행수술급방화료.결과 실험조병인생존기(38 ± 13)개월,대조조병인생존기(20±12)개월,량조비교차이유통계학의의(P＜0.05).결론 열량한제성음식연합심리인도급여화료동보진행고압양보조치료,가이명현연장뇌효질모세포류병인적생존기.
Objective To explore the influence of caloric restrction combined with psychotherapy and chemotherapy associated by hybaroxia on the prognosis of patients with intracranial glioblastoma multiforme.Methods This was a perspective,nonrandom,no-double-blinded controlled study.All patients underwent total resection during November 2007 to April 2009 at Beijing Tiantan Hospital and Beijing Tiantan Puhua Hospital.All diagnoses were confirmed by molecule pathology.While 23 patients in control group underwent resections and radiochemotherapy,11 patients in experimental group were further treated by caloric restriction plus psychotherapy and chemotherapy-associated hybaroxia.The life spans were compared between two groups.Results The mean survival time of patients in experimental group was (38 ± 13) months versus (20 ± 12) months in control group.The survival time of patients in experimental group was significantly longer than that in control group (P ＜ 0.05).Conclusion Caloric restriction plus psychotherapy and chemotherapy-associated hybaroxia can apparently prolong the life span of patients with glioblastoma multiforme.