中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2014年
27期
2135-2138
,共4页
王维卓%王美豪%刘会茹%原彬科%汪娟%李海燕%周晓军%王欣%陶洁洁
王維卓%王美豪%劉會茹%原彬科%汪娟%李海燕%週曉軍%王訢%陶潔潔
왕유탁%왕미호%류회여%원빈과%왕연%리해연%주효군%왕흔%도길길
运动性失语症%脑梗死%功能磁共振成像%静息态%功能连接
運動性失語癥%腦梗死%功能磁共振成像%靜息態%功能連接
운동성실어증%뇌경사%공능자공진성상%정식태%공능련접
Motor aphasia%Ischemia stroke%Functional magnetic resonance imaging%Resting-state%Functional connectivity
目的 应用功能磁共振成像(fMRI)研究静息态脑梗死运动性失语症患者Broca区的功能连接.方法 选取温州医科大学附属第一医院2012-2013年因初次脑梗死就诊的患者及健康对照组.患者组与健康对照组各10例,男6例、女4例,组间性别匹配.观察Broca区与全脑脑区低频信号的波动相关性,分析Broca区的功能连接.结果 健康对照组静息态下多个脑区体素(voxel)与Broca区低频信号波动呈正相关.患者组与健康对照组相比,Broca区与其周围邻近脑区的功能连接增强最显著,而其对侧半球脑区与Broca区的功能连接降低,但与部分小脑、枕叶、颞中回及胼胝体压部的功能连接增强.结论 静息态存在广泛的运动性语言功能网络,右前扣带回、胼胝体膝及半球在运动性语言功能网络中发挥重要作用,Broca区周围邻近脑区及右小脑、枕叶、颞中回及胼胝体压部与Broca区功能连接增强可能是脑梗死运动性失语症患者语言恢复的重塑代偿机制之一.
目的 應用功能磁共振成像(fMRI)研究靜息態腦梗死運動性失語癥患者Broca區的功能連接.方法 選取溫州醫科大學附屬第一醫院2012-2013年因初次腦梗死就診的患者及健康對照組.患者組與健康對照組各10例,男6例、女4例,組間性彆匹配.觀察Broca區與全腦腦區低頻信號的波動相關性,分析Broca區的功能連接.結果 健康對照組靜息態下多箇腦區體素(voxel)與Broca區低頻信號波動呈正相關.患者組與健康對照組相比,Broca區與其週圍鄰近腦區的功能連接增彊最顯著,而其對側半毬腦區與Broca區的功能連接降低,但與部分小腦、枕葉、顳中迴及胼胝體壓部的功能連接增彊.結論 靜息態存在廣汎的運動性語言功能網絡,右前釦帶迴、胼胝體膝及半毬在運動性語言功能網絡中髮揮重要作用,Broca區週圍鄰近腦區及右小腦、枕葉、顳中迴及胼胝體壓部與Broca區功能連接增彊可能是腦梗死運動性失語癥患者語言恢複的重塑代償機製之一.
목적 응용공능자공진성상(fMRI)연구정식태뇌경사운동성실어증환자Broca구적공능련접.방법 선취온주의과대학부속제일의원2012-2013년인초차뇌경사취진적환자급건강대조조.환자조여건강대조조각10례,남6례、녀4례,조간성별필배.관찰Broca구여전뇌뇌구저빈신호적파동상관성,분석Broca구적공능련접.결과 건강대조조정식태하다개뇌구체소(voxel)여Broca구저빈신호파동정정상관.환자조여건강대조조상비,Broca구여기주위린근뇌구적공능련접증강최현저,이기대측반구뇌구여Broca구적공능련접강저,단여부분소뇌、침협、섭중회급변지체압부적공능련접증강.결론 정식태존재엄범적운동성어언공능망락,우전구대회、변지체슬급반구재운동성어언공능망락중발휘중요작용,Broca구주위린근뇌구급우소뇌、침협、섭중회급변지체압부여Broca구공능련접증강가능시뇌경사운동성실어증환자어언회복적중소대상궤제지일.
Objective To investigate the changes of Broca's area functional connectivity in ischemia stroke patients with motor aphasia during resting state using functional magnetic resonance imaging (fMRI).Methods The functional connectivity of Broca's area was analyzed by observing the correlation between low frequency signal fluctuations in Broca's area and those in all brain regions.Results In the normal controls group,there was multiple brain area positively correlated with Broca's area during resting state.The patients group compared with controls group,the functional connectivity between Broca's area and adjacent brain regions around its is most significant,and its controlateral brain area correlated with Broca's area reduced,but some cerebellum,occipital lobe,middle temporal gyrus and corpus callosum spenium correlated with Broca's area strengthened.Conclusion There is a wide range of motor function of language network during resting state.The right anterior cingulate gyrus,knee of corpus callosum and hemisphere play an important part in motor language function network.The enhancement functional connectivity between the adjacent brain regions surrounding Broca's area,the right cerebellum,occipital lobe,middle temporal gyrus and spenium of corpus callosum and Broca's area may be one compensatory mechanism remodeling for the language recover of ischemia stroke patients with motor aphasia.
