CAJ | 학술논문

目的分析三阴性乳腺癌复发的特征,并与临床病理特征进行相关性分析,了解三阴性乳腺癌的预后情况.方法统计2003年9月至2008年9月天津医科大学肿瘤医院收治的4 579例乳腺癌患者为对象,其中三阴性乳腺癌患者共787例,对其临床病理特征、复发时间和类型以及预后进行相关性分析.结果在中位随访期72(9 ～116)个月的随访中,187例(23.8％)三阴性乳腺癌患者发生复发,与非三阴性乳腺癌组17.4％的复发率相比差异有统计学意义(P=0.024);其中位复发时间是30.2(4～110)个月,2年内发生复发的患者占36.3％,2～3年内发生复发者占27.8％.三阴性乳腺癌患者发生肺、肝、脑等转移的概率均高于非三阴性乳腺癌,且更易发生局部复发(P=0.009).三阴性乳腺癌复发转移的危险因素包括:年轻,腋窝淋巴结转移,较大的原发瘤以及较晚的临床分期.结论三阴性乳腺癌具有其独特的复发特征,三阴性乳腺癌患者易在诊断后早期发生复发,且发生内脏转移的比例高于骨转移,同时发生局部复发的比例高.
목적 분석삼음성유선암복발적특정,병여림상병리특정진행상관성분석,료해삼음성유선암적예후정황.방법 통계2003년9월지2008년9월천진의과대학종류의원수치적4 579례유선암환자위대상,기중삼음성유선암환자공787례,대기림상병리특정、복발시간화류형이급예후진행상관성분석.결과 재중위수방기72(9 ～116)개월적수방중,187례(23.8％)삼음성유선암환자발생복발,여비삼음성유선암조17.4％적복발솔상비차이유통계학의의(P=0.024);기중위복발시간시30.2(4～110)개월,2년내발생복발적환자점36.3％,2～3년내발생복발자점27.8％.삼음성유선암환자발생폐、간、뇌등전이적개솔균고우비삼음성유선암,차경역발생국부복발(P=0.009).삼음성유선암복발전이적위험인소포괄:년경,액와림파결전이,교대적원발류이급교만적림상분기.결론 삼음성유선암구유기독특적복발특정,삼음성유선암환자역재진단후조기발생복발,차발생내장전이적비례고우골전이,동시발생국부복발적비례고.
Objective To analyze the recurrence characteristics of triple-negative breast cancer (TNBC) and explore their clinicopathological correlations in northern China.Methods Regression analyses were performed for 4 579 breast cancer patients from September 2002 to September 2007.Among them,there were 787 TNBC patients.Results The median follow-up period was 72 (9-116) months.And 187 (23.8％) TNBC patients recurred and it was significantly different from the recurrence rate of nonTNBC group (17.4％,P =0.024).The median time to recurrence was 30.2 (4-110) months and 36.3％ recurred 2 years while 27.8％ did within 2-3 years.The rates of lung,liver and brain metastases to other sites were higher in TNBC patients than those in non-TNBC patients.TNBC patients had higher local recurrence rates than non-TNBC counterparts (2.92％ vs 1.56％) (P =0.009).Age,regional lymph node infiltration,tumor size and pathological stage were all independent prognostic factors of TNBC.Conclusion TNBC has unique recurrence characteristics.It is prone to recur shortly with a high local recurrence rate.Metastatic rate is higher in visceral organ than bone.