CAJ | 학술논문

目的探讨北京地区新生儿网织红细胞(RET)百分比的参考区间及RET与新生儿日龄的关系.方法选取北京同仁医院2007年1月至2012年12月期间出生的新生儿2 759名,其中男1 404名,女1 355名,平均日龄4.31d.用Sysmex XE-2100血液分析仪检测网织红细胞百分比,仪器使用前对仪器进行校准.RET变量做平方根反正弦变换后,统计结果以(x)±s表示,以双侧(x)±1.96 s作为网织红细胞参考区间.按照新生儿日龄分为9组,采用独立样本资料t检验比较不同性别新生儿间RET差异;采用单因素方差分析比较不同日龄新生儿组间RET差异,两两比较采用Bonferroni调整法.结果男、女新生儿RET的参考区间分别为2.408％～ 3.438％、2.740％～3.912％.男性新生儿RET低于女性新生儿,差异有统计学意义(t=-2.564,P＜0.05).不同日龄新生儿RET差异有统计学意义(F=138.105,P＜0.01).同日龄男、女RET差异比较,第5天组男、女新生儿网织红细胞分别为(2.656±0.067)％、(3.295±0.149)％,差异有统计学意义(t=-2.219,P＜0.05).新生儿RET随日龄变化而变化,有明显的峰值.结论正常新生儿RET男女间有差异,随着日龄变化而变化.针对不同性别及日龄的新生儿网织红细胞参考区间的确定可为临床疾病诊断、治疗提供参考依据.
목적 탐토북경지구신생인망직홍세포(RET)백분비적삼고구간급RET여신생인일령적관계.방법 선취북경동인의원2007년1월지2012년12월기간출생적신생인2 759명,기중남1 404명,녀1 355명,평균일령4.31d.용Sysmex XE-2100혈액분석의검측망직홍세포백분비,의기사용전대의기진행교준.RET변량주평방근반정현변환후,통계결과이(x)±s표시,이쌍측(x)±1.96 s작위망직홍세포삼고구간.안조신생인일령분위9조,채용독립양본자료t검험비교불동성별신생인간RET차이;채용단인소방차분석비교불동일령신생인조간RET차이,량량비교채용Bonferroni조정법.결과 남、녀신생인RET적삼고구간분별위2.408％～ 3.438％、2.740％～3.912％.남성신생인RET저우녀성신생인,차이유통계학의의(t=-2.564,P＜0.05).불동일령신생인RET차이유통계학의의(F=138.105,P＜0.01).동일령남、녀RET차이비교,제5천조남、녀신생인망직홍세포분별위(2.656±0.067)％、(3.295±0.149)％,차이유통계학의의(t=-2.219,P＜0.05).신생인RET수일령변화이변화,유명현적봉치.결론 정상신생인RET남녀간유차이,수착일령변화이변화.침대불동성별급일령적신생인망직홍세포삼고구간적학정가위림상질병진단、치료제공삼고의거.
Objective To explore the RET reference values of newborns in Beijing Area and the relationship between the RET and the day ages of newborns.Methods 2 759 (1 404 males and 1 355 females) healthy newborns (born in Beijing Tongren Hospital from January 2007 to December 2012 with 4.31 average day age) were selected,the RET percentage was counted with XE-2100 (adjusted before in use),after the inverse sine transformation of variable's square root,Statistical results show as (x) ± s,the reference value refers to bilateral (x) ± 1.96 s.The sample was divided into nine groups according to different day ages.Independent sample t served to test and compare the RET difference between two genders newborns,single-factor analysis of variance served to compare the RET difference of the different day ages newborns'groups,Bonferroni adjustment method served to apply the pairwise comparisons.SPSS 18 was used for statistical analysis between males and females across nine age groups.Results The normal RET reference values of male and female newborns separately were 2.408％-3.438％,2.740％-3.912％.RET of male newborns was lower than that of female newborns,the difference was statistically significant (t =-2.564,P ＜ 0.05).The RET difference of different day ages of male and female newborns was statistically significant (F =138.105,P ＜ 0.01).The comparison of the same day newborns proves that there is RET difference between the male,female newborns of fifth day groups,respectively (2.656 ± 0.067)％,(3.295 ± 0.149)％,there is statistically significant(t =-2.219,P ＜0.05).Newborns' RET vary with day ages,and there is obvious peak value.Conclusions There is RET difference between the male and female newborns,which vary with day ages.The study on the RET reference values of newborns of different genders or different day ages contributes to the clinical disease diagnosis and treatment as reference.