中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2014年
30期
2366-2368
,共3页
舒畅%渠涛%贾力%舒丹%陈典%闫翠彦%赵文玲%任荣鑫%孙秋宁
舒暢%渠濤%賈力%舒丹%陳典%閆翠彥%趙文玲%任榮鑫%孫鞦寧
서창%거도%가력%서단%진전%염취언%조문령%임영흠%손추저
药物过敏%药疹%回顾性研究%药物不良反应
藥物過敏%藥疹%迴顧性研究%藥物不良反應
약물과민%약진%회고성연구%약물불량반응
Drug hypersensitivity%Drug eruptions%Retrospective studies%Adverse drug reactions
目的 分析药物超敏反应综合征(DHS)的临床特点.方法 回顾性分析北京协和医院2011年1月至2014年2月住院患者中确诊的10例DHS病例资料,归纳其临床特点,总结DHS的发病规律.结果 10例患者中男4例,女6例.发病年龄17 ~66岁.可疑致敏药物分别为抗惊厥药5例,别嘌呤醇2例,抗生素1例,对乙酰氨基酚1例,不详1例.10例患者均于用药后14 ~60 d出现皮疹伴发热,6例出现淋巴结肿大.皮疹中以麻疹样皮疹最常见(6例),7例患者出现面部肿胀.10例患者均有不同程度嗜酸粒细胞升高.9例患者肝受累.自身抗体异常不常见,部分患者合并病毒感染.10例患者均予糖皮质激素治疗,3例重症患者予静脉输注人免疫球蛋白(IVIg).7例好转出院,2例最终诊为非霍奇金淋巴瘤,1例住院期间死亡.结论 DHS病情复杂,常见致敏药物为抗惊厥药、别嘌呤醇、解热镇痛药及抗生素.部分病例可能存在误诊,需长期随访.
目的 分析藥物超敏反應綜閤徵(DHS)的臨床特點.方法 迴顧性分析北京協和醫院2011年1月至2014年2月住院患者中確診的10例DHS病例資料,歸納其臨床特點,總結DHS的髮病規律.結果 10例患者中男4例,女6例.髮病年齡17 ~66歲.可疑緻敏藥物分彆為抗驚厥藥5例,彆嘌呤醇2例,抗生素1例,對乙酰氨基酚1例,不詳1例.10例患者均于用藥後14 ~60 d齣現皮疹伴髮熱,6例齣現淋巴結腫大.皮疹中以痳疹樣皮疹最常見(6例),7例患者齣現麵部腫脹.10例患者均有不同程度嗜痠粒細胞升高.9例患者肝受纍.自身抗體異常不常見,部分患者閤併病毒感染.10例患者均予糖皮質激素治療,3例重癥患者予靜脈輸註人免疫毬蛋白(IVIg).7例好轉齣院,2例最終診為非霍奇金淋巴瘤,1例住院期間死亡.結論 DHS病情複雜,常見緻敏藥物為抗驚厥藥、彆嘌呤醇、解熱鎮痛藥及抗生素.部分病例可能存在誤診,需長期隨訪.
목적 분석약물초민반응종합정(DHS)적림상특점.방법 회고성분석북경협화의원2011년1월지2014년2월주원환자중학진적10례DHS병례자료,귀납기림상특점,총결DHS적발병규률.결과 10례환자중남4례,녀6례.발병년령17 ~66세.가의치민약물분별위항량궐약5례,별표령순2례,항생소1례,대을선안기분1례,불상1례.10례환자균우용약후14 ~60 d출현피진반발열,6례출현림파결종대.피진중이마진양피진최상견(6례),7례환자출현면부종창.10례환자균유불동정도기산립세포승고.9례환자간수루.자신항체이상불상견,부분환자합병병독감염.10례환자균여당피질격소치료,3례중증환자여정맥수주인면역구단백(IVIg).7례호전출원,2례최종진위비곽기금림파류,1례주원기간사망.결론 DHS병정복잡,상견치민약물위항량궐약、별표령순、해열진통약급항생소.부분병례가능존재오진,수장기수방.
Objective To characterize the clinical characteristics of drug hypersensitivity syndrome (DHS).Methods The clinical characteristics of 10 DHS patients admitted into our hospital were analyzed retrospectively.And the occurrence patterns of DHS were summarized.Results There were 4 males and 6 females with an age range of 17 to 66 years.Suspected drugs were anticonvulsants (n =5),allopurinol (n =2),antibiotics (n =1),acetaminophen (n =1) and unknown (n =1).All cases developed skin rashes with fever within 14 to 60 days (n =10).Lymphadenopathy was observed (n =6).Morbilliform eruption was most common skin rash (n =6) ; facial swelling was also appeared (n =7).Eosinophilia was observed in all cases (n =10).Liver involvement was common (n =9).Autoimmune antibodies abnormality was uncommon ; viral infection was complication in several cases.Glucocorticoids were applied in all cases (n =10),3 severe cases were administrated with intravenous immunoglobulin (IVIg).The clinical outcomes included discharging with recovery (n =7),later diagnosed of non-Hodgkin lymphoma (n =2) and inhospital death (n =1).Conclusions The clinical manifestations of DHS are complicated.And the common reactive drugs include anticonvulsants,allopurinol,antiinflammatory drugs and antibiotics.Some cases may be misdiagnosed and long-term follow-ups are required.