中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2014年
33期
2573-2575
,共3页
放射学,介入性%碘同位素%近距离放射疗法
放射學,介入性%碘同位素%近距離放射療法
방사학,개입성%전동위소%근거리방사요법
Radiology,interventional%Iodine isotopes%Brachytherapy
目的 探讨CT引导下植入125I放射粒子治疗脊柱溶骨性转移瘤的方法、疗效、安全性.方法 回顾分析山东省平阴县人民医院放射科和青岛大学附属医院介入医学中心自2004年9月至2012年3月收治的31例脊柱溶骨性转移瘤患者,行CT引导下经皮穿刺植入125I放射粒子治疗.应用放射性粒子近距离治疗计划系统(BI-TPSTM)计划125I放射粒子的活度和用量,处方剂量PD为110 ～ 140 Gy,粒子活度为26.0 ～ 29.6 Mbq/颗,术后行CT扫描并进行质量验证,定期CT随访,分析疗效.31例脊柱溶骨性转移瘤患者,分别于术后2、4、6、12个月复查CT,观察肿瘤变化,统计肿瘤局部控制有效率(RR),评价疼痛缓解情况.结果 19例合并椎旁软组织肿块患者2、4、6、12个月肿瘤RR依次是:19/19、19/19、18/19、17/19例;31例患者治疗后2、4、6、12个月疼痛降低1～3级的缓解率依次是96.8％ (30/31)、96.8％ (30/31)、90.3％ (28/31)、71.0％ (22/31);3例(9.68％)在植入部位被破坏的骨质内出现了明显的骨化.12例治疗后1个月出现皮肤色素沉着,未见脊髓坏死和皮肤溃疡.结论 CT引导下植入125I放射粒子治疗脊柱溶骨性转移瘤,疗效可靠、安全性高.
目的 探討CT引導下植入125I放射粒子治療脊柱溶骨性轉移瘤的方法、療效、安全性.方法 迴顧分析山東省平陰縣人民醫院放射科和青島大學附屬醫院介入醫學中心自2004年9月至2012年3月收治的31例脊柱溶骨性轉移瘤患者,行CT引導下經皮穿刺植入125I放射粒子治療.應用放射性粒子近距離治療計劃繫統(BI-TPSTM)計劃125I放射粒子的活度和用量,處方劑量PD為110 ～ 140 Gy,粒子活度為26.0 ～ 29.6 Mbq/顆,術後行CT掃描併進行質量驗證,定期CT隨訪,分析療效.31例脊柱溶骨性轉移瘤患者,分彆于術後2、4、6、12箇月複查CT,觀察腫瘤變化,統計腫瘤跼部控製有效率(RR),評價疼痛緩解情況.結果 19例閤併椎徬軟組織腫塊患者2、4、6、12箇月腫瘤RR依次是:19/19、19/19、18/19、17/19例;31例患者治療後2、4、6、12箇月疼痛降低1～3級的緩解率依次是96.8％ (30/31)、96.8％ (30/31)、90.3％ (28/31)、71.0％ (22/31);3例(9.68％)在植入部位被破壞的骨質內齣現瞭明顯的骨化.12例治療後1箇月齣現皮膚色素沉著,未見脊髓壞死和皮膚潰瘍.結論 CT引導下植入125I放射粒子治療脊柱溶骨性轉移瘤,療效可靠、安全性高.
목적 탐토CT인도하식입125I방사입자치료척주용골성전이류적방법、료효、안전성.방법 회고분석산동성평음현인민의원방사과화청도대학부속의원개입의학중심자2004년9월지2012년3월수치적31례척주용골성전이류환자,행CT인도하경피천자식입125I방사입자치료.응용방사성입자근거리치료계화계통(BI-TPSTM)계화125I방사입자적활도화용량,처방제량PD위110 ～ 140 Gy,입자활도위26.0 ～ 29.6 Mbq/과,술후행CT소묘병진행질량험증,정기CT수방,분석료효.31례척주용골성전이류환자,분별우술후2、4、6、12개월복사CT,관찰종류변화,통계종류국부공제유효솔(RR),평개동통완해정황.결과 19례합병추방연조직종괴환자2、4、6、12개월종류RR의차시:19/19、19/19、18/19、17/19례;31례환자치료후2、4、6、12개월동통강저1～3급적완해솔의차시96.8％ (30/31)、96.8％ (30/31)、90.3％ (28/31)、71.0％ (22/31);3례(9.68％)재식입부위피파배적골질내출현료명현적골화.12례치료후1개월출현피부색소침착,미견척수배사화피부궤양.결론 CT인도하식입125I방사입자치료척주용골성전이류,료효가고、안전성고.
Objective To discuss the method,safety and effect of embedding 125I to Brachytherapy vertebral column metastasis tumor by CT guided.Methods 31 cases of vertebral column metastasis tumor were treated with percutaneous embedding 125I by CT guided.They were observed the preoperative size and contour of lesions and were planed the activity and dosage of 125I,the PD (prescribed dose) was 110-140 Gy,and the particle activity was 26.0-29.6 Mbq.CT scanning and therapeutic effect analysis were immediately carried out after operations.We also made CT scanning regularly to analyze the effect.Results 31 cases of vertebral column metastasis tumor were respectively re-examed of CT in 2,4,6 and 12 months after operation.We surveyed the local rate,evaluate the easement of pain and observed the tumor.The local response rate of 19 cases with paravertebral mass was 19/19,19/19,18/19,17/19 cases in turn.The probability of odynolysis 31cases after 2,4,6 months therapy was 96.8％ (30/31),96.8％ (30/31),90.3％ (28/31),71.0％ (22/31)in turn.9.68％ of 31 cases that was happened significant ossification in the devastated vertebral body.12 cases appeared skin pigmentation without myelodiastasis or cutaneous ulcer.Conclusion The method to treat the vertebral column metastasis tumor of embedding 125I by CT guided was simple,reliable and safety.
