CAJ | 학술논문

目的对比分析初诊不同亚型非霍奇金淋巴瘤(NHL)患者病灶的代谢活性,探讨其与免疫表型之间的相关性.方法回顾性分析北京大学第一医院核医学科2010年7月至2012年3月行18氟-氟代脱氧葡萄糖(18F-FDG) PET/CT显像的NHL患者资料.测量反映肿瘤代谢活性的最大标准化摄取值(SUVmax),分析惰性B细胞NHL、侵袭性B细胞NHL及T细胞NHL SUVmax平均值之间的差异及SUVmax与免疫表型之间的相关性.结果本组患者中,NHL SUVmax 0.9～40.3不等,96.3％(79/82)的患者病灶均可见较明显的18F-FDG摄取.同一淋巴瘤亚型之间SUVmax也明显不同.惰性B细胞NHL、侵袭性B细胞NHL、T细胞NHL SUVmax分别为4.5±2.4、13.1士7.6、8.0士3.8.惰性B细胞NHL SUVmax低于侵袭性B细胞NHL、T细胞NHL(P=0.000、P=0.03);侵袭性B细胞NHL SUVmax高于惰性B细胞NHL、T细胞NHL SUVmax(P=0.000、P=0.005).B细胞NHLSUVmax与Ki-67阳性率呈正相关(r=0.493,P=0.001),与CD138表达呈负相关(r=-0.654,P=0.008).T细胞NHL SUVmax与Ki-67阳性率无相关(P =0.213),与CD56表达呈负相关(r=-0.545,P=0.044).结论不同NHL亚型FDG摄取明显不同,多数亚型呈FDG高摄取.惰性B细胞NHL代谢活性明显低于侵袭性B细胞NHL、T细胞NHL,侵袭性B细胞NHL代谢活性高于惰性B细胞NHL、T细胞NHL.B细胞NHL SUVmax与Ki-67表达呈正相关,与CD138表达呈负相关;T细胞NHL SUVmax与Ki-67表达无相关性,与CD56表达呈负相关.
목적 대비분석초진불동아형비곽기금림파류(NHL)환자병조적대사활성,탐토기여면역표형지간적상관성.방법 회고성분석북경대학제일의원핵의학과2010년7월지2012년3월행18불-불대탈양포도당(18F-FDG) PET/CT현상적NHL환자자료.측량반영종류대사활성적최대표준화섭취치(SUVmax),분석타성B세포NHL、침습성B세포NHL급T세포NHL SUVmax평균치지간적차이급SUVmax여면역표형지간적상관성.결과 본조환자중,NHL SUVmax 0.9～40.3불등,96.3％(79/82)적환자병조균가견교명현적18F-FDG섭취.동일림파류아형지간SUVmax야명현불동.타성B세포NHL、침습성B세포NHL、T세포NHL SUVmax분별위4.5±2.4、13.1사7.6、8.0사3.8.타성B세포NHL SUVmax저우침습성B세포NHL、T세포NHL(P=0.000、P=0.03);침습성B세포NHL SUVmax고우타성B세포NHL、T세포NHL SUVmax(P=0.000、P=0.005).B세포NHLSUVmax여Ki-67양성솔정정상관(r=0.493,P=0.001),여CD138표체정부상관(r=-0.654,P=0.008).T세포NHL SUVmax여Ki-67양성솔무상관(P =0.213),여CD56표체정부상관(r=-0.545,P=0.044).결론 불동NHL아형FDG섭취명현불동,다수아형정FDG고섭취.타성B세포NHL대사활성명현저우침습성B세포NHL、T세포NHL,침습성B세포NHL대사활성고우타성B세포NHL、T세포NHL.B세포NHL SUVmax여Ki-67표체정정상관,여CD138표체정부상관;T세포NHL SUVmax여Ki-67표체무상관성,여CD56표체정부상관.
Objective To compare the metabolic activity by 18F-fluorodeoxyglucose (18F-FDG)uptake across the various histologic subtypes of non-Hodgkin lymphoma (NHL) and to investigate the relationship between metabolic activity and immunophenotype.Methods Positron emission tomography/computed tomography (PET/CT) studies of patients with newly diagnosed NHL from Jul 2010 to Mar 2012 were retrospectively reviewed,82 patients were enrolled in our study according to the inclusion and exclusion criteria.The maximum standardized uptake value (SUVmax) of each patient reflecting the metabolic activity was recorded.Mean SUVmax of aggressive B-cell NHL,indolent B-cell NHL and T-cell NHL were compared.Pearson and Spearman test were used to analyze the relationship between SUVmax and immunophenotype.Results The SUVmax of various subtypes of lymphoma revealed a wide range from 0.9 to 40.3,but lesions of 79 patients in this study showed obviously FDG uptake.SUVmax of indolent B-cell NHL (4.5 ±2.4) was significantly lower than that of aggressive B-cell NHL (13.1 ±7.6) (P =0.000),T-cell NHL (8.0 ± 3.8) (P =0.03).SUVmax of aggressive B-cell NHL was significantly higher than that of indolent B-cell NHL,T-cell NHL (P =0.000,P =0.005).SUVmax of B-cell NHL had positive correlation with Ki-67 expression (r =0.493,P =0.001) and negative correlation with CD138 (r =-0.654,P =0.008).While SUVmax of T-cell NHL had no correlation with Ki-67 expression (P =0.213),but had negative correlation with CD56 (r =-0.545,P =0.044).Conclusions Different subtype of NHL manifests markedly different intensity of FDG uptake,but most lesions of lymphoma are FDG avid.Metabolic activity is lower in indolent B-cell NHL than in aggressive B-cell NHL and T-cell lymphoma,which is concordant with its aggressiveness.SUVmax of B-cell NHL correlates with expression of Ki-67 and CD138.SUVmax of T-cell NHL is associated with the expression of CD56,no correlation is detected between SUV max of T-cell NHL and Ki-67 proliferation.