中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2014年
33期
2597-2601
,共5页
阚芳芳%方福生%田慧%李春霖%刘敏燕%卢艳慧%孙般若%王传海
闞芳芳%方福生%田慧%李春霖%劉敏燕%盧豔慧%孫般若%王傳海
감방방%방복생%전혜%리춘림%류민연%로염혜%손반약%왕전해
老年病%糖尿病,非胰岛素依赖型%死亡
老年病%糖尿病,非胰島素依賴型%死亡
노년병%당뇨병,비이도소의뢰형%사망
Senile diseases%Diabetes mellitus,non-insulin-dependent%Death
目的 观察2型糖尿病对老年人群死亡风险的影响.方法 采用前瞻性队列分析,对一组老年人群随访17年,基线时根据其是否患有糖尿病分为糖尿病组(DM)和非糖尿病组(N-DM),观察两组的生存情况,应用COX风险比例模型分析相关影响因素,Kaplan-Meier法分析累计生存率.结果 共纳入研究对象2 142例,其中糖尿病组746例,非糖尿病组1 396例.随访17年,糖尿病组死亡380例(50.9％),非糖尿病组死亡453例(32.45％,P＜0.01);糖尿病组和非糖尿病组前3位死亡原因均为恶性肿瘤、呼吸系统疾病和心血管疾病.单因素生存曲线分析显示,糖尿病组全因死亡、心血管疾病导致死亡的累计死亡率均显著高于非糖尿病组(P＜0.01).多因素COX风险分析显示,在多因素调整后,2型糖尿病是影响老年人全因死亡、心血管疾病导致死亡的独立危险因素,HR和95％ CI分别为1.36(1.192～1.558,P＜0.01)、3.26(2.887～3.690,P＜0.01).结论 2型糖尿病是老年人群死亡风险增加的重要危险因素.
目的 觀察2型糖尿病對老年人群死亡風險的影響.方法 採用前瞻性隊列分析,對一組老年人群隨訪17年,基線時根據其是否患有糖尿病分為糖尿病組(DM)和非糖尿病組(N-DM),觀察兩組的生存情況,應用COX風險比例模型分析相關影響因素,Kaplan-Meier法分析纍計生存率.結果 共納入研究對象2 142例,其中糖尿病組746例,非糖尿病組1 396例.隨訪17年,糖尿病組死亡380例(50.9％),非糖尿病組死亡453例(32.45％,P＜0.01);糖尿病組和非糖尿病組前3位死亡原因均為噁性腫瘤、呼吸繫統疾病和心血管疾病.單因素生存麯線分析顯示,糖尿病組全因死亡、心血管疾病導緻死亡的纍計死亡率均顯著高于非糖尿病組(P＜0.01).多因素COX風險分析顯示,在多因素調整後,2型糖尿病是影響老年人全因死亡、心血管疾病導緻死亡的獨立危險因素,HR和95％ CI分彆為1.36(1.192～1.558,P＜0.01)、3.26(2.887～3.690,P＜0.01).結論 2型糖尿病是老年人群死亡風險增加的重要危險因素.
목적 관찰2형당뇨병대노년인군사망풍험적영향.방법 채용전첨성대렬분석,대일조노년인군수방17년,기선시근거기시부환유당뇨병분위당뇨병조(DM)화비당뇨병조(N-DM),관찰량조적생존정황,응용COX풍험비례모형분석상관영향인소,Kaplan-Meier법분석루계생존솔.결과 공납입연구대상2 142례,기중당뇨병조746례,비당뇨병조1 396례.수방17년,당뇨병조사망380례(50.9％),비당뇨병조사망453례(32.45％,P＜0.01);당뇨병조화비당뇨병조전3위사망원인균위악성종류、호흡계통질병화심혈관질병.단인소생존곡선분석현시,당뇨병조전인사망、심혈관질병도치사망적루계사망솔균현저고우비당뇨병조(P＜0.01).다인소COX풍험분석현시,재다인소조정후,2형당뇨병시영향노년인전인사망、심혈관질병도치사망적독립위험인소,HR화95％ CI분별위1.36(1.192～1.558,P＜0.01)、3.26(2.887～3.690,P＜0.01).결론 2형당뇨병시노년인군사망풍험증가적중요위험인소.
Objective To explore the mortality risks of elders with and without type 2 diabetes mellitus (T2DM) during a fellow-up period of 17 years.Methods The subjects were elderly patients (＞60years old) undergoing annual health examinations at our hospital.And the incidence and risk factors were analyzed by Kaplan-Meier method and COX's proportional hazard.Results A total of 2 142 subjects were divided into T2DM group (DM,n =746) and non-T2DM group (N-DM,n =1 396).During a 17-year follow-up,the mortality rate of all causes was 50.9％ in DM group versus 32.45％ in N-DM group (P ＜ 0.01).The major mortality causes were malignant tumor,respiratory disease and cardiovascular disease.Kaplan-Meier analysis revealed that the accumulative mortality of all causes and cardiovascular with DM was significantly above that of N-DM.The independent mortality risk factors of elders was T2DM (P ＜ 0.01,HR =1.36,95％ CI:1.192-1.558) and cardiovascular disease (P ＜ 0.01,HR =3.26,95％ CI:2.887-3.690)based upon the COX's proportional hazard analysis.Conclusion Type 2 diabetes mellitus is an independent risk factor for elders with increased mortality risk.
