中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2014年
34期
2641-2644
,共4页
孙美玲%闫迪%姜淑娟%顾宪民%马卫霞
孫美玲%閆迪%薑淑娟%顧憲民%馬衛霞
손미령%염적%강숙연%고헌민%마위하
白细胞介素-27%胸腔积液%结核,胸膜%腺苷脱氨酶%γ干扰素
白細胞介素-27%胸腔積液%結覈,胸膜%腺苷脫氨酶%γ榦擾素
백세포개소-27%흉강적액%결핵,흉막%선감탈안매%γ간우소
Interleukin-27%Pleural effusion%Tuberculosis,pleural%Adenosine deaminase%Interferon-γ
目的 探讨白细胞介素(IL)-27对结核性胸腔积液的诊断价值.方法 对2013年3月至2014年2月山东省立医院呼吸科收治的76例胸腔积液患者按照胸腔积液性质分为:(1)结核组:结核性胸腔积液患者40例,其中男22例,女18例;年龄19～73岁;(2)恶性组:恶性胸腔积液患者36例,其中男20例,女16例;年龄33 ～78岁;包括肺癌28例,淋巴瘤3例,食管癌1例,原发部位不确定的肿瘤4例.采用酶联免疫吸附法检测两组患者胸腔积液和血清中的IL-27浓度并进行统计学分析,应用受试者工作特征(ROC)曲线判断其对结核性胸腔积液的诊断价值.结果 结核组胸腔积液中IL-27的浓度为(1 402±321) ng/L,显著高于恶性组的(556±133) ng/L,且显著高于本组血清中的(499±88) ng/L(均P＜0.05).应用ROC曲线确定IL-27诊断结核性胸腔积液的最佳临界值为838 ng/L,敏感度为95.0％,特异度为97.2％,准确度为96.1％.结论 IL-27对结核性胸腔积液的诊断有重要参考价值,值得临床推广和应用.
目的 探討白細胞介素(IL)-27對結覈性胸腔積液的診斷價值.方法 對2013年3月至2014年2月山東省立醫院呼吸科收治的76例胸腔積液患者按照胸腔積液性質分為:(1)結覈組:結覈性胸腔積液患者40例,其中男22例,女18例;年齡19～73歲;(2)噁性組:噁性胸腔積液患者36例,其中男20例,女16例;年齡33 ～78歲;包括肺癌28例,淋巴瘤3例,食管癌1例,原髮部位不確定的腫瘤4例.採用酶聯免疫吸附法檢測兩組患者胸腔積液和血清中的IL-27濃度併進行統計學分析,應用受試者工作特徵(ROC)麯線判斷其對結覈性胸腔積液的診斷價值.結果 結覈組胸腔積液中IL-27的濃度為(1 402±321) ng/L,顯著高于噁性組的(556±133) ng/L,且顯著高于本組血清中的(499±88) ng/L(均P＜0.05).應用ROC麯線確定IL-27診斷結覈性胸腔積液的最佳臨界值為838 ng/L,敏感度為95.0％,特異度為97.2％,準確度為96.1％.結論 IL-27對結覈性胸腔積液的診斷有重要參攷價值,值得臨床推廣和應用.
목적 탐토백세포개소(IL)-27대결핵성흉강적액적진단개치.방법 대2013년3월지2014년2월산동성립의원호흡과수치적76례흉강적액환자안조흉강적액성질분위:(1)결핵조:결핵성흉강적액환자40례,기중남22례,녀18례;년령19～73세;(2)악성조:악성흉강적액환자36례,기중남20례,녀16례;년령33 ～78세;포괄폐암28례,림파류3례,식관암1례,원발부위불학정적종류4례.채용매련면역흡부법검측량조환자흉강적액화혈청중적IL-27농도병진행통계학분석,응용수시자공작특정(ROC)곡선판단기대결핵성흉강적액적진단개치.결과 결핵조흉강적액중IL-27적농도위(1 402±321) ng/L,현저고우악성조적(556±133) ng/L,차현저고우본조혈청중적(499±88) ng/L(균P＜0.05).응용ROC곡선학정IL-27진단결핵성흉강적액적최가림계치위838 ng/L,민감도위95.0％,특이도위97.2％,준학도위96.1％.결론 IL-27대결핵성흉강적액적진단유중요삼고개치,치득림상추엄화응용.
Objective To explore the diagnostic value of interleukin-27 (IL-27) in tuberculous pleural effusion.Methods A total of 76 patients of pleural effusion treated at Shandong Provincial Hospital from March 2013 to February 2014 in accordance with the natures of effusion fluid were divided into:(1) Tuberculosis group of tuberculous pleural effusion (n =40),including 22 males and 18 females; aged 19 to 73 years; (2) Malignant group of malignant pleural effusion (n =36),including 20 males and 16 females; aged 33 to 78 years old; including lung cancer (n =28),lymphoma (n =3),esophageal (n =1) and uncertain primary tumor site (n =4).The effusion and serum levels of IL-27 were detected by enzymelinked immunosorbent assay (ELISA) and the results analyzed.And the curve of receiver operating characteristic (ROC) was employed to determine the diagnostic value of IL-27 in tuberculous pleural effusion.Results The level of IL-27 was (1 402 ± 321) ng/L in tuberculous pleural effusion and it was significantly higher than those in malignant pleural effusion (556 ± 133) ng/L and sera (499 ± 88) ng/L (both P ＜ 0.05).According to the ROC curve,the cut-off value of IL-27 was 838 ng/L in diagnosing tuberculous pleural effusion.And the rates of diagnostic sensitivity,specificity and accuracy of IL-27 were 95.0％,97.2％ and 96.1％ respectively.Conclusions Detection of pleural effusion IL-27 concentration is of great importance in the diagnosis of tuberculous pleural effusion.And it is worthy of wider clinical promotion.
