CAJ | 학술논문

目的对正常新生儿脐带血凝血因子活性水平进行初步研究.方法临床实验研究.收集2011年11月至2012年1月广州市妇女儿童医疗中心产科正常新生儿脐带血136份(均为广州市常住人口所分娩的新生儿),采用CA-1500全自动凝血分析仪检测脐带血FⅡ、FV、FⅦ、FVⅢ、FⅨ、FⅩ、FⅪ和FⅫ等8种凝血因子的活性水平.结果 FⅡ、FV、FVⅡ、FVⅢ、FⅨ、FⅩ、FⅪ和FⅫ 等8种凝血因子活性水平的95％参考范围(双侧)分别为27.04％～ 49.02％、53.30％～ 116.40％、27.80％～56.70％、19.16％～ 113.06％、19.85％～ 35.65％、24.20％～48.00％、24.40％～42.20％及9.20％～54.60％;99％参考范围(双侧)分别为23.56％～52.50％、53.30％～116.40％、27.80％～56.70％、4.31％～ 127.91％、17.35％～ 38.15％、24.20％～48.00％、24.40％～42.20％及9.20％～54.60％.结论建立了正常新生儿脐带血凝血因子活性水平,可为新生儿先天性或遗传性凝血因子缺乏诊断及鉴别诊断提供实验依据.
목적 대정상신생인제대혈응혈인자활성수평진행초보연구.방법 림상실험연구.수집2011년11월지2012년1월엄주시부녀인동의료중심산과정상신생인제대혈136빈(균위엄주시상주인구소분면적신생인),채용CA-1500전자동응혈분석의검측제대혈FⅡ、FV、FⅦ、FVⅢ、FⅨ、FⅩ、FⅪ화FⅫ등8충응혈인자적활성수평.결과 FⅡ、FV、FVⅡ、FVⅢ、FⅨ、FⅩ、FⅪ화FⅫ 등8충응혈인자활성수평적95％삼고범위(쌍측)분별위27.04％～ 49.02％、53.30％～ 116.40％、27.80％～56.70％、19.16％～ 113.06％、19.85％～ 35.65％、24.20％～48.00％、24.40％～42.20％급9.20％～54.60％;99％삼고범위(쌍측)분별위23.56％～52.50％、53.30％～116.40％、27.80％～56.70％、4.31％～ 127.91％、17.35％～ 38.15％、24.20％～48.00％、24.40％～42.20％급9.20％～54.60％.결론 건립료정상신생인제대혈응혈인자활성수평,가위신생인선천성혹유전성응혈인자결핍진단급감별진단제공실험의거.
Objective To study the levels of coagulation factors in cord blood from normal newborns.Methods The study was clinical experimental study.One hundred and thirty-six cord blood samples collected from newborns who were born in Guangzhou Women and Children's Medical Center from November 2011 to January 2012.The levels of eight coagulation factors FⅡ,FV,FVⅡ,FVⅢ,FⅨ,FⅩ,FⅪ and FⅫ in cord blood were detected using CA-1500 Automatic Blood Coagulation Analyzer.Results The levels of eight coagulation factors in cord blood:the 95％ reference ranges were 27.04％-49.02％,53.30％-116.40％,27.80％-56.70％,19.16％-113.06％,19.85％-35.65％,24.20％-48.00％,24.40％-42.20％ and 9.20％-54.60％ respectively.The 99％ reference ranges were 23.56％-52.50％,53.30％-116.40％,27.80％-56.70％,4.31％-127.91％,17.35％-38.15％,24.20％-48.00％,24.40％-42.20％ and 9.20％-54.60％ respectively.Conclusion The study establishes the reference ranges for levels of coagulation factors in cord blood,it will provide experimental basis for diagnosis and differential diagnosis for neonatal congenital or hereditary coagulation factor deficiency.