CAJ | 학술논문

肝脏纤维化是各种慢性肝病所致的肝脏损伤的共同通路.它的非侵入性评估方法方便易行,便于疾病动态监测,具有临床应用价值.肝纤维化的血清学标志物包括反映细胞外基质生成的直接标志物和体现肝脏合成、代谢、储备功能的间接标志物.各种综合血清学标志物评估模型可确定显著性纤维化和肝硬化,减少不必要的肝脏穿刺活检,可辅助疾病的诊断分期、预后评估、治疗监测.现有的血清学标志物检测平台和试剂的分析性能具有较大的差异,检测的标准化将有助于提高结果的可比性.大规模、多中心的临床验证研究对推广适合中国慢性肝病人群的综合血清标志物评估模型非常必要.
간장섬유화시각충만성간병소치적간장손상적공동통로.타적비침입성평고방법방편역행,편우질병동태감측,구유림상응용개치.간섬유화적혈청학표지물포괄반영세포외기질생성적직접표지물화체현간장합성、대사、저비공능적간접표지물.각충종합혈청학표지물평고모형가학정현저성섬유화화간경화,감소불필요적간장천자활검,가보조질병적진단분기、예후평고、치료감측.현유적혈청학표지물검측평태화시제적분석성능구유교대적차이,검측적표준화장유조우제고결과적가비성.대규모、다중심적림상험증연구대추엄괄합중국만성간병인군적종합혈청표지물평고모형비상필요.
Hepatic fibrosis is the final common pathway for liver injury caused by various chronic liver diseases.Noninvasive assessments of liver fibrosis are valuable in clinical use since they are easy to apply and monitor disease progression.Serologic biomarkers for liver fibrosis consist of direct markers which reflect ECM turnover and indirect markers which show liver function of synthesis,metabolism and reservation.A number of assessment models can identify significant fibrosis and cirrhosis,and avoid unnecessary liver biopsy.They can be used for disease staging,prognosis prediction,and treatment surveillance.Variation of analytical performances exists among diverse analyzers and assays.The standardization of these tests will enhance their comparability.Large scale and multicenter clinical verification studies are needed for the clinical utility of these assessment models based on Chinese population of chronic hepatic diseases.