CAJ | 학술논문

目的探索波长650、810 nm的半导体激光治疗中、重度痤疮的临床疗效及安全性.方法将87例面部痤疮患者,分为激光治疗组(A组)和药物治疗组(B组).A组:用波长650、810 nm半导体激光连续输出功率400～450 mW,非接触性照射(距离为2～3 cm),10 min/次,1次/d,共2周；然后,隔日1次,共2周,16次；B组:口服罗红霉素胶囊0.15g,2次/d,共4周,配合口服维生素B6,外用绿药膏治疗.治疗前及治疗后每周进行临床疗效观察,数码拍照以备对比分析,并在治疗结束后,随访4个月.同时,记录治疗过程中出现的不良反应.结果 A组和B组疗效在治疗后2周(65.0％比42.6％,P＞0.05)、4周(92.5％比76.5％,P＞0.05)差异无统计学意义,但A组复发率显著低于B组,差异有统计学意义(30.0％比61.7％,P＜0.01).结论与药物治疗相比,半导体激光治疗中、重度痤疮可显著降低其复发率.
목적 탐색파장650、810 nm적반도체격광치료중、중도좌창적림상료효급안전성.방법 장87례면부좌창환자,분위격광치료조(A조)화약물치료조(B조).A조:용파장650、810 nm반도체격광련속수출공솔400～450 mW,비접촉성조사(거리위2～3 cm),10 min/차,1차/d,공2주；연후,격일1차,공2주,16차；B조:구복라홍매소효낭0.15g,2차/d,공4주,배합구복유생소B6,외용록약고치료.치료전급치료후매주진행림상료효관찰,수마박조이비대비분석,병재치료결속후,수방4개월.동시,기록치료과정중출현적불량반응.결과 A조화B조료효재치료후2주(65.0％비42.6％,P＞0.05)、4주(92.5％비76.5％,P＞0.05)차이무통계학의의,단A조복발솔현저저우B조,차이유통계학의의(30.0％비61.7％,P＜0.01).결론 여약물치료상비,반도체격광치료중、중도좌창가현저강저기복발솔.
Objective To evaluate the efficacy and safety of 650 nm,810 nm diode laser on the treatment of moderate to severe acne.Methods A total of 87 patients with moderate to severe acne were divided into diode laser group (group A) and medication group (group B).In group A,the patients were irradiated with 650,810 nm diode laser at the fluence of 400-450 mW distance of 2-3 cm.In group B,the patients were treated with roxithromycin combined with vitamin B6 and gel lincomycini.Clinical follow-up was performed every week for 4 months.All the adverse effects were recorded.Results There was no significantly statistical difference in the cure rate between the two groups (group A versus group B at 2 weeks:65.0 ％ versus 42.6 ％,P＞0.05; at 4 weeks:92.5 ％ versus 76.5 ％,P＞0.05).However,the recurrence rate of group A was much lower than that of group B (30.0 ％ versus 61.7 ％,P＜0.01).There were no severe adverse effects in both groups during the period of the follow-up.Conclusions Compared to the medication,650,810 nm diode laser appears to be associated with lower recurrence rate in the treatment of moderate to severe acne.