CAJ | 학술논문

目的通过对A型肉毒毒素肌内注射后不同时间段肌肉的改变进行观察,了解肉毒毒素对肌肉的改变过程,并为化学去神经肌肉游离移植提供理论依据.方法对16只活体兔桡侧腕伸肌进行肉毒毒素注射,分为4组(即1、2、3、4周组),每组4个肌肉,躯体对侧作为对比.分别在注射后1～4周进行大体观察,以及组织学和电镜观察.结果药物注射后1周,肌内酶、糖原和线粒体都开始减少,体积的减少在3周左右明显,4周后肌酶的减少更加明显,并且内部区域有坏死灶,但体积较前有所恢复.结论 A型肉毒毒素肌内注射后可以减缓肌肉代谢和缩小肌肉体积,其中以第3周最为明显,可以为化学去神经肌肉游离移植的时间选择提供参考.
목적 통과대A형육독독소기내주사후불동시간단기육적개변진행관찰,료해육독독소대기육적개변과정,병위화학거신경기육유리이식제공이론의거.방법 대16지활체토뇨측완신기진행육독독소주사,분위4조(즉1、2、3、4주조),매조4개기육,구체대측작위대비.분별재주사후1～4주진행대체관찰,이급조직학화전경관찰.결과 약물주사후1주,기내매、당원화선립체도개시감소,체적적감소재3주좌우명현,4주후기매적감소경가명현,병차내부구역유배사조,단체적교전유소회복.결론 A형육독독소기내주사후가이감완기육대사화축소기육체적,기중이제3주최위명현,가이위화학거신경기육유리이식적시간선택제공삼고.
Objective To study the changes of muscle being injected with botulinum toxin A in different period of time,helping for chemically denervated muscle transplantation.Methods Sixteen rabbits were divided into 4 groups.The extensor carpi radialis muscle in one side was chosen for experimental group with the opposite muscle for control group.Morphological changes,histological changes and electron microscopic changes of muscle being injected with botulinum toxin A were observed from the first week to the fouth week.Results The quantity of glycogen and mitochondria in the muscles reduced in the first week.But it was obvious in the third week.We also found some necrotic areas in the fouth week with the muscles restoring.Conclusions The effect of metabolism slowing down and the volume of muscle reducing after botulinum toxin A injection is obvious in third weeks.It could help us choose the best time of chemically denervated muscle transplantation.